DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ephrin and efnb2

DIOPT Version :9

Sequence 1:	NP_651927.1	Gene:	Ephrin / 43799	FlyBaseID:	FBgn0040324	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001093709.1	Gene:	efnb2 / 100101723	XenbaseID:	XB-GENE-488606	Length:	329	Species:	Xenopus tropicalis

Alignment Length:	282	Identity:	82/282 - (29%)
Similarity:	122/282 - (43%)	Gaps:	65/282 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 ICMETVLLSTMSSCAKTF-YMHWNTSNSIFRIDNTDHIIDVNKGNLAFEFDQVHIICPVYEPGTF 263
            :|:  :||.|..|.:... .::||:||:.| :.....|:....|      |::.||||..:..:
Frog    15 VCI--LLLRTAISWSTVLDPIYWNSSNARF-LPGQGLILYPKIG------DKLDIICPKVDSKS- 69

  Fly   264 ENETEKYIIYNVSKVEYETCRITNADPRVIAICDKPQKLMFFTITFRPFTPQPGGLEFLPGNDYY 328
            .::.|.|.||.|.|.:.::|.|.:..|  :..|.||.:.:.|||.|:.|:|...||||....|||
Frog    70 TSQYEYYKIYLVDKEQADSCSIKDKTP--LLNCAKPDQDVKFTIKFQEFSPNLWGLEFQRDKDYY 132

  Fly   329 FISTS--SKDDLYRRIGGRCSTNNMKVVFKVCCAPE-------------DNNKTTALSNSKSVTD 378
            .||||  |.:.:..:.||.|.|..||::.||...|:             |....|   |.||.|
Frog   133 IISTSNGSLEGVDNQEGGVCVTKAMKILMKVGQDPDFHIHQGSSSTRRPDQESGT---NGKSST- 193

  Fly   379 TGGAINVNIANNDESHVNSH----GNNIAIGTNIGINGGQII---------------------GG 418
            |...:|.....:.|.|...|    |:.:|:..  ||..|.||                     ..
Frog   194 TSPHVNGPKGPSTEGHNAGHSSILGSEVALFA--GIASGCIIFIVIIITLVVLLLKYRRRHRKHS 256

  Fly   419 PQ-SAGIPINPL-----SGNNN 434
            || :..:.::.|     |||||
Frog   257 PQHTTTLSLSTLATPKRSGNNN 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ephrin	NP_651927.1	Ephrin_ectodomain	217..358	CDD:259861	49/143 (34%)
Ephrin	NP_651927.1	PigN	<557..>622	CDD:282796
efnb2	NP_001093709.1	Ephrin-B_Ectodomain	29..164	CDD:259897	49/144 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9055
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001210
OrthoInspector	1	1.000	-	-		otm47820
Panther	1	1.100	-	-	O	PTHR11304
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4391
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.040