DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eph and ephb1

DIOPT Version :9

Sequence 1:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster
Sequence 2:	XP_017207747.1	Gene:	ephb1 / 100333537	-ID:	-	Length:	1011	Species:	Danio rerio

Alignment Length:	1079	Identity:	460/1079 - (42%)
Similarity:	627/1079 - (58%)	Gaps:	130/1079 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 MSLLRTILLIIISIHFKLAHADQVVLLDT-TREATLEWTRYPYGPQAQTPGWVEESFTDFVKGIN 125
            |....|:.||.|.......:|.:..|:|| |..|.|.||.||      :.||.|.|..|  :.:|
Zfish     1 MPFTMTVGLITILSAVTAVYAMEETLMDTRTATAELGWTAYP------SSGWEEVSGYD--ENLN 57

  Fly   126 W-RSYVVCDVAYHNVNNWLWSPFIDRGSANRLYIEIQFTIRDCSLFPGNALSCKETFSLLFYEFD 189
            . |:|.||:|...|.||||.:.||.|..|.|:|:|::||:||||..|....||||||:|.:||.|
Zfish    58 TIRTYQVCNVFESNQNNWLLTTFIARRGAQRIYVEMRFTVRDCSSIPRVPGSCKETFNLYYYETD 122

  Fly   190 A--ATREPPPWQTDSYRLIARIAAGEGRFNQNSDVD-------INTEVKSIA-VNKKGVYFAFRD 244
            :  ||:....|....|..:..|||.|. |:|   ||       :||||:|.. ::|.|.|.||:|
Zfish   123 SVIATKGTAFWMEAPYLKVDTIAADES-FSQ---VDFGGRLMKVNTEVRSFGPLSKNGFYLAFQD 183

  Fly   245 QGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPYETPTYL-CKGDG 308
            .|||:|:|:|:|:|..||:|.:|||.|.||.||.|.|.:....|.|:.|:|..:.|..| |.|||
Zfish   184 YGACMSLLSVRVFYKKCPSVVQNFAIFPETMTGAESTSLVIARGMCIPNSEEVDVPIKLYCNGDG 248

  Fly   309 KWTILTGGCRCKAGYEPNYTNKTCTECPLGTFKSPE-VTKCTPCPPNSNASKTGSPFCKCASGFY 372
            .|.:..|.|.||||:||:..| .|..||.||||:.: ...|:.||.||.::...:..|.|.:|:|
Zfish   249 DWMVPIGSCTCKAGFEPDNGN-ICRACPPGTFKASQGPGLCSQCPANSRSTSEAATICVCRNGYY 312

  Fly   373 RHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKI---- 433
            |...:...|||.|.|:.|.|: :..|::||..:.|.:|       .||..:   .|:.|.|
Zfish   313 RADGEQPDMPCTSVPSGPRNV-ISIVNETSVTLEWHSP-------RETGGR---EDVTYNIVCKK 366

  Fly   434 ------KCNICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSL 492
                  .|:.|..||.:.|......|:::.::||...|.||.:|.|:|.|         ||:|..
Zfish   367 CQADRRSCSHCDDNVEFQPRQLGLTESRVFISNLLAHTLYTFEIQAVNGV---------SNKSPY 422

  Fly   493 VAVSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQS 557
            .|           .::.:|:            ||.....|.|..:..::.|.|...|.|.:|.|.
Zfish   423 PA-----------QHVSIDI------------TTNQAAPSIVPIMHQVSSTMKSITLSWPQPEQP 464

  Fly   558 DFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQ 622
            :..:..||:|::.| ||..:|.:.:.::...|.:.||...|.|..|||.:|..|||.||:.:..|
Zfish   465 NGIILDYELRYYEK-ELSEVNSTQMRSQTNTARVDGLRPGTMYVMQVRARTVAGFGKYSSKMCFQ 528

  Fly   623 TLQSVGSVYDDSV------QIRFIAGAIVTGVLFLVIFIIATVYFMRSK-------HQDDLDKKS 674
            ||.      ||..      |:..|||:...||:|:|..:..::...|.:       :.|.|...|
Zfish   529 TLT------DDDYKSELREQLPLIAGSAAAGVVFIVSLVAISIVCRRKRAYNKEAVYSDKLQHYS 587

  Fly   675 TNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNS---RSYVDPHTYEDPNQAIREFAREI 736
            |.             ..:...|.:...|..:..|....|   :.|:||.||||||:|:||||:||
Zfish   588 TG-------------RELTLRPDLSNCHTPMGCPTLPGSPGMKIYIDPFTYEDPNEAVREFAKEI 639

  Fly   737 DANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDH 801
            |.:.:.||.:||.||||:|.:||||:|..  :::.|||||||.|.|||.|.|||:||||||||||
Zfish   640 DVSTVKIEEVIGAGEFGEVYKGRLKLPGK--RELYVAIKTLKAGYSEKQRRDFLSEASIMGQFDH 702

  Fly   802 PNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVH 866
            ||:|.|:||||:|.||||:||:||||:||:|||.|||:|..:||:.||||||:||.|||:|||||
Zfish   703 PNIIRLEGVVTKSRPVMIVTEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVH 767

  Fly   867 RDLAARNVLVNAQLICKIADFGLSREI-ENASD-AYTTR-GGKIPVRWTAPEAIAFRKFTSASDV 928
            |||||||:|||:.|:||::||||||.: |:.|| .||:. |||||||||:|||||:|||||||||
Zfish   768 RDLAARNILVNSNLVCKVSDFGLSRYLQEDTSDPTYTSSLGGKIPVRWTSPEAIAYRKFTSASDV 832

  Fly   929 WSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFA 993
            ||||:|:|||||:||||||:.||||||.:||:.||||.|||||.||:|||||||||.|..||.|.
Zfish   833 WSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPTALHQLMLDCWQKDRNARPRFT 897

  Fly   994 SIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQRGQNI-----FISTDLWLEHIKMSRYCHHFK 1053
            .||:|||.|.|.|.||......|......:||    ::|     |.|.:.||..:|||:|..:|.
Zfish   898 DIVNTLDKLIRNPTSLKAVASIPTIPSQPLLD----RSIPDFTTFSSVEDWLAAVKMSQYRDNFL 958

  Fly  1054 EANLINAQQISRLTAQQLSDMGITLVGHQKKILHQARQL 1092
            .:...:.|.::::|::.|..:|:||.|||||||:..:.:
Zfish   959 NSGFTSLQLVTQMTSEDLLRIGVTLAGHQKKILNSIQSM 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	81/186 (44%)
		FN3	387..476	CDD:238020	26/98 (27%)
		FN3	536..623	CDD:238020	27/86 (31%)
		EphA2_TM	644..736	CDD:291255	27/101 (27%)
		PTKc_EphR	736..1002	CDD:270629	187/268 (70%)
		Pkinase_Tyr	741..999	CDD:285015	182/260 (70%)
		SAM_1	1033..1092	CDD:278937	22/58 (38%)
		SAM	1039..1092	CDD:197735	20/52 (38%)
ephb1	XP_017207747.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	396	1.000	Domainoid score	I723
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20936
Inparanoid	1	1.050	753	1.000	Inparanoid score	I540
OMA	1	1.010	-	-		QHG45908
OrthoDB	1	1.010	-	-		D397694at33208
OrthoFinder	1	1.000	-	-		FOG0000086
OrthoInspector	1	1.000	-	-		otm24639
orthoMCL	1	0.900	-	-		OOG6_100189
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8646
SonicParanoid	1	1.000	-	-		X82
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910