DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ephrin and EFNB2

DIOPT Version :9

Sequence 1:	NP_651927.1	Gene:	Ephrin / 43799	FlyBaseID:	FBgn0040324	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_016875895.1	Gene:	EFNB2 / 1948	HGNCID:	3227	Length:	335	Species:	Homo sapiens

Alignment Length:	230	Identity:	68/230 - (29%)
Similarity:	100/230 - (43%)	Gaps:	47/230 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 DQVHIICPVYEPGTFENETEKYIIYNVSKVEYETCRITNADPRVIAICDKPQKLMFFTITFRPFT 313
            |::.||||..:..|. .:.|.|.:|.|.|.:.:.|.|...:..::. |.||.:.:.|||.|:.|:
Human    58 DKLDIICPKVDSKTV-GQYEYYKVYMVDKDQADRCTIKKENTPLLN-CAKPDQDIKFTIKFQEFS 120

  Fly   314 PQPGGLEFLPGNDYYFISTS--SKDDLYRRIGGRCSTNNMKVVFKV----CCAPEDNNK------ 366
            |...||||....|||.||||  |.:.|..:.||.|.|..||::.||    ..|....||
Human   121 PNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSTRNKDPTRRP 185

  Fly   367 -TTALSNSKSVTDTGGAINVNIANNDESHVNSHGNNIAIGTNI----GINGGQII---------- 416
             ..|.:|.:|.| |...:..|..::.:.:...|..|..:|:.:    ||..|.||
Human   186 ELEAGTNGRSST-TSPFVKPNPGSSTDGNSAGHSGNNILGSEVALFAGIASGCIIFIVIIITLVV 249

  Fly   417 -----------GGPQ-SAGIPINPL-----SGNNN 434
                       ..|| :..:.::.|     |||||
Human   250 LLLKYRRRHRKHSPQHTTTLSLSTLATPKRSGNNN 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	43/114 (38%)
Ephrin	NP_651927.1	PigN	<557..>622	CDD:282796
EFNB2	XP_016875895.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153156
Domainoid	1	1.000	74	1.000	Domainoid score	I9142
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001210
OrthoInspector	1	1.000	-	-		otm40642
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11304
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4391
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.970