DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34124 and EML6

DIOPT Version :9

Sequence 1:	NP_001036333.1	Gene:	CG34124 / 4379887	FlyBaseID:	FBgn0083960	Length:	2003	Species:	Drosophila melanogaster
Sequence 2:	XP_016859587.1	Gene:	EML6 / 400954	HGNCID:	35412	Length:	1966	Species:	Homo sapiens

Alignment Length:	632	Identity:	130/632 - (20%)
Similarity:	233/632 - (36%)	Gaps:	169/632 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EEEELENENDVSFPRDIV---SVEHSFGY---DCKKLFNL-VLVDSDTLVF--ASGNFLNYFSIS 67
            :.|:|: :|:::..:.:|   :::|.|||   ||:.  || .|.|...::|  |:...:...|..
Human  1352 QPEKLQ-KNNITKKKKLVEELALDHVFGYRGFDCRN--NLHYLNDGADIIFHTAAAGIVQNLSTG 1413

  Fly    68 RQEISFQETVYGCGVGFITKNEHPDYTNLFTVGENGARPTVFIYEYPSLNVRVKLLNAAQNCFTA 132
            .|....:.|   ..:..:|.|:||.|.|:....:.|..|::.|::     ...|...:...||.:
Human  1414 SQSFYLEHT---DDILCLTVNQHPKYRNVVATSQIGTTPSIHIWD-----AMTKHTLSMLRCFHS 1470

  Fly   133 G-----SYNKTGELFASQAGYPDFIITIWRW-ENAEVVLRAKSFQSDILFVHFSEHNPILLCSSG 191
            .     :::.||:|..|....|:..||:||| |.|:|..|....:. |..|.|...:.....|.|
Human  1471 KGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLER-IFVVEFRPDSDTQFVSVG 1534

  Fly   192 LSHIKFWKMAN-------------------------------TFTGLKLKGD---------LGRF 216
            :.|:|||.:|.                               |||| .:.||         :...
Human  1535 VKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLSVAFGANNLTFTG-AINGDVYVWKDHFLIRLV 1598

  Fly   217 GKTDFSDIYAMY-MLQDENVISG------SDWGNMLLWQAGLIKFEICRK-----------GRKP 263
            .|.....::.|| .|:|..:::|      .:.|.:.||..   :.:.||.           .|..
Human  1599 AKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQ---EMKRCRAFQLETGQLVECVRSV 1660

  Fly   264 CHTKPITRITMKNGEVTTVG---------MDGYVRVWYWETVDLADPPEDDLFVEIDPIYEFKIA 319
            |..|....:..|:||:..||         :||::....|   .||..|..|||:........:|.
Human  1661 CRGKGKILVGTKDGEIIEVGEKNAASNILIDGHMEGEIW---GLATHPSKDLFISASNDGTARIW 1722

  Fly   320 DV-ELRCMQKIHPFDESDFTHYAQDG--------NGGIWFCDINTYDVPQKPRKLYSCI------ 369
            |: :.:.:.|:.....:....|:.||        ||......:|:..|..|.|...|.|
Human  1723 DLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRIS 1787

  Fly   370 -GGKVLAAQMSPVSPHFLCMSESGKL--FVYQYDEQRLILEKEFPAEG----------------- 414
             ..:.||...|..:..|..:::...|  ..|..|....:::.:|.|:|
Human  1788 PDNRFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEV 1852

  Fly   415 -----------VDVIWLDTNISVKGTELV---------AAFKDGILRQMYLDLSNGE-------- 451
                       ::.|...:..||.|.|::         |......:....|::..|:
Human  1853 PLGKQVTEAVVIEKITWASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLF 1917

  Fly   452 ----RPKMTRVRAFKAHTSPITALTVSRNSSLLL-TGSADKSIFIYQ 493
                ..|..:.:.:..|::.:|.:..|.:...:: ||..|.|:|:::
Human  1918 DFPCTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWR 1964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34124	NP_001036333.1	WD40 repeat	90..124	CDD:293791	8/33 (24%)
		WD40 repeat	131..166	CDD:293791	13/40 (33%)
		WD40	135..493	CDD:295369	99/493 (20%)
		WD40	163..574	CDD:225201	87/466 (19%)
		WD40 repeat	174..217	CDD:293791	16/82 (20%)
		WD40 repeat	270..318	CDD:293791	14/56 (25%)
		WD40 repeat	323..370	CDD:293791	12/61 (20%)
		WD40 repeat	414..462	CDD:293791	10/96 (10%)
		WD40 repeat	468..511	CDD:293791	7/27 (26%)
EML6	XP_016859587.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910