DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and LOC100488704

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_031762192.1	Gene:	LOC100488704 / 100488704	-ID:	-	Length:	978	Species:	Xenopus tropicalis

Alignment Length:	1042	Identity:	380/1042 - (36%)
Similarity:	555/1042 - (53%)	Gaps:	146/1042 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LLDTTREAT-LEWTRYPYGPQAQTPGWVEESFTDFVKGINWRSYVVCD--VAYHNVNNWLWSPFI 148
            |||||:|.: :.||.||.|      ||.|.|..|..:.: .|:|.||:  ....|.:|||.:.:|
Frog    23 LLDTTQETSEIGWTSYPQG------GWDEVSVLDGQRRL-LRTYEVCNPYAQQPNQSNWLRTGYI 80

  Fly   149 DRGSANRLYIEIQFTIRDC-SLFP---GNALSCKETFSLLFYEFDAATREPPPWQTDSYRLIARI 209
            :...|.|:|::::|::||| :|.|   .|.|.|:|||: .:|.......|...|:....:.:...
Frog    81 ESRGARRVYVKLRFSVRDCATLKPPPKRNHLVCRETFT-FYYRQAGGPTEADKWEWAEEKWVKVD 144

  Fly   210 AAGEGR-FNQNSDVDINTEVKSI----------AVNKKGVYFAFRDQGACISVLAVKVYYITCPA 263
            ..|.|: |.:    |:...|:..          .:|:||.|.||.|.|||:|:..||||:..||.
Frog   145 TIGPGKSFTR----DLGKGVQGPHMDERILDFGPINRKGFYLAFVDSGACLSLAGVKVYFYKCPF 205

  Fly   264 VTENFAHFNETP-TGREITIIEKQNGTCVDNAEPYETP--TYLCKGDGKWTILTGGCRCKAGYEP 325
            ..:..|.|.||| :|.....:.:..||||..|:|..|.  :..|.|:|:|.:.:|.|.|..|...
Frog   206 TVKGLASFLETPSSGEGGASLSEAIGTCVSGAQPIGTARLSLHCGGEGEWMVSSGSCVCDPGRAE 270

  Fly   326 NYTNKTCTECPLGTFKSPE--VTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPA 388
            :.....|..||.||::.|:  :::|.|||.|||...:|:..|.|..|:||.|.:....||..||:
Frog   271 SEDGTKCPACPPGTYRPPDSPISRCLPCPSNSNTITSGALGCVCDKGYYRTPEENPQSPCTGPPS 335

  Fly   389 APTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI--------KCNICSPNVVYN 445
            ||.:|........:...||.||       .:...:   .:::|.:        :|..|...|.:.
Frog   336 APWDLNYEVTGPGAVSASWRAP-------KDLGGR---PEVLYSVACKECMGGRCLRCGEGVTFR 390

  Fly   446 PSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHIN-EFKRHSNESSLVAVSDIVFSNTSLLNIP 509
            ||......|::.|:.|.|...||:::.|:|.||.:: |..:||:                 ||:.
Frog   391 PSQVGLIHTRVHLSGLLPGVPYTLEVQAVNQVSELSPEQPKHSS-----------------LNLS 438

  Fly   510 LDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVEL 574
            :               ::|| .|.|..:..|..:.:...|.|.:|.|.:..:..|::.:..|.
Frog   439 I---------------SQSV-PSAVPIMHQLHRSKQSITLTWPEPEQPNGKILDYQLCYREKG-- 485

  Fly   575 DAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSV-QIR 638
            |......|.::...|.|.||.....|.||||.::..|:|::|..:|.|||.......:..| ::.
Frog   486 DEGESLYLISETNTATIGGLNPGAIYSFQVRGRSEGGYGAFSGSMYFQTLLGGSEQAEHQVDKLP 550

  Fly   639 FIAGAIVTGVLFLVIFIIA-TVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLH 702
            .|.|:.:..:.|:.|.:|. .:...:||.::                          ||...:|.
Frog   551 LIVGSCLGALAFIGISVILFLILLYKSKRRE--------------------------TPYTDRLQ 589

  Fly   703 LNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFV 767
            ..:|:...| .:.|:||.|||||.:|:.|||||||..::.||.:||.|:||:||||||.:|..
Frog   590 HYITSRGLG-VKYYIDPSTYEDPAEAVHEFAREIDVTFVKIEEVIGSGDFGEVCRGRLCLPSK-- 651

  Fly   768 QDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTF 832
            :::.|.|:||:.||.||.|.:||:||.||||||||||::|:|.||||.|:||:||:||||:||.|
Frog   652 REVAVCIRTLRTGSGEKERAEFLSEAGIMGQFDHPNVVHLEGAVTRSRPIMILTEHMENGALDAF 716

  Fly   833 LRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENAS 897
            ||..:|.|.|||::.||||:|:||.||||.:|.||:|.|.|||||.||:||::  || |..|
Frog   717 LRQCEGGFSTLQMVSMLRGVAAGMRYLSDRSYNHRNLTAHNVLVNGQLVCKVS--GL-RPPE--- 775

  Fly   898 DAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGY 962
                 :|.:..:||.|||.:...||:|||||||||:|:|||.||||||||:.|||:|::::|:.|
Frog   776 -----QGARQSLRWAAPEVLQLHKFSSASDVWSYGIVMWEVTSYGERPYWDMSNQEVLEALEQDY 835

  Fly   963 RLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQ 1027
            |||.|.|||.||:.|||||||::|..||.|..|||:||.:.|.|..|.:...|.......:|..
Frog   836 RLPPPPDCPSALHLLMLDCWQRERAQRPRFEQIVSSLDRMIRNPNCLKSVGVSSSRPSQPLLSN- 899

  Fly  1028 RGQNIFISTDL--------WLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVGHQKK 1084
                  ...||        |||.|||.||..:|.:|.....:.||||||:.:..:|:||.|||||
Frog   900 ------CPPDLPSLSSPHEWLEAIKMQRYKENFDQAGYTTLEAISRLTAEDIRIIGVTLSGHQKK 958

  Fly  1085 IL 1086
            ||
Frog   959 IL 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	63/190 (33%)
		FN3	387..476	CDD:238020	21/96 (22%)
		FN3	536..623	CDD:238020	22/86 (26%)
		EphA2_TM	644..736	CDD:291255	23/92 (25%)
		PTKc_EphR	736..1002	CDD:270629	153/265 (58%)
		Pkinase_Tyr	741..999	CDD:285015	149/257 (58%)
		SAM_1	1033..1092	CDD:278937	28/62 (45%)
		SAM	1039..1092	CDD:197735	26/48 (54%)
LOC100488704	XP_031762192.1	EphR_LBD_B6	20..202	CDD:198443	63/190 (33%)
		TNFRSF	258..>331	CDD:419870	25/72 (35%)
		FN3	334..428	CDD:238020	24/103 (23%)
		fn3	445..527	CDD:394996	22/83 (27%)
		EphA2_TM	552..624	CDD:405290	27/98 (28%)
		PKc_like	622..876	CDD:419665	153/266 (58%)
		SAM_superfamily	902..970	CDD:417767	28/59 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5425
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	763	1.000	Inparanoid score	I545
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	1	1.000	-	-		otm49458
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060