DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ephrin and efnb2a

DIOPT Version :9

Sequence 1:	NP_651927.1	Gene:	Ephrin / 43799	FlyBaseID:	FBgn0040324	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_571098.1	Gene:	efnb2a / 30219	ZFINID:	ZDB-GENE-990415-67	Length:	332	Species:	Danio rerio

Alignment Length:	203	Identity:	60/203 - (29%)
Similarity:	102/203 - (50%)	Gaps:	20/203 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 MHWNTSNSIFRIDNTDHIIDVNKGNLAFEFDQVHIICPVYEPGTFENETEKYIIYNVSKVEYETC 283
            ::|||:|:.| :.....::....|      |::.|:||..|.|:.|. .|.|.:|.|...:.::|
Zfish    30 IYWNTTNTKF-VPGQGLVLYPQIG------DKMDIVCPRVEGGSMEG-VEYYKLYMVPLEQLKSC 86

  Fly   284 RITNADPRVIAICDKPQKLMFFTITFRPFTPQPGGLEFLPGNDYYFISTS--SKDDLYRRIGGRC 346
            ::|.||..::. |.||.:.:.||:.|:.|:|...||||..|.|||.||||  :.:.|..:.||.|
Zfish    87 QVTKADTPLLN-CVKPDQDVKFTLKFQEFSPNLWGLEFFRGKDYYIISTSNGTMEGLDNQEGGVC 150

  Fly   347 STNNMKVVFKVCCAPED--NNKTTALSNSKSVTDTGG-------AINVNIANNDESHVNSHGNNI 402
            .|.:||::.||...|.|  :.|....|......|.||       .:..:.:.:.|...:.:.::.
Zfish   151 KTKSMKIIMKVGQNPSDPISPKDYPTSYPPKHPDLGGKDSKSNEVLKPDASPHGEDKGDGNKSSS 215

  Fly   403 AIGTNIGI 410
            .||:.:.:
Zfish   216 VIGSEVAL 223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	49/140 (35%)
Ephrin	NP_651927.1	PigN	<557..>622	CDD:282796
efnb2a	NP_571098.1	Ephrin-B_Ectodomain	26..162	CDD:259897	49/140 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..212		8/49 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..285
		PDZ-binding. /evidence=ECO:0000255	330..332
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588213
Domainoid	1	1.000	87	1.000	Domainoid score	I7950
eggNOG	1	0.900	-	-		E1_KOG3858
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001210
OrthoInspector	1	1.000	-	-		otm25392
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11304
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4391
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.870