DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34124 and Cfap44

DIOPT Version :9

Sequence 1:	NP_001036333.1	Gene:	CG34124 / 4379887	FlyBaseID:	FBgn0083960	Length:	2003	Species:	Drosophila melanogaster
Sequence 2:	XP_038944822.1	Gene:	Cfap44 / 363782	RGDID:	1559942	Length:	1845	Species:	Rattus norvegicus

Alignment Length:	1860	Identity:	502/1860 - (26%)
Similarity:	879/1860 - (47%)	Gaps:	249/1860 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DLLGEEEELENENDVSF-------------------PRDIVSVEHSFGYDCKKLFNLVLVDSDTL 53
            :|..|.||::.:...:|                   |...:::.||||||||:..||.|:|::||
  Rat    79 ELKEEPEEVKKKLSETFYYDYLELISTPYVSSPDRIPLYFLALNHSFGYDCKRRANLQLLDNNTL 143

  Fly    54 VFASGNFLNYFSISRQEISFQETVYGCGVGFITKNEHPDYTNLFTVGENGARPTVFIYEYPSLNV 118
            ::.:||.:.......:...:.::..|.|:|.|  ..|||.| .|.|.|.|:.|.:.|||||||..
  Rat   144 MYIAGNQMVLLDFKNKTQMYLQSSSGQGIGAI--GVHPDKT-YFAVAEKGSFPKIIIYEYPSLKP 205

  Fly   119 RVKLLNAAQNCFTAGSYNKTGELFASQAGYPDFIITIWRWENAEVVLRAKSFQSDILFVHFSEHN 183
            ...|.:..:..:....:|..|.|.||...:||:.||||.|:..:.:||.|:|..|:..|.|:..|
  Rat   206 YRILQDGTEKAYAYVDFNNEGNLLASVGCHPDYTITIWDWKGEQPILRTKAFSQDVFKVTFNPDN 270

  Fly   184 PILLCSSGLSHIKFWKMANTFTGLKLKGDLGRFGKTDFSDIYAMYMLQDENVISGSDWGNMLLWQ 248
            ...|.:||..|||||:||.|||||||:|.|||||||..:||.....|.|..|:|||:|||:|||:
  Rat   271 DEQLTTSGSGHIKFWEMAFTFTGLKLQGSLGRFGKTSTTDIEGYAELPDGKVLSGSEWGNLLLWE 335

  Fly   249 AGLIKFEICRKGRKPCHTKPITRITMKNGEVTTVGMDGYVRVWYWETVDLADPPEDDLFVEIDPI 313
            ..|||.|:||.|.|.||...|.:|.:..|||.|.|.||.||:|.:||:|.||..:|...:||:||
  Rat   336 GSLIKVELCRTGMKSCHNGSINQIMLDEGEVITAGSDGSVRIWDFETIDTADVIDDSGLLEIEPI 400

  Fly   314 YEFKI-ADVELRCMQKIHPFDESDFTHYAQDGNGGIWFCDINTYDVPQKPRKLYSCIGGKVLAAQ 377
            .|..: ..|.|..|.|::....:.:  .|||.||.||..|::..::.|.|..|:|...|.:.|..
  Rat   401 NELHVDKSVNLFSMIKMNEVGNNFW--LAQDANGAIWKLDLSFSNITQDPECLFSFHSGAIAALD 463

  Fly   378 MSPVSPHFLCMSESGKLFVYQYDEQRLILEKEFPAEGVDVIWLDTNISVKGTELVAAFKDGILRQ 442
            :||::......:....:.||.:..:.|:::.:|...|..:||....:|:.|:::|..|:||::|
  Rat   464 VSPLTYLMATTALDCSVRVYDFASKNLLVQMKFKQGGTTLIWAPLTVSISGSQIVVGFQDGVVR- 527

