Protein Alignment Eph and epha3

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_002931819.2
• Gene: epha3 / 100495045
• XenbaseID: XB-GENE-6035245
• Length: 984
• Species: Xenopus tropicalis
• Alignment Length: 1075
• Identity: 430/1075 - (40%)
• Similarity: 607/1075 - (56%)
• Gaps: 148/1075 - (13%)

  Fly    64 LLRTILLIIISIHFK---LAH-ADQVVLLDTTR-EATLEWTRYPYGPQAQTPGW-----VEESFT 118
            |...:||..||:...   ::| |::|.|||:.. :..|.|..||      :.||     |:|::|
 Frog     5 LCSILLLCSISLSCSGELISHPANEVNLLDSKAIQGELGWISYP------SHGWEEISGVDENYT 63

  Fly   119 DFVKGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSL 183
            ..      |:|.||:|..||.||||.:.:|.|.:|.::|||::||:|||:..|....:|||||:|
 Frog    64 PI------RTYQVCNVMDHNQNNWLRTNWIPRNAAQKIYIELKFTLRDCNSIPLVLGTCKETFNL 122

  Fly   184 LFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFAFR 243
            .:.|.|  ..:...::...:..|..|||.|. |.|    :..:.:||||:.:. ::.||:|.||:
 Frog   123 YYMESD--EDQGVKFREHQFTKIDTIAADES-FTQMDLGDRILKLNTEVREVGPISMKGLYLAFQ 184

  Fly   244 DQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDG 308
            |.|||:::::|:||:..||...:|.|.|.:|......:::|.: |:||::::..:.|...|..:|
 Frog   185 DVGACVALVSVRVYFKKCPFTVKNLAMFTDTVPMDSHSLVEVR-GSCVNHSKEEDPPKMYCSTEG 248

  Fly   309 KWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKS-PEVTKCTPCPPNSNASKTGSPFCKCASGFY 372
            :|.:..|.|.|.||||..  ..||..|..|.:|: ....|||.|||:|:..:.|:.:|.|...||
 Frog   249 EWLVPIGKCLCNAGYEER--GFTCQACRPGFYKAFTGNLKCTKCPPHSSTQEDGATYCNCEKNFY 311

  Fly   373 RHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCNI 437
            |...|...|.|..||:||.|| :..:::||.|:.||.|.       :|..:   .||.:.:.|..
 Frog   312 RADKDPPSMACTRPPSAPRNL-ISNINETSVILDWSWPL-------DTGGR---KDITFNVVCKR 365

  Fly   438 CSPNVVY----------NPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSL 492
            |..||.|          .|.......|.:|:|:|...|.||.:|.::|
 Frog   366 CGVNVKYCEYCKGNLKFIPRQSGLANTTVTVTDLLAHTNYTFEIESVN----------------- 413

  Fly   493 VAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQS 557
             .|||...||    .||          |.:..||.....|.|..:|....:.....|.|.:|...
 Frog   414 -GVSDQSVSN----RIP----------AAVSITTNQAAPSPVTIIRKERTSRNSISLSWQEPEHP 463

  Fly   558 DFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQ 622
            :..:..|||:::.|.|.:. :.:.|..:.|...|..|..:|.|.||:|.:|..|:||.|.....:
 Frog   464 NGIILDYEVKYYEKQEQET-SYTILRARTTNVTINSLKPDTTYIFQIRARTAAGYGSNSRKFEFE 527

  Fly   623 TLQSVGSVYDDSVQIRF--IAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKK----STNHLPLP 681
            |.....|:..::.|:..  |:.|||..:|.:|::|:...:...:|.....|:|    ...||.||
 Frog   528 TSPDSFSISSENSQVVMIGISAAIVIILLTVVVYILIGRFCGYNKSMPGSDEKRLHFGNGHLKLP 592

  Fly   682 LDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAI 746
                                          ..|:|:||||||||:||:.|||:|:|:..|:|:.:
 Frog   593 ------------------------------GIRTYIDPHTYEDPSQAVHEFAKELDSACISIDTV 627

  Fly   747 IGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVV 811
            ||.||||:||.||||:|..  ::|.|||||||.|.:||.|.|||:||||||||:|||:|.|:|||
 Frog   628 IGAGEFGEVCSGRLKLPSK--KEISVAIKTLKAGYTEKQRRDFLSEASIMGQFEHPNIIRLEGVV 690

  Fly   812 TRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLV 876
            |:|.||||:||||||||||:|||.||.:|..:||:.||||||:||.|||||.||||||||||:|:
 Frog   691 TKSKPVMIVTEYMENGSLDSFLRKNDAQFTVIQLVGMLRGIAAGMKYLSDMGYVHRDLAARNILI 755

  Fly   877 NAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMS 940
            |:.|:||::||||||.:|:..: ||||||||||:||||||||::||||||||.||||:|||||||
 Frog   756 NSNLVCKVSDFGLSRILEDDPEAAYTTRGGKIPIRWTAPEAISYRKFTSASDAWSYGIVLWEVMS 820

  Fly   941 YGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQ 1005
            |||||||..|||||||::|:|||||.|||||.||||||||||||.|.:||.|..|||.||.|.|.
 Frog   821 YGERPYWEMSNQDVIKAVEEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFDEIVSILDKLIRN 885

  Fly  1006 PQSL-----LTTRPSPESDGNHILDGQRGQN-----IFISTDLWLEHIKMSRYCHHFKEANLINA 1060
            |.||     .:.|||     |.:||    ||     .|..|..|::.::... ||........::
 Frog   886 PSSLKVIANASIRPS-----NLLLD----QNCADFPAFQPTGDWVDTLQTGP-CHDILTGVAYSS 940

  Fly  1061 -QQISRLTAQQLSDMGITLVGHQKKILHQARQLDT 1094
             :.|::::...:..:|:|:.|.:||.|...|..:|
 Frog   941 CETIAKISLDDMKTVGVTITGPRKKTLSSFRPPET 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	67/185 (36%)
		FN3	387..476	CDD:238020	28/98 (29%)
		FN3	536..623	CDD:238020	23/86 (27%)
		EphA2_TM	640..738	CDD:464211	30/101 (30%)
		PTKc_EphR	736..1002	CDD:270629	189/266 (71%)
		SAM_1	1029..1092	CDD:425739	15/68 (22%)
epha3	XP_002931819.2	EphR_LBD_A3	29..201	CDD:198449	67/186 (36%)
		FN3	<323..>519	CDD:442628	62/239 (26%)
		FN3	437..528	CDD:238020	25/91 (27%)
		EphA2_TM	543..618	CDD:464211	30/104 (29%)
		PTKc_EphR_A	617..883	CDD:270651	189/267 (71%)
		SAM_superfamily	913..975	CDD:472832	13/62 (21%)