Protein Alignment Eph and epha5

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_012810832.1
• Gene: epha5 / 100488002
• XenbaseID: XB-GENE-988387
• Length: 1030
• Species: Xenopus tropicalis
• Alignment Length: 1052
• Identity: 426/1052 - (40%)
• Similarity: 602/1052 - (57%)
• Gaps: 137/1052 - (13%)

  Fly    83 DQVVLLDT-TREATLEWTRYPYGPQAQTPGW-----VEESFTDFVKGINWRSYVVCDVAYHNVNN 141
            ::|.|||: :....|.|..:|..      ||     |:|::...      .:|.||.|...:.||
 Frog    63 NEVNLLDSRSVMGDLGWIAFPKN------GWEEIGEVDENYAPI------HTYQVCKVMEQSQNN 115

  Fly   142 WLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFDAATREPPPWQTDSYRLI 206
            ||.:.:|....|:|::||::||:|||:..||...:|||||::  |.|::...:....:.:.|..|
 Frog   116 WLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNV--YYFESNEEDGRKIRENQYIKI 178

  Fly   207 ARIAAGEGRFNQ----NSDVDINTEVKSIA-VNKKGVYFAFRDQGACISVLAVKVYYITCPAVTE 266
            ..|||.|. |.:    :..:.:|||::.:. :.|||.|.||:|.||||::::|:|||..||:|..
 Frog   179 DTIAADES-FTELDLGDRIMKLNTEIRDVGPLTKKGFYLAFQDLGACIALVSVRVYYKKCPSVVR 242

  Fly   267 NFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKT 331
            |.|.|.:|.||.:.:.:.:.:|.||:|:...|.|...|..:|:|.:..|.|.|:.|||..  |.|
 Frog   243 NLAVFPDTITGADSSQLLEVSGLCVNNSVKEEAPKMHCSAEGEWLVPIGKCMCEEGYEEK--NNT 305

  Fly   332 CTECPLGTFK-SPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPTNLTL 395
            |..||:|.|| ||:...|:.|||:|..::.||.||.|...:||..:|...|.|..||:||.| .:
 Frog   306 CQACPMGFFKSSPQSLMCSKCPPHSYTNEEGSTFCVCEDRYYRRESDPYTMSCTRPPSAPRN-AI 369

  Fly   396 LFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI---KCNI-------CSPNVVYNPSTDT 450
            ..:::||..:.|       .|.|:|..:   .|:.|.|   |||.       |..:|.|.|....
 Frog   370 SNINETSVFLEW-------MFPSDTGGR---KDVFYNIVCKKCNSLSSPCEECGMHVRYIPQQTG 424

  Fly   451 FNETKITLTNLEPVTTYTVQIHAINSVSHINE-FKRHSNESSLVAVSDIVFSNTSLLNIPLDLNE 514
            ...|.:.:.:|:..|.||.:|.|.|.||.::. |:::            ||.|.
 Frog   425 LKNTSVMVIDLQAHTNYTFEIEAENGVSELSPGFRQY------------VFVNV----------- 466

  Fly   515 VKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDFPLEFYEVRWFPKVELDAINK 579
                      ||.....||:..::...|......|.|.:|.:.:..:..||:::|.|.:..:.
 Frog   467 ----------TTNQAAPSTISIVKKGKIAKSSISLSWQEPDRPNGIILEYEIKYFEKDQESSY-- 519

  Fly   580 SALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQIRFIAGAI 644
            :.:.:|||:..:.||...:.|.||:|.:|..|:|::|.....:|.....:...|..||..||.::
 Frog   520 TIVKSKETEITVEGLKPASSYIFQIRARTAAGYGAFSRRFEFETSPVSFAATGDQSQIPIIAVSV 584

  Fly   645 VTGVLFL---VIFII----ATVYFMRSKH-------QDDLDKK---STNHLPLPLDYASNEVNSM 692
            ..|::.|   |.|::    :...|..|:.       ||..::|   ...|:.||
 Frog   585 TVGIILLAGIVGFLLSGSCSQASFPPSRRCGYSKAKQDPEEEKMHFHNGHIKLP----------- 638

  Fly   693 DTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCR 757
                               ..::|:|||||||||||:.|||:||||:.||||.:||.||||:||.
 Frog   639 -------------------GIKTYIDPHTYEDPNQAVHEFAKEIDASCITIERVIGAGEFGEVCS 684

  Fly   758 GRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITE 822
            ||:|:...  ::..:||||||.|.|:|.|.|||.||||||||||||:|:|:||||:|.||||:||
 Frog   685 GRIKLAGK--RESPIAIKTLKVGYSDKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTE 747

  Fly   823 YMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADF 887
            |||||||||||:.|||.|..:||:.|||||||||.|||||.|||||||.||:|:|:.|:||::||
 Frog   748 YMENGSLDTFLKKNDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAGRNILINSNLVCKVSDF 812

  Fly   888 GLSREIENASD-AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSN 951
            ||||.:|:..: ||||||||||:|||||||||||||||||||||||:|:|||:||||||||..:|
 Frog   813 GLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVISYGERPYWEMTN 877

  Fly   952 QDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTRPSP 1016
            |||||::|:|||||:|||||.||||||||||.|.|..||.|..|||.||.|.|.|.||.|...:.
 Frog   878 QDVIKAVEEGYRLPSPMDCPAALYQLMLDCWHKDRNSRPKFEEIVSILDKLIRNPNSLKTLVNAS 942

  Fly  1017 ESDGNHILD-GQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQISRLTAQQLSDMGITLVG 1080
            ....|.::: ...|...:.|.:.|||.|||.||...|.|....:...::::|.:.|...|:||.|
 Frog   943 NRVSNLLIEHSPGGTGAYRSVNEWLEAIKMGRYTETFMENGFNSMDAVTQVTVEDLRRFGVTLTG 1007

  Fly  1081 HQKKILHQARQL 1092
            |||||::..:::
 Frog  1008 HQKKIMNSIQEM 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	63/185 (34%)
		FN3	387..476	CDD:238020	27/98 (28%)
		FN3	536..623	CDD:238020	21/86 (24%)
		EphA2_TM	640..738	CDD:464211	31/114 (27%)
		PTKc_EphR	736..1002	CDD:270629	190/266 (71%)
		SAM_1	1029..1092	CDD:425739	23/62 (37%)
epha5	XP_012810832.1	EphR_LBD_A5	64..236	CDD:198451	63/186 (34%)
		FN3	<359..>601	CDD:442628	70/287 (24%)
		FN3	473..563	CDD:238020	23/91 (25%)
		EphA2_TM	580..665	CDD:464211	31/114 (27%)
		PTKc_EphR_A	663..929	CDD:270651	190/267 (71%)
		SAM_EPH-A5	958..1023	CDD:188945	22/62 (35%)