DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17698 and Camkk2

DIOPT Version :9

Sequence 1:	NP_001036633.2	Gene:	CG17698 / 4379919	FlyBaseID:	FBgn0040056	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_112628.2	Gene:	Camkk2 / 83506	RGDID:	620092	Length:	587	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	222/452 - (49%)
Similarity:	291/452 - (64%)	Gaps:	50/452 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 EPPQHNTASKPQILYETRPIYPNVPYSPYSTPFSSPRSSRRKPAFRESRRISIDKSGSFLQLNQY 283
            |..|...||...:....|.|.|::.|||.|:|.||||..||...  ||..:||......:|||||
  Rat   102 ERSQGGPASNSSLDMNGRCICPSLSYSPASSPQSSPRMPRRPTV--ESHHVSITGLQDCVQLNQY 164

  Fly   284 RLMEQIGQGSYGLVKLAYSEEDSTHYAMKILSKKRLLRQAGLMRRGPRKAT-----------SPL 337
            .|.::||:||||:|||||:|.|:|:||||:||||:|:||||..||.|.:.|           .|:
  Rat   165 TLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPI 229

  Fly   338 DRVYREIAVLKKLDHPNVVKLVEVLDDPLEDSLYMVFELVKQGEVLRIPTDNPLSEKRAWSIFRE 402
            ::||:|||:|||||||||||||||||||.||.||||||||.||.|:.:||..||||.:|...|::
  Rat   230 EQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQD 294

  Fly   403 SLLGLEYYTMLSSSAISLKRIFVYTVHHQKIIHADIKPGNLLLTEFGHVKIADLGVCNEFLGDDA 467
            .:.|:||                  :|:|||||.||||.|||:.|.||:||||.||.|||.|.||
  Rat   295 LIKGIEY------------------LHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDA 341

  Fly   468 TISNGSTAGTPAFRAPETLIPGQNEYCGRAADVWALGATLYSLIFGNVPFLADSVPLLYEKIKQD 532
            .:||  |.|||||.|||:|...:..:.|:|.||||:|.|||..:||..||:.:.:..|:.|||..
  Rat   342 LLSN--TVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQ 404

  Fly   533 SVKFPENHKVTENLKSCIVQMLEKNPTQRITIPQLKTSKWVTSDGDYPLPTEEENCCLVQVDDED 597
            :::||:...:.|:||..|.:||:|||..||.:|::|...|||..|..|||:|:|||.||:|.:|:
  Rat   405 ALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEE 469

  Fly   598 IDSVVRSIPKLDTLILIKTMLKKHSFGNPFVKGCSGTSSSLAGCSRIERFIRAGRSNSAPGS 659
            :::.|:.||.|.|:||:|||::|.||||||           .|..|.|      ||.||||:
  Rat   470 VENSVKHIPSLATVILVKTMIRKRSFGNPF-----------EGSRREE------RSLSAPGN 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17698	NP_001036633.2	S_TKc	283..573	CDD:214567	155/300 (52%)
CG17698	NP_001036633.2	STKc_CAMKK	288..574	CDD:271020	154/296 (52%)
Camkk2	NP_112628.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..115		4/12 (33%)
		RP domain	203..225		7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..224		6/19 (32%)
		Autoinhibitory domain. /evidence=ECO:0000250	471..476		1/4 (25%)
		Calmodulin-binding. /evidence=ECO:0000250	474..499		15/24 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..587		13/36 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I3920
eggNOG	1	0.900	-	-		E1_KOG0585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	409	1.000	Inparanoid score	I1816
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D856506at2759
OrthoFinder	1	1.000	-	-		FOG0001468
OrthoInspector	1	1.000	-	-		otm46147
orthoMCL	1	0.900	-	-		OOG6_100881
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1033
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.770