DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eph and epha6

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:XP_031752444.1 Gene:epha6 / 100495504 XenbaseID:XB-GENE-6032564 Length:1008 Species:Xenopus tropicalis


Alignment Length:1087 Identity:427/1087 - (39%)
Similarity:597/1087 - (54%) Gaps:154/1087 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 RMSLLRTILLIIISIHFKLA--HA--DQVVLLDTTRE-ATLEWTRYPYGPQAQTPGWVEESFT-- 118
            |..|.:|:||:.|...|::.  |.  :||||||||.. ..|.|..||..      ||  ::.|  
 Frog     7 RTVLEKTVLLLSIVGSFRVGSNHLSDNQVVLLDTTTAIGELGWKTYPVN------GW--DAITEM 63

  Fly   119 -DFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFS 182
             ::.:.|:  :|.||:|...|.||||.:.:|.|.:|.::::|::||:|||:..|....:|||||:
 Frog    64 DEYNRPIH--TYQVCNVMEANQNNWLRTNWISRDAAQKVFVEMKFTLRDCNSIPWVVGTCKETFN 126

  Fly   183 LLFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFAF 242
            |.:.|.|.|  ....::...|..|..|||.|. |.|    :..:.:||||:.:. :.|||.|.||
 Frog   127 LHYMESDDA--HAVKFKPTQYSKIDTIAADES-FTQMDLGDRILKLNTEVREVGPITKKGFYLAF 188

  Fly   243 RDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGD 307
            :|.||||::::|:|||..||.:..|.|.|.:|....:.:.:.:..|:|:..||..:||...|..|
 Frog   189 QDIGACIALVSVRVYYKKCPYMVRNLAMFPDTIPRVDSSSLVEVRGSCIKYAEERDTPKLYCGAD 253

  Fly   308 GKWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKS-PEVTKCTPCPPNSNASKTGSPFCKCASGF 371
            |.|.:..|.|.|..|||.  .:.:|..|..|.:|| ....||:.|||:|......:..|:|..||
 Frog   254 GDWLVPLGRCVCSIGYEE--VDGSCHACRPGFYKSFAGNIKCSKCPPHSFTYAEATTVCQCEKGF 316

  Fly   372 YRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCN 436
            ||...|...|.|..||:||.|.. ..:::|:..:.||.|.       :|..:   .|:||.:.|.
 Frog   317 YRAEKDPPSMACTKPPSAPRNAN-FNMNETALYLEWSPPI-------DTGGR---KDVVYNVLCK 370

  Fly   437 ICSPN--------VVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLV 493
            .|.|:        :.|.|:........:|:.:......||..|.|.|.||.:             
 Frog   371 KCDPSQCELCGGGIRYVPAHSGLQNASVTVLDFLSHVNYTFDIEATNGVSEL------------- 422

  Fly   494 AVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSD 558
                      |.|..|         ...|:.||:....|.:..:|....:.....|.|.:|   |
 Frog   423 ----------SFLPKP---------YTSIMITTDQEAPSLIGMVRKDWASQNSIALSWQEP---D 465

  Fly   559 FP---LEFYEVRW----FPKV-----------ELDAINKSALNTKETKAHIVGLLENTEYGFQVR 605
            :|   :..||:::    :|::           |.:.::.|:..:|.....|.||...|:|.|.:|
 Frog   466 YPKGLIVDYEIKYYEKDYPRIAPAFWHYLRVEEHEQLSYSSTRSKAPSVIITGLKPATKYIFHIR 530

  Fly   606 CKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVI---FIIAT---VYFMRS 664
            .:|..|:.:||:....:|......:..:..||..||.|.|.|...|||   |.:.|   .:::::
 Frog   531 VRTTAGYSAYSHKFEFETGDETSDLAAEQGQILVIATAAVGGFTLLVILTLFFLITGRCQWYIKA 595

  Fly   665 KHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAI 729
            |.:.: :|:..|                     ::..||.     |...::|:||.|||||:.|:
 Frog   596 KMKSE-EKRRAN---------------------LQNGHLQ-----FPGVKTYIDPDTYEDPSLAV 633

  Fly   730 REFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEAS 794
            .|||:|||.:.|.||.:||.||||:||.||||.|..  ::|.|||||||.|..::.|.|||.|||
 Frog   634 HEFAKEIDPSRIRIERVIGAGEFGEVCSGRLKTPAK--KEIPVAIKTLKGGYVDRQRKDFLREAS 696

  Fly   795 IMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYL 859
            |||||||||:|.|:||||:|.||||:.|||||||||:|||.:||:|..:||:.|||||||||.||
 Frog   697 IMGQFDHPNIIRLEGVVTKSRPVMIVVEYMENGSLDSFLRKHDGQFTVIQLVGMLRGIASGMKYL 761

  Fly   860 SDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEAIAFRKFT 923
            |||.||||||||||:|||:.|:||::||||||.:|:..| ||||.|||||:|||||||||||||:
 Frog   762 SDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRKFS 826

  Fly   924 SASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTH 988
            ||||.||||:|:||||||||||||..||||||.|||:||||||||.||.:|:||||.||||.|..
 Frog   827 SASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSIEEGYRLPAPMGCPVSLHQLMLHCWQKDRNI 891

  Fly   989 RPTFASIVSTLDNLARQPQSLLTTRPS----PESDGN----HILDGQRGQNIFISTDLWLEHIKM 1045
            ||.|:.||..||.|.|.|.:|......    |||.|:    |.:         ::...|||.|||
 Frog   892 RPKFSDIVGFLDKLIRNPSALHILVEDILGMPESPGDAPEYHFV---------VTVSEWLESIKM 947

  Fly  1046 SRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092
            .:|.|:|..:.......:||:|...:..:||||:|||::|:...:.|
 Frog   948 GQYAHNFMASGFTTLDMVSRMTIDDIRRIGITLIGHQRRIVTSIQTL 994

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 70/183 (38%)
FN3 387..476 CDD:238020 22/96 (23%)
FN3 536..623 CDD:238020 23/104 (22%)
EphA2_TM 644..736 CDD:291255 25/97 (26%)
PTKc_EphR 736..1002 CDD:270629 188/266 (71%)
Pkinase_Tyr 741..999 CDD:285015 184/258 (71%)
SAM_1 1033..1092 CDD:278937 20/58 (34%)
SAM 1039..1092 CDD:197735 20/52 (38%)
epha6XP_031752444.1 EphR_LBD_A6 34..206 CDD:198452 71/184 (39%)
FN3 333..421 CDD:419708 23/98 (23%)
FN3 441..548 CDD:238020 24/109 (22%)
EphA2_TM 564..642 CDD:405290 30/104 (29%)
PTKc_EphR_A 640..906 CDD:270651 188/267 (70%)
SAM_EPH-A6 933..996 CDD:188946 22/71 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 124 1.000 Domainoid score I5425
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 763 1.000 Inparanoid score I545
OMA 1 1.010 - - QHG45908
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm49458
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1010.080

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