DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ephrin and efnb1

DIOPT Version :9

Sequence 1:	NP_651927.1	Gene:	Ephrin / 43799	FlyBaseID:	FBgn0040324	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	XP_002934941.1	Gene:	efnb1 / 100494328	XenbaseID:	XB-GENE-1011783	Length:	328	Species:	Xenopus tropicalis

Alignment Length:	377	Identity:	98/377 - (25%)
Similarity:	138/377 - (36%)	Gaps:	97/377 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 LLTLICMETVLLSTMSSCAKTFY-MHWNTSNSIFRIDNTDHIIDVNKGNLAFE--FDQVHIICPV 257
            |..|:.:..||....|:..|... :.|::.|..|.         ..||.:.:.  .|::.||||.
Frog     4 LRQLLGLLLVLYRLCSALGKNLEPVTWHSQNPRFL---------SGKGLVLYPEIGDRLDIICPK 59

  Fly   258 YEPGTFENETEKYIIYNVSKVEYETCRITNADPRVIAICDKPQKLMFFTITFRPFTPQPGGLEFL 322
            .:|   ....|.|.:|.|.:.:.|:|. |..||.|:..|::|.|...|||.|:.|:|...||||.
Frog    60 GDP---SQPYEYYKLYMVRRDQLESCS-TVMDPNVLVTCNQPGKEYRFTIKFQEFSPNYMGLEFR 120

  Fly   323 PGNDYYFISTS--SKDDLYRRIGGRCSTNNMKVVFKV-----CCAPEDNNKTTALSNSKSVTDTG 380
            ...||:..|||  :...|..|.||.|.|.:||::.||     ..|||   :.|....||...:||
Frog   121 RNVDYFITSTSNGTLQGLENREGGVCQTRSMKIIMKVGQDPNSVAPE---QLTTTRPSKEADNTG 182

  Fly   381 GAINVNIANNDESHVNSHGNNIAIGTNIGINGGQIIGGPQSAGIPINPLSGNNNINGIPTTINSN 445
            ........|..|:|                       |.........|.||    .|:....||.
Frog   183 KIATFGPWNGAENH-----------------------GKPDTNQSDKPTSG----GGVDGFFNSK 220

  Fly   446 IDQFNRIPIQPNIIGNHVGTNAVGTGIVGGGGIIL----------------TPGHAHG-NINML- 492
            |..|                .|:|.|.|....||:                |...|.| :::.|
Frog   221 IAVF----------------AAIGAGCVIFILIIIFLVVLLIKIRKRHRKHTQQRAPGLSLSTLA 269

  Fly   493 QPGRGGINGAYPGHHHIQTGIRINNVPTQHNYPSHKGNANSNINGNDDHHHY 544
            .|...|..|..|      :.|.|....|::||..|    ...::|:..|..|
Frog   270 SPKCSGNAGTEP------SDIIIPLRTTENNYCPH----YEKVSGDYGHPVY 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	49/150 (33%)
Ephrin	NP_651927.1	PigN	<557..>622	CDD:282796
efnb1	XP_002934941.1	Ephrin-B_Ectodomain	24..158	CDD:259897	48/146 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9055
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001210
OrthoInspector	1	1.000	-	-		otm47820
Panther	1	1.100	-	-	O	PTHR11304
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4391
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.040