Protein Alignment Ephrin and EFNB1

DIOPT Version :10

• Sequence 1: NP_651927.1
• Gene: Ephrin / 43799
• FlyBaseID: FBgn0040324
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_004420.1
• Gene: EFNB1 / 1947
• HGNCID: 3226
• Length: 346
• Species: Homo sapiens
• Alignment Length: 192
• Identity: 60/192 - (31%)
• Similarity: 89/192 - (46%)
• Gaps: 34/192 - (17%)

  Fly   249 DQVHIICPVYEPGTFENETEKYIIYNVSKVEYETCRITNADPRVIAICDKPQKLMFFTITFRPFT 313
            |::.||||..|.|   ...|.|.:|.|...:...|. |..||.|:..|::|::.:.|||.|:.|:
Human    58 DKLDIICPRAEAG---RPYEYYKLYLVRPEQAAACS-TVLDPNVLVTCNRPEQEIRFTIKFQEFS 118

  Fly   314 PQPGGLEFLPGNDYYFISTS--SKDDLYRRIGGRCSTNNMKVVFKVCCAPEDNNKTT--ALSNSK 374
            |...||||...:|||..|||  |.:.|..|.||.|.|..||::.||   .:|.|..|  .|:.|:
Human   119 PNYMGLEFKKHHDYYITSTSNGSLEGLENREGGVCRTRTMKIIMKV---GQDPNAVTPEQLTTSR 180

  Fly   375 SVTDTGGAINV---------NIANNDESH--VNSHGNNIAIGTNIGINGGQIIGGPQSAGIP 425
            ...:....:.:         ::.::|..|  ||....     :..|.:||       |:|.|
Human   181 PSKEADNTVKMATQAPGSRGSLGDSDGKHETVNQEEK-----SGPGASGG-------SSGDP 230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	44/110 (40%)
EFNB1	NP_004420.1	Ephrin-B_Ectodomain	31..165	CDD:259897	45/113 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..228		12/70 (17%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:16930449	260..273
		Interaction with ZHX2. /evidence=ECO:0000250|UniProtKB:P52795	263..294
		PDZ-binding. /evidence=ECO:0000255	344..346