DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG34124 and Eml4

DIOPT Version :9

Sequence 1:NP_001036333.1 Gene:CG34124 / 4379887 FlyBaseID:FBgn0083960 Length:2003 Species:Drosophila melanogaster
Sequence 2:XP_038968076.1 Gene:Eml4 / 313861 RGDID:1304690 Length:979 Species:Rattus norvegicus


Alignment Length:628 Identity:132/628 - (21%)
Similarity:233/628 - (37%) Gaps:169/628 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDTTQESDLLGE---------------EEELENENDV--SFPRDIVSVEHSFGY---DCKKLFNL 45
            |.|.::|...||               ..:::|.:|:  ..|.:.:.:|..:||   ||:.  |:
  Rat   225 MSTREKSSQEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWVYGYRGKDCRA--NV 287

  Fly    46 VLVDSDTLVFASGNFLNYFS----ISRQEISFQETVYGCGVGFITKNEHPDYTNLFT-----VGE 101
            .|:.:..:|:...:.:..|:    ..|..:...:.|....|       |||...:.|     |.:
  Rat   288 YLLPTGEIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAV-------HPDKIRMATGQIAGVDK 345

  Fly   102 NG--ARPTVFIYEYPSLNVRVKLLNAAQNCFTAGSYNK-TGELFASQA----------GYPDFII 153
            :|  .:|.|.:::..||        :..:....|::.: .|.|..|:|          ...:.::
  Rat   346 DGRPLQPHVRVWDSVSL--------STLHVIGLGTFERGVGCLDFSKADSGVHLCVIDDSNEHML 402

  Fly   154 TIWRWENAEVVLRAKSFQSDILFVHF--SEHNPILLCSSGLSHIKFWKMANTFTGLKL---KGDL 213
            |:|.|:....|...|:....:|.|.|  ::.|.|:.|  |.|||.||    |::|..|   :|..
  Rat   403 TVWDWQRKSKVAEIKTTNEVVLAVEFHPTDANTIITC--GKSHIFFW----TWSGNSLTRKQGIF 461

  Fly   214 GRFGKTDFSDIYAMYMLQDENVISGSDWGNMLLWQAGLIK----------FEICRKGRKPCHTKP 268
            |::.|..|  :..:..|.:.:|::|...|.||:|....|:          ::|.|:.:  .|...
  Rat   462 GKYEKPKF--VQCLAFLGNGDVLTGDSGGVMLIWSKTTIEPPPGKGPKGVYQISRQIK--AHDGS 522

  Fly   269 I-TRITMKNGEVTT-VGMDGYVRVWYWETVDLADPPEDDLFVEIDPIYEFKIAD--------VEL 323
            : |...|:||.:.| .|.|..:.:|           :.||.:|    .|.::.|        .|.
  Rat   523 VFTLCQMRNGMLLTGGGKDRKIILW-----------DHDLNLE----REIEVPDQYGTIRAVAEG 572

  Fly   324 RCMQKI---------------------------------HPFDESDFTHYAQDGNGGIWFCDINT 355
            :..|.:                                 |||.:...| .|||....:|    |:
  Rat   573 KAEQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLT-CAQDRQVCMW----NS 632

  Fly   356 YDVPQKPRKLYSCIGGKVLAAQMSPVSPHFLCMSESGKLFVYQYDEQRLILEKEFPAEGVDVIWL 420
            .:...:..:|....|.   .|...|........:.||:.||...:.:.|:.......|.:.|:  
  Rat   633 VEHRLEWTRLVDEPGH---CADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVM-- 692

  Fly   421 DTNISVKGTELVAAFKDGILRQMYLDLSNGERPKMTRVRAFKAHTSPITALTVSRNSSLLLTGSA 485
              ..||.||.|.....|..: .:|....||.  |.:|......|:|.||.|..|.::..:::.|.
  Rat   693 --RYSVDGTLLAVGSHDNFI-YLYAVSENGR--KYSRYGKCTGHSSYITHLDWSPDNKHIMSNSG 752

  Fly   486 DKSIFIYQL--------SRDEHQMVDMRP----LGFVQFAAIP 516
            |..|..:.:        :|.:.:.:|...    |||..|...|
  Rat   753 DYEILYWDIENGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWP 795

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34124NP_001036333.1 WD40 repeat 90..124 CDD:293791 10/40 (25%)
WD40 repeat 131..166 CDD:293791 9/45 (20%)
WD40 135..493 CDD:295369 94/426 (22%)
WD40 163..574 CDD:225201 94/424 (22%)
WD40 repeat 174..217 CDD:293791 17/47 (36%)
WD40 repeat 270..318 CDD:293791 12/48 (25%)
WD40 repeat 323..370 CDD:293791 11/79 (14%)
WD40 repeat 414..462 CDD:293791 12/47 (26%)
WD40 repeat 468..511 CDD:293791 12/54 (22%)
Eml4XP_038968076.1 TD_EMAP4 6..64 CDD:409271
HELP 236..307 CDD:397490 12/72 (17%)
WD40 314..667 CDD:421866 82/400 (21%)
WD40 repeat 323..369 CDD:293791 12/60 (20%)
WD40 repeat 378..416 CDD:293791 8/37 (22%)
WD40 repeat 423..464 CDD:293791 17/46 (37%)
WD40 repeat 471..518 CDD:293791 10/48 (21%)
WD40 513..874 CDD:421866 64/315 (20%)
WD40 repeat 523..567 CDD:293791 13/58 (22%)
WD40 repeat 607..644 CDD:293791 10/41 (24%)
WD40 repeat 649..684 CDD:293791 7/34 (21%)
WD40 repeat 690..730 CDD:293791 12/46 (26%)
WD40 repeat 735..770 CDD:293791 7/34 (21%)
WD40 repeat 803..842 CDD:293791
WD40 repeat 848..875 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG2106
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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