DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ephrin and EFNB3

DIOPT Version :9

Sequence 1:	NP_651927.1	Gene:	Ephrin / 43799	FlyBaseID:	FBgn0040324	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001397.1	Gene:	EFNB3 / 1949	HGNCID:	3228	Length:	340	Species:	Homo sapiens

Alignment Length:	384	Identity:	88/384 - (22%)
Similarity:	138/384 - (35%)	Gaps:	110/384 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 MHWNTSNSIFRIDNTDHIIDVNKGNLAFEFDQVHIICP-VYEPGTFENET-EKYIIYNVSKVEYE 281
            ::||::|..|:.:. .:::....|      |::.::|| ...||...:.. |.|.:|.|...:..
Human    33 VYWNSANKRFQAEG-GYVLYPQIG------DRLDLLCPRARPPGPHSSPNYEFYKLYLVGGAQGR 90

  Fly   282 TCRITNADPRVIAICDKPQKLMFFTITFRPFTPQPGGLEFLPGNDYYFISTS--SKDDLYRRIGG 344
            .|....| |.::..||:|...:.|||.|:.::|...|.||...:|||.|:||  :::.|....||
Human    91 RCEAPPA-PNLLLTCDRPDLDLRFTIKFQEYSPNLWGHEFRSHHDYYIIATSDGTREGLESLQGG 154

  Fly   345 RCSTNNMKVVFKVCCAPEDNN-KTTALSNSKSVTDTGGAINVNIANNDESHVNSHGNNIAIGTNI 408
            .|.|..|||:.:|..:|.... ....:|......|.|.|.::     :....|..|:..:..|:.
Human   155 VCLTRGMKVLLRVGQSPRGGAVPRKPVSEMPMERDRGAAHSL-----EPGKENLPGDPTSNATSR 214

  Fly   409 GINGGQIIGGPQSAGIPINPLSGNNNINGIPTTINSNIDQFNRIPIQPNIIGNHVGTNAVGTGIV 473
            |..|            |:.|                        |..|.:.|...|...:..|:.
Human   215 GAEG------------PLPP------------------------PSMPAVAGAAGGLALLLLGVA 243

  Fly   474 GGGGIIL--------------TPGHAHGNINMLQPGRGGING---AYPGHHHIQTGIRINNVPTQ 521
            |.||.:.              .|| :.|....|..|.||..|   |.||    :.||.:..
Human   244 GAGGAMCWRRRRAKPSESRHPGPG-SFGRGGSLGLGGGGGMGPREAEPG----ELGIALRG---- 299

  Fly   522 HNYPSHKGNANSNINGNDDH---HHYNK------HPNEVVKNEELTYNSGAATSDGNIF 571
                          .|..|.   .||.|      ||..:|::       |...|..||:
Human   300 --------------GGAADPPFCPHYEKVSGDYGHPVYIVQD-------GPPQSPPNIY 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	42/142 (30%)
Ephrin	NP_651927.1	PigN	<557..>622	CDD:282796	4/15 (27%)
EFNB3	NP_001397.1	Cupredoxin	31..168	CDD:327505	42/142 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..225		13/97 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..298		13/48 (27%)
		PDZ-binding. /evidence=ECO:0000255	338..340		88/384 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153155
Domainoid	1	1.000	74	1.000	Domainoid score	I9142
eggNOG	1	0.900	-	-		E1_KOG3858
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001210
OrthoInspector	1	1.000	-	-		otm40642
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11304
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4391
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.870