DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ephrin and efn-3

DIOPT Version :9

Sequence 1:	NP_651927.1	Gene:	Ephrin / 43799	FlyBaseID:	FBgn0040324	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_510250.3	Gene:	efn-3 / 184508	WormBaseID:	WBGene00001164	Length:	211	Species:	Caenorhabditis elegans

Alignment Length:	240	Identity:	58/240 - (24%)
Similarity:	93/240 - (38%)	Gaps:	56/240 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 VLLSTMSSCAKTFYMHWNTSNSIFRIDNTDHIIDVNKGNLAFEFDQVHIICPVYEPGTFENETEK 269
            :.::.:.||.....:.||:.........|...:|:.        ||:.||||.....|:|...
Worm    11 LFVAPLVSCRNYHDVMWNSKQFPVAFKTTPIKVDLG--------DQLTIICPKAYGMTYEYAK-- 65

  Fly   270 YIIYNVSKVEYETCRITNADPRVIAICDKPQKLMFFTITFRPFTPQPGGLEFLPGNDYYFISTSS 334
              :|.|.:.|:..|.:  .:|..:.:|..........:.||...|.|.|::|..|..||.||||:
Worm    66 --LYWVGETEWSQCWL--HEPVWLGVCATENYTTEVKLIFRQTNPIPDGMDFQVGKTYYIISTST 126

  Fly   335 KD--DLYRRIGGRCSTNNMKVVFKVCCAPEDNNKTTALSNSKS-VTDTGGAINVNIANNDESHVN 396
            .|  .:.:.:||.|..::||:...|....:.       |:||| :|:...|
Worm   127 GDIEGINQAVGGLCKYHHMKLAISVVGYEKQ-------SHSKSEITEKNFA-------------- 170

  Fly   397 SHGNNIAIGTNIGINGGQIIGGPQSAGIPINPLSGNNNINGIPTT 441
             ||    ||..|. ..||::.            ||:.|...:.||
Worm   171 -HG----IGYEIH-EVGQLVS------------SGHQNFTLLTTT 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	37/142 (26%)
Ephrin	NP_651927.1	PigN	<557..>622	CDD:282796
efn-3	NP_510250.3	Ephrin_ectodomain	22..151	CDD:259861	37/142 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3858
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001210
OrthoInspector	1	1.000	-	-		otm14114
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11304
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4391
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940