Protein Alignment Ephrin and Efnb1

DIOPT Version :10

• Sequence 1: NP_651927.1
• Gene: Ephrin / 43799
• FlyBaseID: FBgn0040324
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_058785.2
• Gene: Efnb1 / 25186
• RGDID: 2540
• Length: 345
• Species: Rattus norvegicus
• Alignment Length: 285
• Identity: 81/285 - (28%)
• Similarity: 117/285 - (41%)
• Gaps: 57/285 - (20%)

  Fly   194 VTLLTLICMETVLLSTMSSCAKTFYMHWNTSNSIFRIDNTDHIIDVNKGNLAFEFDQVHIICPVY 258
            :.:|||..:.|.|...:..      :.|::.|..| :.....:|....|      |::.||||..
  Rat    16 MVVLTLCRLATPLAKNLEP------VSWSSLNPKF-LSGKGLVIYPKIG------DKLDIICPRA 67

  Fly   259 EPGTFENETEKYIIYNVSKVEYETCRITNADPRVIAICDKPQKLMFFTITFRPFTPQPGGLEFLP 323
            |.|   ...|.|.:|.|...:...|. |..||.|:..|:|||:.:.|||.|:.|:|...||||..
  Rat    68 EAG---RPYEYYKLYLVRPEQAAACS-TVLDPNVLVTCNKPQQEIRFTIKFQEFSPNYMGLEFKK 128

  Fly   324 GNDYYFISTS--SKDDLYRRIGGRCSTNNMKVVFKVCCAPEDNNKTT--ALSNSKSVTDTGGAI- 383
            .:|||..|||  |.:.|..|.||.|.|..||:|.||   .:|.|..|  .|:.|:...::...:
  Rat   129 YHDYYITSTSNGSLEGLENREGGVCRTRTMKIVMKV---GQDPNAVTPEQLTTSRPSKESDNTVK 190

  Fly   384 NVNIANNDESHVNSHGNNIAIGTNIGINGGQIIGGPQSAGIPINPLSGNNNINGIPTTINSNIDQ 448
            ....|....|..:|.|.:..:..       |...||.:.|      ||:.:.:..   .||.:..
  Rat   191 TATQAPGRGSQGDSDGKHETVNQ-------QEKSGPGAGG------SGSGDTDSF---FNSKVAL 239

  Fly   449 FNRIPIQPNIIGNHVGTNAVGTGIV 473
            |                .|||.|.|
  Rat   240 F----------------AAVGAGCV 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	52/142 (37%)
Efnb1	NP_058785.2	Ephrin-B_Ectodomain	31..165	CDD:259897	53/153 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..227		14/70 (20%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:P98172	259..272
		Interaction with ZHX2. /evidence=ECO:0000250|UniProtKB:P98172	262..293
		PDZ-binding. /evidence=ECO:0000255	343..345