DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17698 and TOS3

DIOPT Version :9

Sequence 1:	NP_001036633.2	Gene:	CG17698 / 4379919	FlyBaseID:	FBgn0040056	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_011336.3	Gene:	TOS3 / 852696	SGDID:	S000003147	Length:	560	Species:	Saccharomyces cerevisiae

Alignment Length:	492	Identity:	132/492 - (26%)
Similarity:	217/492 - (44%)	Gaps:	120/492 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 PIYPNVPYSPYSTPFSSPRSSRRKPAFRESRRISI--DKSGSFLQLNQYRLMEQIGQGSYGLVKL 299
            |:.| :|.|......:|..|||    .:|:|::.:  :.......||.:.::..:|.|.||.|||
Yeast     7 PVQP-LPRSSLLYNNASNSSSR----IKETRKVKLLYNPLTKRQILNNFEILATLGNGQYGKVKL 66

  Fly   300 AYSEEDSTHYAMKILSKKRLLRQAGLMRRGPRKATSPLDRVYREIAVLKKLDHPNVVKLVEVLDD 364
            |.........|:|||:  |..:::|...:  .|..:|  ||.:||.|:|:..|.|||:|.|:|:|
Yeast    67 ARDLGTGALVAIKILN--RFEKRSGYSLQ--LKVENP--RVNQEIEVMKRCHHENVVELYEILND 125

  Fly   365 PLEDSLYMVFELVKQGEV-------LRIPTDNP--LSEKRAWSIFRESLLGLEYYTMLSSSAISL 420
            |....:|:|.|...:|.|       :.|....|  |:.:::..:..:.:.||||
Yeast   126 PESTKVYLVLEYCSRGPVKWCPENKMEIKAVGPSILTFQQSRKVVLDVVSGLEY----------- 179

  Fly   421 KRIFVYTVHHQKIIHADIKPGNLLLTEFGHVKIADLGVCNEFLGDDATISNGST----------- 474
                   :|.|.|.|.||||.|||::..|.|||:|.||.       .:.:.|||
Yeast   180 -------LHSQGITHRDIKPSNLLISSNGTVKISDFGVA-------MSTATGSTNIQSSHEQLLK 230

  Fly   475 ---AGTPAFRAPETLIPGQNEY-CGRAADVWALGATLYSLIFGNVPFLADSVPLLYEKIKQDSVK 535
               .|||||.||| |...:.|| |..|.|:|:||.|:|.|:||.:||.|:|...|::.|....::
Yeast   231 SRALGTPAFFAPE-LCSTEKEYSCSSAIDIWSLGVTIYCLLFGKLPFNANSGLELFDSIINKPLE 294

  Fly   536 FPENHKVTE------------NLKSCIVQMLEKNPTQRITIPQLKTSKWV----TSDGDYPLPTE 584
            ||...::..            :.|..:.::|:|:|.:||.:..:|...::    .||....|...
Yeast   295 FPSYEEMLNGATSGITMEEYTDAKDLLKKLLQKDPDKRIKLADIKVHPFMCHYGKSDAASVLTNL 359

  Fly   585 E----------ENCCLVQVDDEDIDSVVRSIPKLDTLIL-------IKTMLKKHSFGNPFVKGCS 632
            |          .:|..|::....::|   |...||::.:       ::|...::|..:|.:...:
Yeast   360 ETFHELKVSPPSSCKRVELVSLPVNS---SFASLDSVYMENFDHNNLRTGADRNSTYSPSIYDAN 421

  Fly   633 GTSSSLAGCSRIERFIRAGRSNSAPGSYHMSTARQPS 669
            ..|                     |.:||...:|:.|
Yeast   422 TLS---------------------PSAYHNIGSRESS 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17698	NP_001036633.2	S_TKc	283..573	CDD:214567	101/325 (31%)
CG17698	NP_001036633.2	STKc_CAMKK	288..574	CDD:271020	101/325 (31%)
TOS3	NP_011336.3	STKc_LKB1_CaMKK	56..344	CDD:270910	101/319 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2005
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001468
OrthoInspector	1	1.000	-	-		otm46933
orthoMCL	1	0.900	-	-		OOG6_100881
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1400
SonicParanoid	1	1.000	-	-		X1033
TreeFam	1	0.960	-	-
	9	8.650