DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ephrin and Efnb3

DIOPT Version :9

Sequence 1:	NP_651927.1	Gene:	Ephrin / 43799	FlyBaseID:	FBgn0040324	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001094450.2	Gene:	Efnb3 / 360546	RGDID:	2541	Length:	340	Species:	Rattus norvegicus

Alignment Length:	447	Identity:	96/447 - (21%)
Similarity:	146/447 - (32%)	Gaps:	174/447 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 PKFG----------ATSFVTLLTLICMETVLLSTMSSCAKTFYMHWNTSNSIFRIDNTDHIIDVN 240
            |.||          ...|..|::.:.:|.|              :||::|..|:.:. .:::...
  Rat     4 PHFGPGGVQVGALLLLGFAGLVSGLSLEPV--------------YWNSANKRFQAEG-GYVLYPQ 53

  Fly   241 KGNLAFEFDQVHIICP-VYEPGTFENET-EKYIIYNVSKVEYETCRITNADPRVIAICDKPQKLM 303
            .|      |::.::|| ...||...:.: |.|.:|.|...:...|....| |.::..||:|...:
  Rat    54 IG------DRLDLLCPRARPPGPHSSPSYEFYKLYLVGGAQGRRCEAPPA-PNLLLTCDRPDLDL 111

  Fly   304 FFTITFRPFTPQPGGLEFLPGNDYYFISTS--SKDDLYRRIGGRCSTNNMKVVFKVCCAPEDNNK 366
            .|||.|:.::|...|.||...:|||.|:||  :::.|....||.|.|..|||:.:|
  Rat   112 RFTIKFQEYSPNLWGHEFRSHHDYYIIATSDGTREGLESLQGGVCLTRGMKVLLRV--------- 167

  Fly   367 TTALSNSKSVTDTGGAINVNIANNDESHVNSHGNNIAIGTNIGINGGQIIGGPQSAGIPINPLS- 430
                                                          ||   .|:...:|..|:|
  Rat   168 ----------------------------------------------GQ---SPRGGAVPRKPVSE 183

  Fly   431 ---------------GNNNINGIPTTINSNIDQFNR-----IPIQPNIIGNHVGTNAVGTGIVGG 475
                           |.::|.|.|   |||......     .|..|.:.|...|...:..|:.|.
  Rat   184 MPMERDRGAAHSQEPGKDSIPGDP---NSNATSRGAEGPLPPPSMPAVAGAAGGLALLLLGVAGA 245

  Fly   476 GGIIL--------------TPGHAHGNINMLQPGRGGING---AYPGHHHIQTGIRINNVPTQHN 523
            ||.:.              .|| :.|....|..|.||..|   |.||    :.||.:..
  Rat   246 GGAMCWRRRRAKPSESRHPGPG-SFGRGGSLGLGGGGGMGPREAEPG----ELGIALRG------ 299

  Fly   524 YPSHKGNANSNINGNDDH---HHYNK------HPNEVVKNEELTYNSGAATSDGNIF 571
                        .|..|.   .||.|      ||..:|::       |...|..||:
  Rat   300 ------------GGAADPPFCPHYEKVSGDYGHPVYIVQD-------GPPQSPPNIY 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	42/144 (29%)
Ephrin	NP_651927.1	PigN	<557..>622	CDD:282796	4/15 (27%)
Efnb3	NP_001094450.2	Cupredoxin	29..168	CDD:302766	45/215 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346768
Domainoid	1	1.000	77	1.000	Domainoid score	I8639
eggNOG	1	0.900	-	-		E1_KOG3858
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001210
OrthoInspector	1	1.000	-	-		otm44780
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11304
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.840