DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17698 and STK11

DIOPT Version :9

Sequence 1:	NP_001036633.2	Gene:	CG17698 / 4379919	FlyBaseID:	FBgn0040056	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_000446.1	Gene:	STK11 / 6794	HGNCID:	11389	Length:	433	Species:	Homo sapiens

Alignment Length:	429	Identity:	125/429 - (29%)
Similarity:	195/429 - (45%)	Gaps:	107/429 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 LNQYRLMEQIGQGSYGLVKLAYSEEDSTHYAMKILSKKRLLRQAGLMRRGPRKATSPLDRVYREI 344
            :.:|.:.:.:|:||||.||.....|.....|:|||.||:|       ||.|....:    |.:||
Human    46 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKL-------RRIPNGEAN----VKKEI 99

  Fly   345 AVLKKLDHPNVVKLVEVLDDPLEDSLYMVFELVKQG--EVLRIPTDNPLSEKR-----AWSIFRE 402
            .:|::|.|.||::||:||.:..:..:|||.|....|  |:|     :.:.|||     |...|.:
Human   100 QLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEML-----DSVPEKRFPVCQAHGYFCQ 159

  Fly   403 SLLGLEYYTMLSSSAISLKRIFVYTVHHQKIIHADIKPGNLLLTEFGHVKIADLGVC---NEFLG 464
            .:.||||                  :|.|.|:|.||||||||||..|.:||:||||.   :.|..
Human   160 LIDGLEY------------------LHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAA 206

  Fly   465 DDATISNGSTAGTPAFRAPETLIPGQNEYCGRAADVWALGATLYSLIFGNVPFLADSVPLLYEKI 529
            ||..   .::.|:|||:.|| :..|.:.:.|...|:|:.|.|||::..|..||..|::..|:|.|
Human   207 DDTC---RTSQGSPAFQPPE-IANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENI 267

  Fly   530 KQDSVKFPEN--HKVTENLKSCIVQMLEKNPTQRITIPQLKTSKWV-----TSDGDYPLP----T 583
            .:.|...|.:  ..:::.||.    |||..|.:|.:|.|::...|.     .::...|:|    |
Human   268 GKGSYAIPGDCGPPLSDLLKG----MLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDT 328

  Fly   584 EEENCCLVQV----------DDEDI----DSVV----------------------RSIPK---LD 609
            ::....:..|          :|||:    |.::                      |.:||   ::
Human   329 KDRWRSMTVVPYLEDLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMN 393

  Fly   610 TLILIKTMLKKHSFG---NPFVKGCSGTSS--SLAGCSR 643
            .....:...|..:.|   ||..|.||.:|.  .|:.|.:
Human   394 GTEAAQLSTKSRAEGRAPNPARKACSASSKIRRLSACKQ 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17698	NP_001036633.2	S_TKc	283..573	CDD:214567	103/301 (34%)
CG17698	NP_001036633.2	STKc_CAMKK	288..574	CDD:271020	103/302 (34%)
STK11	NP_000446.1	Sufficient for interaction with SIRT1. /evidence=ECO:0000269\|PubMed:18687677	45..90		18/50 (36%)
		STKc_LKB1	55..309	CDD:271021	102/295 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..331		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..433		10/36 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D856506at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920