DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1909 and Rapsn

DIOPT Version :9

Sequence 1:	NP_651928.1	Gene:	CG1909 / 43800	FlyBaseID:	FBgn0039911	Length:	606	Species:	Drosophila melanogaster
Sequence 2:	NP_033049.2	Gene:	Rapsn / 19400	MGIID:	99422	Length:	412	Species:	Mus musculus

Alignment Length:	413	Identity:	124/413 - (30%)
Similarity:	215/413 - (52%)	Gaps:	19/413 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 KRKIERGRRLYEQNNQTEAVRTWRSALKGTCQREDCFQLLGYLYQAHMDWGKFREAIEFSHQQLG 159
            |::||:|.:||:.|...:|::.|...|:........|::||.|..||.:.|:::|.::|:..|:.
Mouse     7 KQQIEKGLQLYQSNQTEKALQVWMKVLEKGSDLVGRFRVLGCLVTAHSEMGRYKEMLKFAVVQID 71

  Fly   160 ISEELDSPNMRAETYLNLSRAHASLGGLERSLSYARHSLYNECGTKCRS---GLVHLTVARVYLE 221
            .:..|:..:...|:||||:|::..|....:::||.:..| ...||:..:   |.|.|::...:|.
Mouse    72 TARGLEDADFLLESYLNLARSNEKLCEFHKTISYCKTCL-GLPGTRAGAQLGGQVSLSMGNAFLG 135

  Fly   222 MGGFSRALEGLQGAYKIATAIGDPSLELQVYVALSELFGRLQDNDKSATYASKAYDLSRSLQLGD 286
            :..|.:|||..:.|.:.|....|..||.:|..:|...:.:::|.:|:..:..||.:|......|
Mouse   136 LSLFQKALESFEKALRYAHNNDDTMLECRVCCSLGSFYAQVKDYEKALFFPCKAAELVNDYGKG- 199

  Fly   287 LNSCHHRA-ALLRMAVSLRKQGELGDAQDYCKEATKLSLISGDQATYTRSIRVMGDIYRNKMDMD 350
             .|..:|| :...|||:.|..|.||.|.:.|:|:.|::|..||:......:....||:|::.|::
Mouse   200 -WSLKYRAMSQYHMAVAYRLLGHLGSAMECCEESMKIALQHGDRPLQALCLLCFADIHRSRGDLE 263

  Fly   351 RAFRQYEQAMGTSASLGDRMAQMEAMDGAARCLETLRLQNKICNCRPLEFNTRLLEVASSIGAKF 415
            .||.:|:.||.....:|:|:.|:..:.|.|:|....::|:|     .|:...:..::|..:|.|.
Mouse   264 TAFPRYDSAMSIMTEIGNRLGQVHVLLGVAKCWMARKVQDK-----ALDAIEKAQDLAEEVGNKL 323

  Fly   416 LVRKIRCRLALIYRALGDEDQYNTHFRLANQTDAALGLNCGACGELLGLRPENLEALPCAHILHA 480
            ...|:.|....|||:.|.:.:..||....::......|.||.|||.:|.|...|:||||:||.|.
Mouse   324 SQLKLHCLSESIYRSKGLQRELRTHVVRFHECVEETELYCGLCGESIGERNSRLQALPCSHIFHL 388

  Fly   481 RCAYEILRRREKNAPRSCPACNK 503
            ||.       :.|..||||.|.:
Mouse   389 RCL-------QNNGTRSCPNCRR 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1909	NP_651928.1	SNAP	89..168	CDD:305195	21/72 (29%)
		TPR repeat	94..122	CDD:276809	9/26 (35%)
		TPR repeat	127..164	CDD:276809	10/36 (28%)
		TPR repeat	171..198	CDD:276809	9/26 (35%)
		TPR repeat	211..237	CDD:276809	8/25 (32%)
		TPR repeat	248..278	CDD:276809	7/29 (24%)
		TPR_12	249..322	CDD:290160	21/73 (29%)
		TPR repeat	293..321	CDD:276809	12/28 (43%)
		TPR repeat	333..360	CDD:276809	7/26 (27%)
Rapsn	NP_033049.2	SNAP	1..80	CDD:329252	21/72 (29%)
		TPR 1	6..39		10/31 (32%)
		TPR	<9..239	CDD:223533	68/232 (29%)
		TPR 2	83..116		11/33 (33%)
		TPR 3	123..156		10/32 (31%)
		TPR repeat	127..151	CDD:276809	7/23 (30%)
		TPR repeat	156..192	CDD:276809	9/35 (26%)
		TPR 4	163..196		7/32 (22%)
		TPR repeat	197..234	CDD:276809	14/38 (37%)
		TPR_12	204..278	CDD:315987	25/73 (34%)
		TPR 5	206..239		13/32 (41%)
		TPR 6	246..279		9/32 (28%)
		TPR repeat	246..274	CDD:276809	8/27 (30%)
		TPR 7	286..319		7/37 (19%)
		RING-H2_Rapsyn	360..404	CDD:319392	24/50 (48%)
		RING-H2 finger (C3H2C3-type)	363..402	CDD:319392	22/45 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844098
Domainoid	1	1.000	47	1.000	Domainoid score	I12007
eggNOG	1	0.900	-	-		E1_KOG1941
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3708
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3736
Isobase	1	0.950	-	0	Normalized mean entropy	S5384
OMA	1	1.010	-	-		QHG46428
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008407
OrthoInspector	1	1.000	-	-		oto93093
orthoMCL	1	0.900	-	-		OOG6_109777
Panther	1	1.100	-	-	LDO	PTHR46574
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6398
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.710