DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ephrin and Efna5

DIOPT Version :9

Sequence 1:	NP_651927.1	Gene:	Ephrin / 43799	FlyBaseID:	FBgn0040324	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_446355.1	Gene:	Efna5 / 116683	RGDID:	620391	Length:	228	Species:	Rattus norvegicus

Alignment Length:	225	Identity:	63/225 - (28%)
Similarity:	98/225 - (43%)	Gaps:	41/225 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 VTLLTLICMETVLLSTMSS--CAKTFYMHWNTSNSIFRIDNTDHIIDV--NKGNLAFEFDQVHII 254
            :|||.|:....|......|  .|..:.::||:||.  |....|:.|||  |        |.:.:.
  Rat     7 LTLLFLVLWMCVFSQDPGSKVVADRYAVYWNSSNP--RFQRGDYHIDVCIN--------DYLDVF 61

  Fly   255 CPVYEPGTFENETEKYIIYNVSKVEYETCRITNADPRVIAICDKPQK---LMFFTITFRPFTPQP 316
            ||.||....|::||:|::|.|:...|..|..|:...:... |::|..   .:.|:..|:.|||..
  Rat    62 CPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWE-CNRPHSPNGPLKFSEKFQLFTPFS 125

  Fly   317 GGLEFLPGNDYYFISTSSKDDLYRRIGGRCSTNNMKVVFKVCCAPEDNNKTTALSNSKSVTDTGG 381
            .|.||.||.:|::||::..|:      ||.|...:||..:         .|.:...:..|.|...
  Rat   126 LGFEFRPGREYFYISSAIPDN------GRRSCLKLKVFVR---------PTNSCMKTIGVRDRVF 175

  Fly   382 AINVNIANN--------DESHVNSHGNNIA 403
            .:|..:.|:        .||...|.|.|.|
  Rat   176 DVNDKVENSLEPADDTVHESAEPSRGENAA 205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	45/145 (31%)
Ephrin	NP_651927.1	PigN	<557..>622	CDD:282796
Efna5	NP_446355.1	Ephrin-A_Ectodomain	30..159	CDD:259896	45/145 (31%)
Efna5	NP_446355.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..205		5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11304
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010