  Fly   443 MYLDLSNGERPKMTRVRA---------------FKAHTSPITALTVSRNSSLLLTGSADKSIFIY 492
             .|:|.:   ||...|.|               ||.||..:|||...|:..:|.|||.||::|.:
  Rat   528 -ILELFD---PKGLTVFAGRKKLLDAELHLKYVFKPHTEVVTALAYERDGEVLATGSDDKTVFFF 588

  Fly   493 QLSRDEHQMVDMRPLGFVQFAAIPNCFYW--HETEPTVVLVGCKSGDLYEYNIRT-EVTDHETYL 554
            .:.:      :.:|:|:...........|  |....:.:|:.|.:|.:.|....| :..|.:..:
  Rat   589 DVEK------EYKPIGYFNTPGPIRQLMWSPHSHPESTLLIICGNGYILECLCPTIKDVDDQNLV 647

  Fly   555 SYNITENSRMRHTKFASIKSRIRRDI---HRENVKKRKERKRERKMNEVEKLKKA--NPGLQIDI 614
            ::.|.: ..:|...|:|:||:|.|.:   .||..|:.:|::||.:..::.:.|:|  ...:|.:.
  Rat   648 TFAIPD-MLVRCFHFSSVKSKILRYMEVQRREKQKELREKEREERKRKLMEEKEALGEQEIQEEE 711

  Fly   615 ESALADSEPDEEEEPL---HIPTVPNAIIWLRYTLRDTIWVSMAGYDAGYIYELEFN-------- 668
            |.|..:.|.:||||||   ..|..|:.|:...|::....|||:..||:|::|..:|.
  Rat   712 EEASEEEEEEEEEEPLPEIFTPPTPSPILCGFYSVPGKFWVSLGNYDSGFLYHCQFPPHLVKDDF 776

  Fly   669 ---AAEPTRATIIAEADDIEIHSYCIIDEFIIF--GLHNGRIRINRINPDN--FTDLSEFRIYPM 726
               ..||....|:...||..|.:......:.:.  |:.||.||...::.::  ...|.::..:.:
  Rat   777 QKLENEPFDFRILENTDDNPIRTITFSSNYTMMFCGMKNGAIRTYFLSENDPFLISLQDYWHFNV 841

  Fly   727 HDGLKGTIPKIDISYSGEHLLTIGYDGNVFLHKWNGPKIVRNKVRDKLPP---------LPEGVT 782
            ||...|::..|..|:..::|:|.|.|||:|:.......|::.:.:..:|.         .||.:.
  Rat   842 HDNNYGSVKSIFPSFDDQYLVTAGEDGNIFVFDIFSEFIIQKEAKAHVPSPRYGIEAEVAPEDID 906

  Fly   783 QIPDIEPEACSLEQEKINAE---LRRQQEAADAHDRDVLSKIGALQNVYFDIIRINEELPPGLRA 844
                 :|:|.|:|..:...|   |.::.|...|..|   .:|..|:|.::.::.:|:|||..::.
  Rat   907 -----DPKAYSIENARRKREHDKLMKKVEELKAQKR---QQIKILRNEFWKLLALNKELPKHMQF 963

  Fly   845 KDTDLLLDDRITRQIRNELQAELDDVREDLAYDLEFAQVGHTKLYNHFLKELVQVPFTVAPLRAN 909
            ..|:..:|.:|..:|..:...:::.|.::||::.:..::|..|:.:.|.:.|......|..::::
  Rat   964 HRTEFNIDAKIHAEIHKKTSIKIEQVEKELAWEKQKYELGLKKVQDRFREPLESDTVVVYAIQSD 1028

  Fly   910 VPGVSTFRLQALGEEHAQIKQDIEDRLKREHDMGLHDYVAPERSD---------ESIGEPPPESF 965
             ..::::||         :|.....:|||           |.::|         |..|....||
  Rat  1029 -HQIASYRL---------VKPSKYSKLKR-----------PSQTDRRPSKMERFEKEGPGKRES- 1071

