DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ephrin and Efna3

DIOPT Version :9

Sequence 1:	NP_651927.1	Gene:	Ephrin / 43799	FlyBaseID:	FBgn0040324	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_574979.4	Gene:	Efna3 / 170901	RGDID:	620390	Length:	230	Species:	Rattus norvegicus

Alignment Length:	218	Identity:	53/218 - (24%)
Similarity:	85/218 - (38%)	Gaps:	54/218 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 LLTLICMETVLLSTMS-----SCAKTFYMHWNTSNSIFRIDNTDHIIDVNKGNLAFEFDQVHIIC 255
            ||.|:.:...||..::     :......::||:||...|.:.....::||        |.:.|.|
  Rat     7 LLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVN--------DYLDIYC 63

  Fly   256 PVYEPGTFENETEKYIIYNVSKVEYETCRITNADPR-----------VIAICDKPQKLMFFTITF 309
            |.|.........|:|::|.|:...|.||..:....|           .|...:|.|:...|::
  Rat    64 PHYNSSGPGGGAEQYVLYMVNLSGYRTCNASQGSKRWECNRQHASHSPIKFSEKFQRYSAFSL-- 126

  Fly   310 RPFTPQPGGLEFLPGNDYYFISTSSKDDLYRRIGGRCSTNNMKVVFKVCCAPEDNNKTTALSNSK 374
                    |.||..|.:||:|||.:     ..:..:|.  .|||.  ||||      :|:.|..|
  Rat   127 --------GYEFHAGQEYYYISTPT-----HNLHWKCL--RMKVF--VCCA------STSHSGEK 168

  Fly   375 SVT-----DTGGAINVNIANNDE 392
            .|.     ..|..:.:|:..:.|
  Rat   169 PVPTLPQFTMGPNVKINVLEDFE 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	37/151 (25%)
Ephrin	NP_651927.1	PigN	<557..>622	CDD:282796
Efna3	XP_574979.4	Ephrin-A_Ectodomain	31..158	CDD:259896	37/153 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346771
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11304
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940