DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17698 and Camkk1

DIOPT Version :9

Sequence 1:	NP_001036633.2	Gene:	CG17698 / 4379919	FlyBaseID:	FBgn0040056	Length:	694	Species:	Drosophila melanogaster
Sequence 2:	NP_113850.1	Gene:	Camkk1 / 60341	RGDID:	62023	Length:	505	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	215/503 - (42%)
Similarity:	295/503 - (58%)	Gaps:	85/503 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 ESVKRYPCKVSN--EPPQH--------NTASKPQILYETRPIYPNV------------------P 243
            |..:..|...||  :||..        .:||:|      .|:.|::                  .
  Rat    29 EEAEEGPEPASNGVDPPPRARAASVIPGSASRP------TPVRPSLSARKFSLQERPAGSCLEAQ 87

  Fly   244 YSPYST-PFS--SPRSSRRKPAFRESRRISIDKSGSFLQLNQYRLMEQIGQGSYGLVKLAYSEED 305
            ..|||| |.|  |||:.|| |.. ||..::|..:...:|||||:|..:||:|:||:|:|||:|.:
  Rat    88 VGPYSTGPASHMSPRAWRR-PTI-ESHHVAISDTEDCVQLNQYKLQSEIGKGAYGVVRLAYNERE 150

  Fly   306 STHYAMKILSKKRLLRQAGLMRR-----------GPRKATSPLDRVYREIAVLKKLDHPNVVKLV 359
            ..|||||:||||:||:|.|..||           ||.|...||:|||:|||:||||||.|||||:
  Rat   151 DRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAPQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLI 215

  Fly   360 EVLDDPLEDSLYMVFELVKQGEVLRIPTDNPLSEKRAWSIFRESLLGLEYYTMLSSSAISLKRIF 424
            ||||||.||:||:||:|:::|.|:.:|.|.|..|::|....|:.:|||||
  Rat   216 EVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEY--------------- 265

  Fly   425 VYTVHHQKIIHADIKPGNLLLTEFGHVKIADLGVCNEFLGDDATISNGSTAGTPAFRAPETLIPG 489
               :|.|||:|.||||.||||.:.|||||||.||.|:|.|:||.:|  ||||||||.|||.:...
  Rat   266 ---LHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLS--STAGTPAFMAPEAISDT 325

  Fly   490 QNEYCGRAADVWALGATLYSLIFGNVPFLADSVPLLYEKIKQDSVKFPENHKVTENLKSCIVQML 554
            ...:.|:|.||||.|.|||..::|..||:.:.:..|:.|||.::|.|||..:|:|.||..|::||
  Rat   326 GQSFSGKALDVWATGVTLYCFVYGKCPFIDEYILALHRKIKNEAVVFPEEPEVSEELKDLILKML 390

  Fly   555 EKNPTQRITIPQLKTSKWVTSDGDYPLPTEEENCCLVQVDDEDIDSVVRSIPKLDTLILIKTMLK 619
            :|||..||.:..:|...|||..|:.|||:|||:|.:|:|.:|::.:.|:.||...|:||:|:||:
  Rat   391 DKNPETRIGVSDIKLHPWVTKHGEEPLPSEEEHCSVVEVTEEEVKNSVKLIPSWTTVILVKSMLR 455

  Fly   620 KHSFGNPFVKGCSGTSSSLA---------GCSRIERFIRAGRSNSAPG 658
            |.||||||.........|::         ||.      ..|:|...||
  Rat   456 KRSFGNPFEPQARREERSMSAPGNLLLKEGCG------EGGKSPELPG 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17698	NP_001036633.2	S_TKc	283..573	CDD:214567	148/300 (49%)
CG17698	NP_001036633.2	STKc_CAMKK	288..574	CDD:271020	147/296 (50%)
Camkk1	NP_113850.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..66		10/42 (24%)
		PKc_like	127..410	CDD:304357	150/302 (50%)
		S_TKc	128..409	CDD:214567	148/300 (49%)
		RP domain. /evidence=ECO:0000269\|PubMed:10336483	167..189		6/21 (29%)
		Autoinhibitory domain. /evidence=ECO:0000269\|PubMed:10336483, ECO:0000269\|PubMed:9335539	435..440		1/4 (25%)
		Calmodulin-binding. /evidence=ECO:0000269\|PubMed:10467092, ECO:0000269\|PubMed:9335539	438..463		14/24 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..505		11/44 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334435
Domainoid	1	1.000	161	1.000	Domainoid score	I3920
eggNOG	1	0.900	-	-		E1_KOG0585
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H10327
Inparanoid	1	1.050	409	1.000	Inparanoid score	I1816
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001468
OrthoInspector	1	1.000	-	-		otm46147
orthoMCL	1	0.900	-	-		OOG6_100881
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1033
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.650