  Fly   966 FFGRDP---------------KSIEPRFSKKMM---------RLLTRYRKRQIFEVRRIFDWDKL 1006
              .||.               |...||...::|         :|:.:..:.|:..::|..:|::|
  Rat  1072 --QRDTGGSLSLQEEVVLEKGKKARPRTLSEIMVENQIEKTRKLVQQAERAQLKILQRKREWEEL 1134

  Fly  1007 ERQKPDPNRNHPDDDAQIEDAKRNLGDFKLKIGSDYE-PKSSETLTQKYIEVVECREQYFAMVDA 1070
            .:.|||.:...|.|...|::|:..:|||.||..|||: |:.......|       :|:...::|.
  Rat  1135 YKSKPDDDYEDPRDVQAIKEAQTFMGDFNLKTASDYKIPEHMRINAAK-------KEEELGLLDT 1192

  Fly  1071 --------FNQMVLDLRERKGELDQFITAKRNRLAVIHNYLPEPDRQPLDPIQEIDMDLEYPELN 1127
                    .|:.:|.||:.|..:.:.|......|..|.:.:|......:..:.:|     |||
  Rat  1193 MAHGKKRYMNKCILSLRDLKLAVIEEIQCLVQELKTIQSSIPPAKHMTIPQVPQI-----YPE-- 1250

  Fly  1128 LIEHYTPGCGVEIDDILTLEHSVDQVIARMAPMRSTANVSLFS-------LHGLDVPELHEHTAF 1185
                ..|....:.|:...|.....|...|.....|.::....|       |..|.:....|....
  Rat  1251 ----EVPERRFQYDEETLLRFKRKQQKQRQDDKSSNSSKQSGSGASTGGGLGFLKLSSGKEGDLT 1311

  Fly  1186 TMLQISKLNRSLPNAELDEELLKLPPKSDPAYFELNDDGQVPYMM----ETRHRWLRQLLVEQNA 1246
            |...:|:.:::.       ..|:||..::   ||..:.|.|...:    |.:|.:::|.|..:
  Rat  1312 TRDSLSRSSKAF-------AFLELPKATE---FEKAEPGDVELEIMKRDEVKHLYMQQFLCNR-- 1364

  Fly  1247 IRTEVDEEVRQFDKALEKLQVRRFHVKMDAEFMTAFMN--SLNQELYILRDSEEIETQLLLNAKT 1309
                :.|....||..|..|  |...:|:|.:...:.::  :|.||:.:|::.|:.|..|.....:
  Rat  1365 ----IKELTVTFDAELHLL--RHQKLKLDTQMKLSDLHHVTLFQEMLLLKNFEKQENILQERVNS 1423

  Fly  1310 AMSTRNDLQMVINSTNRQLDELRRNIDKLGEQIVALQVLFATTV-KGHKFFDFLRRIFKKKWRPP 1373
            ......|:|..||.|.::::|.:..|:||.||..:|...|.:.: :.:||.:||.::.|||.:..
  Rat  1424 LDREEQDMQWKINETLKEMEEKKNEINKLQEQEKSLYSGFQSALGENNKFANFLMKVLKKKIKRA 1488

  Fly  1374 K---VSRGD-DESSSSSSSSSSSSEDEQADNKSLDSLDMTTIRLDEATCPTGLDRSLYDLAFSMR 1434
            |   |...| ||.|..||...||.|.::.::.|.|.:      .|::.||:..|.||::||..:|
  Rat  1489 KKKEVEEADEDEESEESSEEESSLESDEDESGSEDEV------FDDSICPSNCDVSLFELALQLR 1547

  Fly  1435 SDRHDLERNVRELTREVENKRKEIAEMQIKMKFHEEVYQREKNALLQFRRNRQQEVNKVHISAIL 1499
            ..|.|:|..:.|..:.|:|.:||...:..|:|.........:.||..::|.:||.:|::.:...|
  Rat  1548 EKRLDIEEALVEEKKVVDNLKKEYDTISKKVKVVATNLNAAEEALEAYQREKQQRLNELLVVIPL 1612

