DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17698 and SAK1

DIOPT Version :9

Sequence 1:	NP_001036633.2	Gene:	CG17698 / 4379919	FlyBaseID:	FBgn0040056	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_011055.3	Gene:	SAK1 / 856866	SGDID:	S000000931	Length:	1142	Species:	Saccharomyces cerevisiae

Alignment Length:	497	Identity:	147/497 - (29%)
Similarity:	226/497 - (45%)	Gaps:	123/497 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 SNKPNKMKKCLDYESVKRYPCKVSNEPPQHNTASKPQILYETRPIYPNVPYSPYST-PFSSPRSS 257
            |:..:.:...|:.:.|::.      ..|||.           :.|..::..:|.:| .|.|..||
Yeast    60 SSSVDSLNMLLERQRVRQL------NHPQHQ-----------QHISSSLAKTPTTTSSFCSSGSS 107

  Fly   258 RRKPAFRESRRISI--DKSGSFLQLNQYRLMEQIGQGSYGLVKLAYSEEDSTHYAMKILSKKRLL 320
            :.|  .:|:.|||:  |.......||.|.:::::|.|.:|.||||.........|:||:.:.. .
Yeast   108 KNK--VKETNRISLTYDPVSKRKVLNTYEIIKELGHGQHGKVKLARDILSKQLVAIKIVDRHE-K 169

  Fly   321 RQAGLMRRGPRKATSPLDRVYREIAVLKKLDHPNVVKLVEVLDDPLEDSLYMVFELVKQGEVLRI 385
            :|............|..|::.||||::||..|.:||:|:|||||.....:|:|.|...:|||...
Yeast   170 KQRKFFTFIKSSKISENDKIKREIAIMKKCHHKHVVQLIEVLDDLKSRKIYLVLEYCSRGEVKWC 234

  Fly   386 PTD---------NPLSEKRAWSIFRESLLGLEYYTMLSSSAISLKRIFVYTVHHQKIIHADIKPG 441
            |.|         :.||.:....|.|..:|||||                  :|:|.|||.||||.
Yeast   235 PPDCMESDAKGPSLLSFQETREILRGVVLGLEY------------------LHYQGIIHRDIKPA 281

  Fly   442 NLLLTEFGHVKIADLGVCNEFLGDDATISNGS-----------TAGTPAFRAPETL--------- 486
            |||::..|.|||:|.||.   |...:|.|:.|           |.|||||.|||..
Yeast   282 NLLISGDGTVKISDFGVS---LAASSTNSSDSSESLDELELAKTVGTPAFFAPEMCLGEDAFTRY 343

  Fly   487 -IPGQNEYCGRA----ADVWALGATLYSLIFGNVPFLADSVPLLYEKIKQDSVKFP-----ENHK 541
             :..:|.:.|..    .|:||:|.|||.|:||.:||.:|....|:|||..|.:|||     :::|
Yeast   344 NLTKENLFRGSCISFMIDIWAVGVTLYCLLFGMLPFFSDFELKLFEKIVNDPLKFPTFKEIQSNK 408

  Fly   542 VT--------ENLKSCIVQMLEKNPTQRITIPQLKTSKWVTSDGDYPLPTEEENCCL-------- 590
            |:        |..|..::::|||||.:|:|||.:|...:|:.|.|: :|..:|....
Yeast   409 VSKVSCEEEYEMAKDLLLKLLEKNPQKRMTIPAIKKHPFVSWDFDH-VPENDEKLLSSVLEQKLR 472

  Fly   591 -----------VQVDDEDI------------DSVVRSIPKLD 609
                       :.:...::            :||::|||..|
Yeast   473 FQCNQTDQFEPISISKHELKNAVSGVGKKIKESVLKSIPLKD 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17698	NP_001036633.2	S_TKc	283..573	CDD:214567	115/336 (34%)
CG17698	NP_001036633.2	STKc_CAMKK	288..574	CDD:271020	114/332 (34%)
SAK1	NP_011055.3	STKc_LKB1_CaMKK	139..448	CDD:270910	114/330 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001468
OrthoInspector	1	1.000	-	-		otm46933
orthoMCL	1	0.900	-	-		OOG6_100881
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1400
SonicParanoid	1	1.000	-	-		X1033
TreeFam	1	0.960	-	-
	9	8.800