Protein Alignment Eph and ddr1

DIOPT Version :10

• Sequence 1: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Sequence 2: XP_009290548.1
• Gene: ddr1 / 100007346
• ZFINID: ZDB-GENE-060323-2
• Length: 974
• Species: Danio rerio
• Alignment Length: 748
• Identity: 185/748 - (24%)
• Similarity: 292/748 - (39%)
• Gaps: 246/748 - (32%)

  Fly   446 PSTDT---FNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSN------------ESSLVA- 494
            |:.|.   |.:|:|         .:|:|:|:.|         ||:.            ::||::
Zfish   271 PTVDIEFHFEKTRI---------FHTMQVHSNN---------RHTQGVRVFSEVVCKFKASLLSP 317

  Fly   495 ---------VSDIVFSNTSLLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLE 550
                     |||:...::..:::||.....:..:....|....:|:|   .:...::..:|..:.
Zfish   318 WAEPELSLQVSDLHDLSSRTISLPLGGRPAQILRCHFAFADNWLLIS---EISFYSMPFEDGSVL 379

  Fly   551 WDKPVQSDFPLEFYEVRWFPKVELDAINKSALNTKETKAHIVGLLENTEYGFQVRCKTNNGF--G 613
            ...|..|..|             |:|.:.|.:....|.:....|:            ||:..  .
Zfish   380 PPIPSSSSRP-------------LNATSYSPITANATSSPTNLLM------------TNSSLLPS 419

  Fly   614 SYSNMIYAQTLQ-SVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYF------MRSKHQDDLD 671
            |....:...||: .:....|||.....:.|.:| |::.|::.:|..:.:      :..|.|..|.
Zfish   420 SMPTEMSGITLRVGIPVAKDDSSHTAILIGCLV-GIILLLLAVIVVILWRQYWKKLLGKAQGSLS 483

  Fly   672 KKSTN-HLPLPLD-----------YAS-------------NEVNSMDTTPIVKKLHLNVTTPLFG 711
            ..... ||.:|.|           |:|             .|....:.:.:::......:|.|..
Zfish   484 SDELRVHLSVPSDNVVINNTNTHTYSSRYQRIHTFPDDRDREGEYQEPSTVLRPRDQRDSTALLL 548

  Fly   712 NSRSY-----------------------------------VD----------------------- 718
            |:.:|                                   ||
Zfish   549 NNPAYHLLLSDLTHGPNRLTNCHSQQEKPLNLSQACAIDMVDKGLPIQEGPPPYPGAPPPGLSGA 613

  Fly   719 ------------PH----------------TYEDPNQA--------IREFAREIDANYITIEAII 747
                        ||                ||..|..:        :.|..||    .:..:..:
Zfish   614 HYGEASGGGASVPHYAEADIISLQGVSGNNTYAVPALSATPTDCPPLPELPRE----RLVFKEKL 674

  Fly   748 GGGEFGDV--CR-------GRLKIPPNF--VQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDH 801
            |.|:||:|  |.       ..|:.|.|.  .:.:.||:|.|:|.:|:.||.|||.|..|:.:...
Zfish   675 GEGQFGEVHLCEIENPQDLANLEFPFNVRKGRPLLVAVKILRPDASKNARNDFLKEVKILSRLKD 739

  Fly   802 PNVIYLQGVVTRSNPVMIITEYMENGSLDTFL--RV---NDGKFQTL------QLIVMLRGIASG 855
            ||:|.|.||...|:|:.::|||||:|.|:.:|  ||   ..|..|..      .||.|...||||
Zfish   740 PNIIRLLGVCVSSDPLCMVTEYMESGDLNQYLSHRVLLDKSGPSQNTPTISYPALISMASQIASG 804

  Fly   856 MSYLSDMNYVHRDLAARNVLV----------NAQLICKIADFGLSREIENASDAYTTRG-GKIPV 909
            |.:|:.:|:||||||.||.||          ..:...||||||:||.: .|.|.|..:| ..:|:
Zfish   805 MKFLASLNFVHRDLATRNCLVGGERGESEERGGERHIKIADFGMSRNL-YAGDYYRIQGRAVLPI 868

  Fly   910 RWTAPEAIAFRKFTSASDVWSYGVVLWEVMSY-GERPYWNWSNQDVIKSIEKGYR-------LPA 966
            ||.|.|.|...|||:|||||::||.|||::|. .|:||.:.:::.||.:..:.:|       |..
Zfish   869 RWMAWECILMGKFTTASDVWAFGVTLWEMLSVCQEQPYSHMTDEQVIDNAGEFFRDQGRQVYLSR 933

  Fly   967 PMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL 999
            |..||:.||:|||.||.:....||:||.|.|.|
Zfish   934 PAVCPQGLYELMLSCWNRDCKLRPSFAYIHSFL 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	8/32 (25%)
		FN3	536..623	CDD:238020	12/88 (14%)
		EphA2_TM	640..738	CDD:464211	29/222 (13%)
		PTKc_EphR	736..1002	CDD:270629	118/305 (39%)
		SAM_1	1029..1092	CDD:425739
ddr1	XP_009290548.1	FA58C	37..188	CDD:238014
		Protein Kinases, catalytic domain	662..968	CDD:473864	121/310 (39%)