  Fly  1500 RMDQLQHFYDGDDYRDLSKAILFDADMLVDLRRRADQLSEETLATKRWHRINFIHLRRMNTDIKF 1564
            ::.|:::...|:...|||..::|....|..|:.|..||.||....::.::......:.:..:.:.
  Rat  1613 KLHQIEYVVFGEVPEDLSGTLIFSNHSLDRLQERIVQLQEENAKQQKLNKECRERRKLLIREKRE 1677

  Fly  1565 MRFEITRLEEEIRQAMMKKFGIIVNLDELEEEVLRRYIFDLETNAED-ELMALEKELLEKQKELA 1628
            |...|::::|.:|:.|:.|||.:::|:.|:       ...:.|..|: ::..|.|| |...||:.
  Rat  1678 MAKTISKMDETVRELMISKFGRVIDLEALQ-------TLSVNTTLEELKIKKLRKE-LSNAKEIR 1734

  Fly  1629 RCEE-------ELVLETQNNTEKVNIMTVLREENNILRTLLD-IQNKNYAKWANPNALNLSYDIE 1685
            ..||       :|:::|:.:|:|::.|..|..|...|.:.|: :||:....:..|...::... :
  Rat  1735 MWEEKIAQVRWDLMMKTKEHTKKLHQMNDLCLEKKRLDSRLNTLQNQQGNAFQGPRKADIVAK-Q 1798

  Fly  1686 KLRGIEKSLLDQIECLEREICALRLKS-------KPLQIN 1718
            |:..:.::..::|..|:.||..||.|.       .|:|.|
  Rat  1799 KVTELVQTQSEKISALKEEIALLRKKGGLILPPITPMQEN 1838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34124	NP_001036333.1	WD40 repeat	90..124	CDD:293791	17/33 (52%)
		WD40 repeat	131..166	CDD:293791	12/34 (35%)
		WD40	135..493	CDD:295369	147/373 (39%)
		WD40	163..574	CDD:225201	149/429 (35%)
		WD40 repeat	174..217	CDD:293791	24/42 (57%)
		WD40 repeat	270..318	CDD:293791	22/47 (47%)
		WD40 repeat	323..370	CDD:293791	15/46 (33%)
		WD40 repeat	414..462	CDD:293791	16/62 (26%)
		WD40 repeat	468..511	CDD:293791	13/42 (31%)
Cfap44	XP_038944822.1	WD40 repeat	172..211	CDD:293791	19/41 (46%)
		WD40	207..597	CDD:225201	148/402 (37%)
		WD40 repeat	217..256	CDD:293791	14/38 (37%)
		WD40 repeat	261..303	CDD:293791	23/41 (56%)
		WD40 repeat	309..350	CDD:293791	21/40 (53%)
		WD40 repeat	401..454	CDD:293791	16/54 (30%)
		WD40 repeat	459..494	CDD:293791	6/34 (18%)
		WD40 repeat	501..558	CDD:293791	15/61 (25%)
		WD40	553..>662	CDD:421866	27/115 (23%)
		WD40 repeat	564..598	CDD:293791	12/39 (31%)
		WD40 repeat	797..840	CDD:293791	7/42 (17%)
		WD40 repeat	849..890	CDD:293791	10/40 (25%)
		PTZ00121	<914..1458	CDD:173412	129/606 (21%)
		Smc	1539..>1824	CDD:224117	73/293 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351157
Domainoid	1	1.000	295	1.000	Domainoid score	I1427
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75085
Inparanoid	1	1.050	619	1.000	Inparanoid score	I847
OMA	1	1.010	-	-		QHG56440
OrthoDB	1	1.010	-	-		D50355at33208
OrthoFinder	1	1.000	-	-		FOG0009905
OrthoInspector	1	1.000	-	-		oto95448
orthoMCL	1	0.900	-	-		OOG6_103568
Panther	1	1.100	-	-	LDO	PTHR13720
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X7605
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910