DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eph and epha8

DIOPT Version :9

Sequence 1:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster
Sequence 2:XP_031758381.1 Gene:epha8 / 100487286 XenbaseID:XB-GENE-5915618 Length:979 Species:Xenopus tropicalis


Alignment Length:1063 Identity:418/1063 - (39%)
Similarity:591/1063 - (55%) Gaps:153/1063 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 LLIIISIHFKLA-----HADQVVLLDTTREATL--EWTRYPYGPQAQTPGW-----VEESFTDFV 121
            |..::.:.|.||     .:::|.||:|   ||:  :|....|.|.    ||     ::|.|:.. 
 Frog     5 LACLLCVCFSLAPCSAPSSNEVNLLET---ATIPGDWGWLTYPPH----GWDSISEMDEFFSPI- 61

  Fly   122 KGINWRSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFY 186
                 .:|.||:|...|.||||.:.::.|..|.|:|:|::||:|||:..||.:.:|||||:|.:.
 Frog    62 -----HTYQVCNVMSPNQNNWLRTNWVARDGARRVYVEVKFTLRDCNSMPGVSGTCKETFNLFYL 121

  Fly   187 EFD----AATREPPPWQTDSYRLIARIAAGEGRFNQNSDV---DINTEVKSIA-VNKKGVYFAFR 243
            |.|    ..|      |.:.:..|..|||.|...|.:..|   .:||||:.:. ::::|.|.||:
 Frog   122 ESDRDLGTGT------QQNHFMKIDTIAADESFTNVDLGVRKLKLNTEVRGVGPLSRRGFYLAFQ 180

  Fly   244 DQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYLCKGDG 308
            |.||||::::|:|||..||.:..|.|.|.|..||.:.:.:.:..|.||.|:|..:.|...|..:|
 Frog   181 DIGACIAIVSVRVYYKKCPPMVRNLAAFTEAVTGSDSSSLVEVQGECVGNSEERDPPKMYCSSEG 245

  Fly   309 KWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKS-PEVTKCTPCPPNSNASKTGSPFCKCASGFY 372
            :|.:..|.|.|.||:|..  :.:|..|.||.:|| |...:|..|||.|::....:..|.|.:.:|
 Frog   246 EWLVPIGKCVCSAGFEER--SDSCVACDLGYYKSFPGDQRCYKCPPFSHSETLAAQLCPCGTNYY 308

  Fly   373 RHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI---- 433
            |...|....||..||:.|.|| :..|:.||..:.|:.|..:..          ..|:.|.:    
 Frog   309 RSATDPPSAPCTRPPSGPENL-ISSVNGTSVSLDWTPPLDSGG----------RRDVTYNVICRR 362

  Fly   434 ------KCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSL 492
                  :|..|...|.|.|.......|.:|:.||:....||..:.|.|.||..:...|       
 Frog   363 CAWDAGQCEPCGGGVRYTPQQMGLARTSLTVANLQAHMNYTFWVEATNGVSDFSLEPR------- 420

  Fly   493 VAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQS 557
                  :||:.::                   ||.....|.|..:|..........|.|.:|.|.
 Frog   421 ------MFSSVNI-------------------TTNQAAPSQVLAIRHQKAWQTSISLLWPEPEQP 460

  Fly   558 DFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQ 622
            :..:..||::::.|.: :..:.|.|..|||:|.:.||...|.|.||||.:|:.|.|.:|..:..:
 Frog   461 NGVILEYEIKYYEKGQ-EMHSYSTLRAKETRAIVSGLKPGTHYVFQVRARTSAGCGRFSPTVEVE 524

  Fly   623 TLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKH-------QDDLDKKSTN-HLP 679
            |.:::...|:... |.:|...::||::     |:.:|...:.:|       ||..:||..| |:.
 Frog   525 TSKAMALRYNTRT-IVWICLILITGLV-----ILLSVLICKKRHCGYSKAFQDSDEKKLQNGHIT 583

  Fly   680 LPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIE 744
            |                              ..|:.||||||||||.||:|:|||||:|:.|.||
 Frog   584 L------------------------------AASKLYVDPHTYEDPCQAVRDFAREIEASRIRIE 618

  Fly   745 AIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQG 809
            .|||.||||:||.||||:|..  ::|.|||||||.|.|||.|.|||:|||||.||||||:|.|:|
 Frog   619 KIIGSGEFGEVCYGRLKVPGK--REIPVAIKTLKAGYSEKQRRDFLSEASIMAQFDHPNIIRLEG 681

  Fly   810 VVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNV 874
            |||||...||:||||||||||:||:..||:|..:||:.|||||::||.||||:.|:||||||||:
 Frog   682 VVTRSKLTMIVTEYMENGSLDSFLKSRDGQFNIIQLVGMLRGISAGMKYLSDLGYIHRDLAARNI 746

  Fly   875 LVNAQLICKIADFGLSREIENASD-AYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEV 938
            |||..::||::||||||.:|:..| ||||.|||||:||||||||.:|||:|||||||:|:|:|||
 Frog   747 LVNNNMVCKVSDFGLSRILEDDPDAAYTTTGGKIPIRWTAPEAITYRKFSSASDVWSFGIVMWEV 811

  Fly   939 MSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLA 1003
            ::||||||||.:|:|||.|:|:||||||||.||.||:||||||||:.|..||.|:.|||.|||..
 Frog   812 LAYGERPYWNMTNRDVINSVEEGYRLPAPMGCPAALHQLMLDCWQRDRNERPRFSLIVSVLDNFL 876

  Fly  1004 RQPQSL-----LTTRPSPESDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKEANLINAQQI 1063
            |.|::|     ::....|..|..|:     ..:...|.|.||:.|||.||..:|......:...:
 Frog   877 RNPENLKASATVSRFTHPRLDRGHL-----DVSSCASVDAWLDSIKMGRYKENFLMGGYSSLGLV 936

  Fly  1064 SRLTAQQLSDMGITLVGHQKKIL 1086
            .|:..:.:..:||:|||||||||
 Frog   937 MRMNIEDIRQLGISLVGHQKKIL 959

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 68/189 (36%)
FN3 387..476 CDD:238020 23/98 (23%)
FN3 536..623 CDD:238020 26/86 (30%)
EphA2_TM 644..736 CDD:291255 29/99 (29%)
PTKc_EphR 736..1002 CDD:270629 181/266 (68%)
Pkinase_Tyr 741..999 CDD:285015 177/258 (69%)
SAM_1 1033..1092 CDD:278937 22/54 (41%)
SAM 1039..1092 CDD:197735 20/48 (42%)
epha8XP_031758381.1 EphR_LBD 25..197 CDD:413445 68/190 (36%)
FN3 323..429 CDD:238020 29/148 (20%)
FN3 434..525 CDD:238020 28/91 (31%)
EphA2_TM 541..612 CDD:405290 32/105 (30%)
PKc_like 610..876 CDD:419665 182/267 (68%)
SAM_EPH-A8 905..969 CDD:188949 22/55 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 397 1.000 Domainoid score I749
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 763 1.000 Inparanoid score I545
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D397694at33208
OrthoFinder 1 1.000 - - FOG0000086
OrthoInspector 1 1.000 - - otm49458
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X82
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
99.070

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