Protein Alignment Eph and si:ch73-383l1.1

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_021331611.1
• Gene: si:ch73-383l1.1 / 101885162
• ZFINID: ZDB-GENE-121214-64
• Length: 1392
• Species: Danio rerio
• Alignment Length: 1078
• Identity: 248/1078 - (23%)
• Similarity: 394/1078 - (36%)
• Gaps: 278/1078 - (25%)

  Fly   151 GSANRL---------YIEIQFTIRDCSLFPGN--ALSCKETFSLLFYEFDAATREPPPWQTDSYR 204
            |:.|:|         |..::....:|.:..||  ..|.:...:|.|.:   :.||     ...|.
Zfish    30 GTDNKLSTLSDLDQQYKTLRKFYENCEVVMGNLEITSIERNRNLSFLK---SIRE-----VTGYV 86

  Fly   205 LIA------------RIAAG----EGRFNQNSDVDINTEVKSIAV---NKKGVYFAFRDQGA--C 248
            |:|            ||..|    |||:             |:|:   .::..||..|..|.  .
Zfish    87 LVALNQFDYLPLENLRIIRGTKLYEGRY-------------SLAIFLNYRRDGYFGLRQLGLRNL 138

  Fly   249 ISVLAVKVYY----ITCPAVTENFAHFNETPTGREITIIEKQN--GTC-----VDNAEPYETPTY 302
            ..:|...||.    ..|.|.|.::....:.|.. |:.::...|  .||     ..|...:.....
Zfish   139 TEILNGGVYVDQNKFLCHADTIHWQDIIKNPRS-ELLVVPSNNSGNTCRRCHRSCNGRCWGPQED 202

  Fly   303 LCKGDGKWTILTGGC--RCKAGYEPNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNASKTGSPFC 365
            .|:...| |:....|  ||...|..|..::   ||..|.| .|:.|.|..|   :|.:.:|:...
Zfish   203 QCQSLTK-TVCAEQCDGRCFGPYVSNCCHR---ECAGGCF-GPKDTDCFAC---TNFNDSGACVT 259

  Fly   366 KCASGFYRHPNDGR--HMP-------CYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETN 421
            :|...|..:|...:  |.|       .:.....|.|..   ||.:|.:   .|...|::...|.|
Zfish   260 QCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFV---VDHSSCV---RACPSNKTEVEENN 318

  Fly   422 SKIYHSDIVYKIKCNICSPNVVYNPSTDTFNETK-ITLTNLEPVTTYTV---------------Q 470
            .|:.       |:|....|.:.....|.:....: :..:|:|.....|.               .
Zfish   319 IKMC-------IQCTEICPKMCDGIGTGSLQSAQTVDSSNIEKFVNCTKINGNLIFLITGIKGDM 376

  Fly   471 IHAINSV--SHINEFKR-------------HSNESSLVAVSDIV-------FSNTSLLNIP---- 509
            .|.|.::  ..:|.|:.             ..|.:.|...|::|       :|..|||.:.
Zfish   377 YHGIRALDPERLNVFRTVREITGYLNIQSWPENMTDLSVFSNLVTIGGRTLYSGISLLILKQRWI 441

  Fly   510 -----LDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLE------------------- 550
                 ..|.|:..|...:...::....|||....:...:.:.|.::
Zfish   442 TSLQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQKAKIKDNRDPRECSQQRMVCDPLC 506

  Fly   551 -----WDKPVQSDFPLEFY---------------EVRWFPK----VELDAINKSALNTKETKAHI 591
                 |..........:::               :||.|..    ||.|:..:.| ..|....|.
Zfish   507 SVSGCWGPGPNQCLSCKYFSRGRTCVRSCNLYNGDVREFANGSTCVECDSQCEKA-EDKSLTCHG 570

  Fly   592 VGLLENTEYGFQVRC-----------KTNNGFGSYSNMIYAQ--------------TLQSVGSVY 631
            .|      ....|:|           |..:|....::.|:..              |....|...
Zfish   571 PG------PDHCVKCLHLKDGPNCVEKCPDGLQGANSFIFKYPETNNECHPCHPNCTQGCTGPRI 629

  Fly   632 DDSVQI----RFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSM 692
            .|.:.|    ..||..::.|:..:||..:....|.|.|   .:.||..
Zfish   630 QDCIGILDRTPLIAAGVIGGMFVVVIVALGFAIFFRRK---SIKKKRA----------------- 674

  Fly   693 DTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCR 757
                :.:.|...:..||..:..:         ||||.....:|.:...:   .|:|.|.||.|.:
Zfish   675 ----LRRFLETELVEPLTPSGTA---------PNQAQLRILKETELKRV---KILGTGAFGTVYK 723

  Fly   758 GRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITE 822
            | :.:|......|.||||.|...:..||..:|:.||.||...:||:::.|.||.. |..:.::|:
Zfish   724 G-IWVPEGETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCL-SPTIQLVTQ 786

  Fly   823 YMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADF 887
            .|.:|.|..::..:.....:..|:.....||.||.||.:...||||||||||||.:....||.||
Zfish   787 LMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDF 851

  Fly   888 GLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQ 952
            ||:|.:|.....|:...||:|::|.|.|.|.:||||..||||||||.:||:|::|.:||.....:
Zfish   852 GLARLLETNEKEYSADEGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTR 916

  Fly   953 DVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTR---- 1013
            ::...:|||.|||.|..|...:|.:|:.||......||.|..:.:....:||.||..|..:
Zfish   917 EIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDR 981

  Fly  1014 ---PSPESDGNH------ILDGQRGQNIFISTDLWLEH 1042
               |||    ||      :||.:...::..:.:..:.|
Zfish   982 MKLPSP----NHSKFFQSLLDEEELDDLMDADEYLVPH 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	30/144 (21%)
		FN3	387..476	CDD:238020	19/104 (18%)
		FN3	536..623	CDD:238020	17/154 (11%)
		EphA2_TM	640..738	CDD:464211	18/97 (19%)
		PTKc_EphR	736..1002	CDD:270629	99/265 (37%)
		SAM_1	1029..1092	CDD:425739	1/14 (7%)
si:ch73-383l1.1	XP_021331611.1	Recep_L_domain	54..166	CDD:460032	29/132 (22%)
		Furin-like	183..331	CDD:395614	38/168 (23%)
		Recep_L_domain	357..477	CDD:460032	19/119 (16%)
		GF_recep_IV	501..633	CDD:464344	19/138 (14%)
		TM_ErbB4	631..674	CDD:213053	12/45 (27%)
		Protein Kinases, catalytic domain	699..995	CDD:473864	110/304 (36%)