DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ephrin and Efnb2

DIOPT Version :9

Sequence 1:	NP_651927.1	Gene:	Ephrin / 43799	FlyBaseID:	FBgn0040324	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001100798.1	Gene:	Efnb2 / 306636	RGDID:	1309497	Length:	336	Species:	Rattus norvegicus

Alignment Length:	290	Identity:	78/290 - (26%)
Similarity:	119/290 - (41%)	Gaps:	58/290 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 LLTLICMETVLLSTMSSCAKTFYMHWNTSNSIFRIDNTDHIIDVNKGNLAFEFDQVHIICPVYEP 260
            ||.::|...:..|.:..     .::||:|||.| :.....::....|      |::.||||..:.
  Rat    18 LLMVLCRTAISRSIVLE-----PIYWNSSNSKF-LPGQGLVLYPQIG------DKLDIICPKVDS 70

  Fly   261 GTFENETEKYIIYNVSKVEYETCRITNADPRVIAICDKPQKLMFFTITFRPFTPQPGGLEFLPGN 325
            .|. .:.|.|.:|.|.|.:.:.|.|...:..::. |.:|.:.:.|||.|:.|:|...||||....
  Rat    71 KTV-GQYEYYKVYMVDKEQADRCTIKKENTPLLN-CARPDQDVKFTIKFQEFSPNLWGLEFQKNK 133

  Fly   326 DYYFISTS--SKDDLYRRIGGRCSTNNMKVVFKV-----CCAPEDNNKTT------ALSNSKSVT 377
            |||.||||  |.:.|..:.||.|.|..||::.||     ......||..|      |.:|.:|.|
  Rat   134 DYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSTRNNDPTRRPELEAGTNGRSST 198

  Fly   378 DTGGAINVNIANNDESHVNSHGNNIAIGTNI----GINGGQII---------------------G 417
             |...:..|..::.:.:...|..|..:|:.:    ||..|.||                     .
  Rat   199 -TSPFVKPNPGSSTDGNSAGHSGNNLLGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKH 262

  Fly   418 GPQ-----SAGIPINPLSGNNNINGIPTTI 442
            .||     |......|..|.||....|:.:
  Rat   263 SPQHTTTLSLSTLATPKRGGNNNGSEPSDV 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	49/147 (33%)
Ephrin	NP_651927.1	PigN	<557..>622	CDD:282796
Efnb2	NP_001100798.1	Ephrin-B_Ectodomain	32..168	CDD:259897	48/149 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346769
Domainoid	1	1.000	77	1.000	Domainoid score	I8639
eggNOG	1	0.900	-	-		E1_KOG3858
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001210
OrthoInspector	1	1.000	-	-		otm44780
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11304
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.840