DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34124 and Eml4

DIOPT Version :9

Sequence 1:	NP_001036333.1	Gene:	CG34124 / 4379887	FlyBaseID:	FBgn0083960	Length:	2003	Species:	Drosophila melanogaster
Sequence 2:	XP_006525218.1	Gene:	Eml4 / 78798	MGIID:	1926048	Length:	999	Species:	Mus musculus

Alignment Length:	761	Identity:	151/761 - (19%)
Similarity:	273/761 - (35%)	Gaps:	192/761 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTTQESDLLGE---------------EEELENENDV--SFPRDIVSVEHSFGY---DCKKLFNL 45
            |.|.:::...||               ..:::|.:|:  ..|.:.:.:|..:||   ||:.  |:
Mouse   236 MSTREKNSQEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWVYGYRGKDCRA--NV 298

  Fly    46 VLVDSDTLVFASGNFLNYFS----ISRQEISFQETVYGCGVGFITKNEHPDYTNLFT-----VGE 101
            .|:.:..:|:...:.:..|:    ..|..:...:.|....|       |||...:.|     |.:
Mouse   299 YLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVRCLAV-------HPDKIRIATGQIAGVDK 356

  Fly   102 NG--ARPTVFIYEYPSLNVRVKLLNAAQNCFTAGSYNK-TGELFASQA----------GYPDFII 153
            :|  .:|.|.:::..||        ...:....|::.: .|.|..|:|          ...:.::
Mouse   357 DGRPLQPHVRVWDSVSL--------TTLHVIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHML 413

  Fly   154 TIWRWENAEVVLRAKSFQSDILFVHF--SEHNPILLCSSGLSHIKFWKMANTFTGLKL---KGDL 213
            |:|.|:....:...|:....:|.|.|  ::.|.|:.|  |.|||.||    |::|..|   :|..
Mouse   414 TVWDWQKKSKIAEIKTTNEVVLAVEFHPTDANTIITC--GKSHIFFW----TWSGNSLTRKQGIF 472

  Fly   214 GRFGKTDFSDIYAMYMLQDENVISGSDWGNMLLWQAGLIK----------FEICRKGRKPCHTKP 268
            |::.|..|  :..:..|.:.:|::|...|.||:|...:::          ::|.|:.:  .|...
Mouse   473 GKYEKPKF--VQCLAFLGNGDVLTGDSGGVMLIWSKTMVEPPPGKGPKGVYQINRQIK--AHDGS 533

  Fly   269 I-TRITMKNGEVTT-VGMDGYVRVWYWETVDLADPPEDDLFVEIDPIYEFKIAD--------VEL 323
            : |...|:||.:.| .|.|..:.:|           :.||.:|    .|.::.|        .|.
Mouse   534 VFTLCQMRNGMLLTGGGKDRKIILW-----------DHDLNLE----REIEVPDQYGTIRAVAEG 583

  Fly   324 RCMQKI---------------------------------HPFDESDFTHYAQDGNGGIWFCDINT 355
            |..|.:                                 |||.:...| .|||....:|    |:
Mouse   584 RAEQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLT-CAQDRQVCMW----NS 643

  Fly   356 YDVPQKPRKLYSCIGGKVLAAQMSPVSPHFLCMSESGKLFVYQYDEQRLILEKEFPAEGVDVIWL 420
            .:...:..:|....|.   .|...|........:.||:.||...:.:.|:.......|.:.|:
Mouse   644 VEHRLEWTRLVDEPGH---CADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVM-- 703

  Fly   421 DTNISVKGTELVAAFKDGILRQMYLDLSNGERPKMTRVRAFKAHTSPITALTVSRNSSLLLTGSA 485
              ..||.||.|.....|..: .:|..|.||.  |.:|......|:|.||.|..|.::..:::.|.
Mouse   704 --RYSVDGTLLAVGSHDNFI-YLYTVLENGR--KYSRYGKCTGHSSYITHLDWSPDNKHIMSNSG 763

  Fly   486 DKSIFIYQL--------SRDEHQMVDMRP----LGFVQFAAIP--------NCFYWHETEPTVVL 530
            |..|..:.:        :|.:.:.:|...    |||..|...|        |..........:.:
Mouse   764 DYEILYWDIENGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRRVIAV 828

  Fly   531 VG--CKSGDLYEYNIRTEVTDHETYLSYNITENSRMRHTKFASIKSRIRRDIHRENVKKRKERKR 593
            ..  ||. .|::|...........|.::    :|.:.:..|.      ..|.|..:...:.....
Mouse   829 ADDFCKV-HLFQYPCSKAKAPSHKYSAH----SSHVTNVSFT------HNDSHLISTGGKDMSII 882

  Fly   594 ERKMNEVEKLKKANPGLQIDIESALADSEPDEEEEPLHIPTVPNAI 639
            :.|:  ||||......:..|.......:...|...|.:.|.:|.::
Mouse   883 QWKL--VEKLPVPQNEVITDASVTKTPASSSETARPSNSPPLPPSL 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34124	NP_001036333.1	WD40 repeat	90..124	CDD:293791	10/40 (25%)
		WD40 repeat	131..166	CDD:293791	8/45 (18%)
		WD40	135..493	CDD:295369	94/426 (22%)
		WD40	163..574	CDD:225201	102/490 (21%)
		WD40 repeat	174..217	CDD:293791	17/47 (36%)
		WD40 repeat	270..318	CDD:293791	12/48 (25%)
		WD40 repeat	323..370	CDD:293791	12/79 (15%)
		WD40 repeat	414..462	CDD:293791	13/47 (28%)
		WD40 repeat	468..511	CDD:293791	12/54 (22%)
Eml4	XP_006525218.1	HELP	247..318	CDD:367505	12/72 (17%)
		WD40	325..678	CDD:392136	81/400 (20%)
		WD40 repeat	335..383	CDD:293791	11/62 (18%)
		WD40 repeat	388..428	CDD:293791	7/39 (18%)
		WD40 repeat	435..472	CDD:293791	16/42 (38%)
		WD40 repeat	481..529	CDD:293791	9/49 (18%)
		WD40	525..885	CDD:392136	76/402 (19%)
		WD40 repeat	535..572	CDD:293791	12/51 (24%)
		WD40 repeat	577..612	CDD:293791	3/34 (9%)
		WD40 repeat	618..655	CDD:293791	10/41 (24%)
		WD40 repeat	660..695	CDD:293791	7/34 (21%)
		WD40 repeat	701..741	CDD:293791	13/46 (28%)
		WD40 repeat	746..781	CDD:293791	7/34 (21%)
		WD40 repeat	814..851	CDD:293791	5/37 (14%)
		WD40 repeat	859..886	CDD:293791	3/32 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2106
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900