Protein Alignment Mkp and DUSP4

DIOPT Version :10

• Sequence 1: NP_001036572.1
• Gene: Mkp / 4379907
• FlyBaseID: FBgn0083992
• Length: 203
• Species: Drosophila melanogaster
• Sequence 2: NP_001385.1
• Gene: DUSP4 / 1846
• HGNCID: 3070
• Length: 394
• Species: Homo sapiens
• Alignment Length: 240
• Identity: 67/240 - (27%)
• Similarity: 105/240 - (43%)
• Gaps: 50/240 - (20%)

  Fly     6 ELQRRMGNLRPTATVV---TTPTGVRYIERSTSSVCVEDIAHCSQQLD-----------PREY-G 55
            |::.|:.:...:|.:|   .:|......|.||.|:.|:.:...:::.|           ..|| .
Human    92 EVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPE 156

  Fly    56 FVVDTK-----PDSVP------------AC------------ILSDFLYLGS-QDAVSADNIIKY 90
            |...||     |..||            :|            || .|||||| ..|...|.:...
Human   157 FCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEIL-PFLYLGSAYHAARRDMLDAL 220

  Fly    91 KITHILSVGIQTP-EVEWPLPVNCTFLPCLDLPETNLMNYILPASMEFIEDAHRSQGCVLVHCNA 154
            .||.:|:|....| ..|......|  :|..|..:.::.::.:.| :|:|:.....:|.|||||.|
Human   221 GITALLNVSSDCPNHFEGHYQYKC--IPVEDNHKADISSWFMEA-IEYIDAVKDCRGRVLVHCQA 282

  Fly   155 GVSRSPSVVIGYLMQRRDMCYEDAYNLVKSWRPCIQPNAGFIQQL 199
            |:|||.::.:.|||.::.:..|:|:..||..|..|.||..|:.||
Human   283 GISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQL 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mkp	NP_001036572.1	DSP	66..201	CDD:350348	49/160 (31%)
DUSP4	NP_001385.1	DSP_MapKP	9..158	CDD:238723	13/65 (20%)
		DSP_DUSP4	196..336	CDD:350488	47/136 (35%)