Protein Alignment Eph and erbb4a

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: NP_001137223.2
• Gene: erbb4a / 100007677
• ZFINID: ZDB-GENE-030918-4
• Length: 1421
• Species: Danio rerio
• Alignment Length: 1054
• Identity: 255/1054 - (24%)
• Similarity: 399/1054 - (37%)
• Gaps: 276/1054 - (26%)

  Fly   151 GSANRL---------YIEIQFTIRDCSLFPGN--ALSCKETFSLLFYEFDAATREPPPWQTDSYR 204
            |:.|:|         |..::....:|.:..||  ..|.:...:|.|.:   :.||     ...|.
Zfish    37 GTDNKLSTLSDLDQQYKTLRKFYENCEVVMGNLEITSIERNRNLSFLK---SIRE-----VTGYV 93

  Fly   205 LIA------------RIAAG----EGRFNQNSDVDINTEVKSIAV---NKKGVYFAFRDQGA--C 248
            |:|            ||..|    |||:             |:|:   .::..||..|..|.  .
Zfish    94 LVALNQFDYLPLENLRIIRGTKLYEGRY-------------SLAIFLNYRRDGYFGLRQLGLKNL 145

  Fly   249 ISVLAVKVYY----ITCPAVTENFAHFNETPTGREITIIEKQ-------------NGTCVDNAEP 296
            ..:|...||.    ..|.|.|.::....:.|.. |:.::...             ||.|..:.|.
Zfish   146 TEILNGGVYVDQNKFLCHADTIHWHDIIKNPRS-ELLVVPSNNSGNTCRRCHRSCNGRCWGHQED 209

  Fly   297 YETPTYLCKGDGKWTILTGGC--RCKAGYEPNYTNKTCTECPLGTFKSPEVTKCTPCPPNSNASK 359
            .      |:...| |:....|  ||...|..|..::   ||..|.| .|:.|.|..|   :|.:.
Zfish   210 Q------CQSLTK-TVCAEQCDGRCFGPYVSNCCHR---ECAGGCF-GPKDTDCFAC---TNFND 260

  Fly   360 TGSPFCKCASGFYRHPNDGR--HMP-------CYSPPAAPTNLTLLFVDQTSAIISWSAPA-KNE 414
            :|:...:|...|..:|...:  |.|       .:.....|.|..   ||.:|.:  .:.|: |.|
Zfish   261 SGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCPHNFV---VDHSSCV--RACPSNKME 320

  Fly   415 SFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTDTFN-ETKITLTNLEPVTTYTV------QIH 472
            ...::|...|..:||..|:...|.:.::....:.|:.| |..:..|.:.....:.:      ..|
Zfish   321 VEENQTKMCIPCTDICPKVCDGIGTGSLQMAQTVDSSNIEKFVNCTKINGNLIFLITGIKGDMFH 385

  Fly   473 AINSV--SHINEFKR-------------HSNESSLVAVSDI-------VFSNTSLLNIP------ 509
            .|.::  ..:|.|:.             ..|.:.|...|::       ::|..|||.:.
Zfish   386 GIRALDPDRLNVFRTVREITGFLNVQSWPENMTDLGVFSNLATIGGRSLYSGISLLILKQRWITS 450

  Fly   510 ---LDLNEVKTGQAEIVFTTESVLLSTV-------FNLRILAITNKDADLEWDK------PVQSD 558
               ..|.|:..|...:...::....|||       .:.:...|.|.....|..|      |:.|:
Zfish   451 LQFQSLREISAGNVYMTNNSQLCFYSTVNWTSLFRTSTQRALIKNNREPRECSKEQKICDPLCSE 515

  Fly   559 --------------------------FPLEFYEVRWFPK----VELDAINKSALNTKETKAHIVG 593
                                      ..|.:.:||.|..    ||.|        ::..||...|
Zfish   516 AGCWGPGPDQCLSCKYFSRGKTCVKSCNLYYGDVREFANGSVCVECD--------SQCEKAGEKG 572

  Fly   594 LLENTEYG----FQVRC-----------KTNNGFGSYSNMI--YAQTLQS------------VGS 629
            |   |.:|    ..|:|           |..:|....::.|  ||:|...            .|.
Zfish   573 L---TCHGPGPDHCVKCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQGCTGP 634

  Fly   630 VYDDSVQI----RFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVN 690
            ...|.|.|    ..||..::.|:..:||..:....::|.|   .:.||..
Zfish   635 RIQDCVGILDRTPLIAAGLIGGLFVIVIIALGVAVYIRRK---SIKKKRA--------------- 681

  Fly   691 SMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDV 755
                  :.:.|...:..||..:..:         ||||.....:|.:...:   .|:|.|.||.|
Zfish   682 ------LRRFLETELVEPLTPSGAA---------PNQAQLRILKETELKRV---KILGAGAFGMV 728

  Fly   756 CRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMII 820
            .:| :.:|......|.||||.|...:..||..:|:.||.||...:||:::.|.||.. |..:.::
Zfish   729 YKG-IWVPEGETVKIPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCL-SPTIQLV 791

  Fly   821 TEYMENGSLDTFLRVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIA 885
            |:.|.:|.|..::..:.....:..|:.....||.||.||.:...||||||||||||.:....||.
Zfish   792 TQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKIT 856

  Fly   886 DFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWS 950
            ||||:|.::.....|.:.|||:|::|.|.|.|.:||||..||||||||.:||:|::|.:||....
Zfish   857 DFGLARLLDTDEKEYNSDGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIP 921

  Fly   951 NQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTLDNLARQPQSLLTTR-- 1013
            .:|:...:|||.|||.|..|...:|.:|:.||......||.|..:.:....:||.||..|..:
Zfish   922 TRDIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGD 986

  Fly  1014 -----PSPESDGNH 1022
                 |||    ||
Zfish   987 DRMKLPSP----NH 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	30/144 (21%)
		FN3	387..476	CDD:238020	20/96 (21%)
		FN3	536..623	CDD:238020	26/139 (19%)
		EphA2_TM	640..738	CDD:464211	17/97 (18%)
		PTKc_EphR	736..1002	CDD:270629	100/265 (38%)
		SAM_1	1029..1092	CDD:425739
erbb4a	NP_001137223.2	Recep_L_domain	61..173	CDD:460032	29/132 (22%)
		Furin-like	190..338	CDD:395614	39/166 (23%)
		Recep_L_domain	364..484	CDD:460032	18/119 (15%)
		GF_recep_IV	508..639	CDD:464344	24/141 (17%)
		TM_ErbB4	638..681	CDD:213053	12/45 (27%)
		Protein Kinases, catalytic domain	706..1002	CDD:473864	111/300 (37%)