DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1909 and rapsn

DIOPT Version :9

Sequence 1:	NP_651928.1	Gene:	CG1909 / 43800	FlyBaseID:	FBgn0039911	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_840090.1	Gene:	rapsn / 352942	ZFINID:	ZDB-GENE-030313-1	Length:	412	Species:	Danio rerio

Alignment Length:	413	Identity:	123/413 - (29%)
Similarity:	211/413 - (51%)	Gaps:	19/413 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 KRKIERGRRLYEQNNQTEAVRTWRSALKGTCQREDCFQLLGYLYQAHMDWGKFREAIEFSHQQLG 159
            |::||:|.:||:.|:..:|:..|...|:.|......|::||.|..||.:.||::|.::||..|:.
Zfish     7 KQQIEKGLKLYQSNDTEKALYVWMKVLRKTSDPGGKFRVLGCLITAHSEMGKYKEMLQFSLAQIN 71

  Fly   160 ISEELDSPNMRAETYLNLSRAHASLGGLERSLSYARHSLYNECGTKCR---SGLVHLTVARVYLE 221
            .:.|::.|:...|.||||:|::..|...::::||....| |..||...   :|.|.|::...||.
Zfish    72 TAREMEDPDYLTEGYLNLARSNEKLCDFQKTVSYCETCL-NMQGTTVSLQLNGQVCLSMGNAYLG 135

  Fly   222 MGGFSRALEGLQGAYKIATAIGDPSLELQVYVALSELFGRLQDNDKSATYASKAYDLSRSLQLGD 286
            :..|.:||...:.|.:.|....|..||.:|..:|...:.:|:|.:|:..:..||.:|......|
Zfish   136 LSVFQKALVSYEKALRYAHNNDDKMLECRVCCSLGNFYIQLKDFEKALFFPCKAAELVNDYGKG- 199

  Fly   287 LNSCHHRA-ALLRMAVSLRKQGELGDAQDYCKEATKLSLISGDQATYTRSIRVMGDIYRNKMDMD 350
             .|..:|| :...|:|:.:|...|.||.:.|:|:.|::|..||:......:....||:|.:.|:|
Zfish   200 -WSLKYRAMSQYHMSVAYKKLMRLPDAMECCEESMKIALQHGDRPLQALCLLNFADIHRCQKDVD 263

  Fly   351 RAFRQYEQAMGTSASLGDRMAQMEAMDGAARCLETLRLQNKICNCRPLEFNTRLLEVASSIGAKF 415
            :||.:||.:|...:.:|:|:.|.....|..:|....:..:|     .|:...|..::|.:||.|.
Zfish   264 KAFPRYESSMCIMSEIGNRLGQASIYVGVGKCWILQKEYDK-----ALDSLQRANDLAEAIGNKL 323

  Fly   416 LVRKIRCRLALIYRALGDEDQYNTHFRLANQTDAALGLNCGACGELLGLRPENLEALPCAHILHA 480
            .:.|:......|||....:::.........|....|.|.||.|||.:|.:.:.|:||||:||.|.
Zfish   324 CILKVHSLCEGIYRCKEQQEELREQVVKFLQCVEELELYCGMCGESIGEKNQQLQALPCSHIFHL 388

  Fly   481 RCAYEILRRREKNAPRSCPACNK 503
            :|.       :.|..:.||.|::
Zfish   389 KCL-------QTNGTKGCPKCHR 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1909	NP_651928.1	SNAP	89..168	CDD:305195	24/72 (33%)
		TPR repeat	94..122	CDD:276809	9/26 (35%)
		TPR repeat	127..164	CDD:276809	12/36 (33%)
		TPR repeat	171..198	CDD:276809	9/26 (35%)
		TPR repeat	211..237	CDD:276809	8/25 (32%)
		TPR repeat	248..278	CDD:276809	8/29 (28%)
		TPR_12	249..322	CDD:290160	20/73 (27%)
		TPR repeat	293..321	CDD:276809	10/28 (36%)
		TPR repeat	333..360	CDD:276809	9/26 (35%)
rapsn	NP_840090.1	Rapsyn_N	1..80	CDD:287540	24/72 (33%)
		TPR repeat	84..111	CDD:276809	10/27 (37%)
		TPR_11	124..192	CDD:290150	19/67 (28%)
		TPR repeat	124..151	CDD:276809	8/26 (31%)
		TPR repeat	156..192	CDD:276809	10/35 (29%)
		TPR repeat	197..234	CDD:276809	12/38 (32%)
		TPR_12	204..270	CDD:290160	21/65 (32%)
		TPR_12	242..318	CDD:290160	19/80 (24%)
		TPR repeat	246..270	CDD:276809	7/23 (30%)
		TPR repeat	286..312	CDD:276809	4/30 (13%)
		zf-RING_11	363..391	CDD:293728	14/27 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589061
Domainoid	1	1.000	59	1.000	Domainoid score	I10723
eggNOG	1	0.900	-	-		E1_KOG1941
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3708
Inparanoid	1	1.050	192	1.000	Inparanoid score	I3846
OMA	1	1.010	-	-		QHG46428
OrthoDB	1	1.010	-	-		D1245397at2759
OrthoFinder	1	1.000	-	-		FOG0008407
OrthoInspector	1	1.000	-	-		oto39465
orthoMCL	1	0.900	-	-		OOG6_109777
Panther	1	1.100	-	-	LDO	PTHR46574
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3640
SonicParanoid	1	1.000	-	-		X6398
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840