DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17698 and MYLK2

DIOPT Version :9

Sequence 1:	NP_001036633.2	Gene:	CG17698 / 4379919	FlyBaseID:	FBgn0040056	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_149109.1	Gene:	MYLK2 / 85366	HGNCID:	16243	Length:	596	Species:	Homo sapiens

Alignment Length:	373	Identity:	78/373 - (20%)
Similarity:	151/373 - (40%)	Gaps:	80/373 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 EQIGQGSYGLVKLAYSEEDSTHYAMKILSKKRLLRQAGLMRRGPRKATSPLDR--VYREIAVLKK 349
            |.:|.|.:|.|.....:......|.|::.|:                 :|.|:  |..||.|:.:
Human   289 EALGGGKFGAVCTCMEKATGLKLAAKVIKKQ-----------------TPKDKEMVLLEIEVMNQ 336

  Fly   350 LDHPNVVKLVEVLDDPLEDSLYMVFELVKQGEVLRIPTDNPLSEKRAWSIFRESLLGLEYYTMLS 414
            |:|.|:::|...::.|.|..|:|  |.::.||:.                  |.::..:|:....
Human   337 LNHRNLIQLYAAIETPHEIVLFM--EYIEGGELF------------------ERIVDEDYHLTEV 381

  Fly   415 SSAISLKRIF--VYTVHHQKIIHADIKPGNLL-LTEFGH-VKIADLGVCNEFLGDDATISNGSTA 475
            .:.:.:::|.  :..:|..:::|.|:||.|:| :...|| |||.|.|:...:..::....|   .
Human   382 DTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVN---F 443

  Fly   476 GTPAFRAPETLIPGQNEYCGRAADVWALGATLYSLIFGNVPFLADSVPLLYEKIKQDSVKFPEN- 539
            |||.|.:||.:   ..:......|:|::|...|.|:.|..|||.|........:...:..|.|.
Human   444 GTPEFLSPEVV---NYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVLSGNWYFDEET 505

  Fly   540 -HKVTENLKSCIVQMLEKNPTQRITIPQLKTSKWVTSDGDYPLPTEEENCCLVQVDDEDIDSVVR 603
             ..|::..|..:..::.|:...|:...|.....|:.:     |..:.:.|
Human   506 FEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNN-----LAEKAKRC--------------- 550

  Fly   604 SIPKLDTLILIKTMLKKHSFGNPFVKGCSGTSSSLAGCSRIERFIRAG 651
             ..:|.:.||:|..|.|..:...|:        :::..:|.::...:|
Human   551 -NRRLKSQILLKKYLMKRRWKKNFI--------AVSAANRFKKISSSG 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17698	NP_001036633.2	S_TKc	283..573	CDD:214567	66/293 (23%)
CG17698	NP_001036633.2	STKc_CAMKK	288..574	CDD:271020	66/293 (23%)
MYLK2	NP_149109.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..224
		STKc_MLCK2	280..540	CDD:271092	66/293 (23%)
		Calmodulin-binding. /evidence=ECO:0000250	574..586		1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000