Protein Alignment Eph and epha6

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_031752444.1
• Gene: epha6 / 100495504
• XenbaseID: XB-GENE-6032564
• Length: 1008
• Species: Xenopus tropicalis
• Alignment Length: 1087
• Identity: 427/1087 - (39%)
• Similarity: 597/1087 - (54%)
• Gaps: 154/1087 - (14%)

  Fly    61 RMSLLRTILLIIISIHFKLA--HA--DQVVLLDTTRE-ATLEWTRYPYGPQAQTPGWVEESFT-- 118
            |..|.:|:||:.|...|::.  |.  :||||||||.. ..|.|..||..      ||  ::.|
 Frog     7 RTVLEKTVLLLSIVGSFRVGSNHLSDNQVVLLDTTTAIGELGWKTYPVN------GW--DAITEM 63

  Fly   119 -DFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFS 182
             ::.:.|:  :|.||:|...|.||||.:.:|.|.:|.::::|::||:|||:..|....:|||||:
 Frog    64 DEYNRPIH--TYQVCNVMEANQNNWLRTNWISRDAAQKVFVEMKFTLRDCNSIPWVVGTCKETFN 126

  Fly   183 LLFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFAF 242
            |.:.|.|.|  ....::...|..|..|||.|. |.|    :..:.:||||:.:. :.|||.|.||
 Frog   127 LHYMESDDA--HAVKFKPTQYSKIDTIAADES-FTQMDLGDRILKLNTEVREVGPITKKGFYLAF 188

  Fly   243 RDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGD 307
            :|.||||::::|:|||..||.:..|.|.|.:|....:.:.:.:..|:|:..||..:||...|..|
 Frog   189 QDIGACIALVSVRVYYKKCPYMVRNLAMFPDTIPRVDSSSLVEVRGSCIKYAEERDTPKLYCGAD 253

  Fly   308 GKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKS-PEVTKCTPCPPNSNASKTGSPFCKCASGF 371
            |.|.:..|.|.|..|||.  .:.:|..|..|.:|| ....||:.|||:|......:..|:|..||
 Frog   254 GDWLVPLGRCVCSIGYEE--VDGSCHACRPGFYKSFAGNIKCSKCPPHSFTYAEATTVCQCEKGF 316

  Fly   372 YRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCN 436
            ||...|...|.|..||:||.|.. ..:::|:..:.||.|.       :|..:   .|:||.:.|.
 Frog   317 YRAEKDPPSMACTKPPSAPRNAN-FNMNETALYLEWSPPI-------DTGGR---KDVVYNVLCK 370

  Fly   437 ICSPN--------VVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLV 493
            .|.|:        :.|.|:........:|:.:......||..|.|.|.||.:
 Frog   371 KCDPSQCELCGGGIRYVPAHSGLQNASVTVLDFLSHVNYTFDIEATNGVSEL------------- 422

  Fly   494 AVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSD 558
                      |.|..|         ...|:.||:....|.:..:|....:.....|.|.:|   |
 Frog   423 ----------SFLPKP---------YTSIMITTDQEAPSLIGMVRKDWASQNSIALSWQEP---D 465

  Fly   559 FP---LEFYEVRW----FPKV-----------ELDAINKSALNTKETKAHIVGLLENTEYGFQVR 605
            :|   :..||:::    :|::           |.:.::.|:..:|.....|.||...|:|.|.:|
 Frog   466 YPKGLIVDYEIKYYEKDYPRIAPAFWHYLRVEEHEQLSYSSTRSKAPSVIITGLKPATKYIFHIR 530

  Fly   606 CKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVI---FIIAT---VYFMRS 664
            .:|..|:.:||:....:|......:..:..||..||.|.|.|...|||   |.:.|   .:::::
 Frog   531 VRTTAGYSAYSHKFEFETGDETSDLAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKA 595

  Fly   665 KHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAI 729
            |.:.: :|:..|                     ::..||.     |...::|:||.|||||:.|:
 Frog   596 KMKSE-EKRRAN---------------------LQNGHLQ-----FPGVKTYIDPDTYEDPSLAV 633

  Fly   730 REFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEAS 794
            .|||:|||.:.|.||.:||.||||:||.||||.|..  ::|.|||||||.|..::.|.|||.|||
 Frog   634 HEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPAK--KEIPVAIKTLKGGYVDRQRKDFLREAS 696

  Fly   795 IMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYL 859
            |||||||||:|.|:||||:|.||||:.|||||||||:|||.:||:|..:||:.|||||||||.||
 Frog   697 IMGQFDHPNIIRLEGVVTKSRPVMIVVEYMENGSLDSFLRKHDGQFTVIQLVGMLRGIASGMKYL 761

  Fly   860 SDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEAIAFRKFT 923
            |||.||||||||||:|||:.|:||::||||||.:|:..| ||||.|||||:|||||||||||||:
 Frog   762 SDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRKFS 826

  Fly   924 SASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTH 988
            ||||.||||:|:||||||||||||..||||||.|||:||||||||.||.:|:||||.||||.|..
 Frog   827 SASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPVSLHQLMLHCWQKDRNI 891

  Fly   989 RPTFASIVSTLDNLARQPQSLLTTRPS----PESDGN----HILDGQRGQNIFISTDLWLEHIKM 1045
            ||.|:.||..||.|.|.|.:|......    |||.|:    |.:         ::...|||.|||
 Frog   892 RPKFSDIVGFLDKLIRNPSALHILVEDILGMPESPGDAPEYHFV---------VTVSEWLESIKM 947

  Fly  1046 SRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092
            .:|.|:|..:.......:||:|...:..:||||:|||::|:...:.|
 Frog   948 GQYAHNFMASGFTTLDMVSRMTIDDIRRIGITLIGHQRRIVTSIQTL 994

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	70/183 (38%)
		FN3	387..476	CDD:238020	22/96 (23%)
		FN3	536..623	CDD:238020	23/104 (22%)
		EphA2_TM	640..738	CDD:464211	30/103 (29%)
		PTKc_EphR	736..1002	CDD:270629	188/266 (71%)
		SAM_1	1029..1092	CDD:425739	20/62 (32%)
epha6	XP_031752444.1	EphR_LBD_A6	34..206	CDD:198452	71/184 (39%)
		FN3	333..421	CDD:473895	23/98 (23%)
		FN3	441..548	CDD:238020	24/109 (22%)
		EphA2_TM	565..642	CDD:464211	30/103 (29%)
		PTKc_EphR_A	640..906	CDD:270651	188/267 (70%)
		SAM_EPH-A6	933..996	CDD:188946	22/71 (31%)