DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34124 and EML4

DIOPT Version :9

Sequence 1:	NP_001036333.1	Gene:	CG34124 / 4379887	FlyBaseID:	FBgn0083960	Length:	2003	Species:	Drosophila melanogaster
Sequence 2:	XP_005264324.1	Gene:	EML4 / 27436	HGNCID:	1316	Length:	992	Species:	Homo sapiens

Alignment Length:	837	Identity:	158/837 - (18%)
Similarity:	297/837 - (35%)	Gaps:	228/837 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDTTQESDLLGE---------------EEELENENDV--SFPRDIVSVEHSFGY---DCKKLFNL 45
            |.|.:::...||               ..:::|.:|:  ..|.:.:.:|.::||   ||:.  |:
Human   225 MSTREKNSQEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPEKLKLEWAYGYRGKDCRA--NV 287

  Fly    46 VLVDSDTLVFASGNFLNYFS----ISRQEISFQETVYGCGVGFITKNEHPDYTNLFT-----VGE 101
            .|:.:..:|:...:.:..|:    ..|..:...:.|....:       |||...:.|     |.:
Human   288 YLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAI-------HPDKIRIATGQIAGVDK 345

  Fly   102 NG--ARPTVFIYEYPSLNVRVKLLNAAQNCFTAGSYNK-TGELFASQA----------GYPDFII 153
            :|  .:|.|.:::..:|:. ::::.       .|::.: .|.|..|:|          ...:.::
Human   346 DGRPLQPHVRVWDSVTLST-LQIIG-------LGTFERGVGCLDFSKADSGVHLCIIDDSNEHML 402

  Fly   154 TIWRWENAEVVLRAKSFQSDILFVHF--SEHNPILLCSSGLSHIKFWKMANTFTGLKL---KGDL 213
            |:|.|:........|:....:|.|.|  ::.|.|:.|  |.|||.||    |::|..|   :|..
Human   403 TVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITC--GKSHIFFW----TWSGNSLTRKQGIF 461

  Fly   214 GRFGKTDFSDIYAMYMLQDENVISGSDWGNMLLWQAGLIK----------FEICRKGRKPCHTKP 268
            |::.|..|  :..:..|.:.:|::|...|.||:|....::          ::|.::.:  .|...
Human   462 GKYEKPKF--VQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIK--AHDGS 522

  Fly   269 I-TRITMKNGEVTT-VGMDGYVRVWYWETVDLADPPEDDLFVEIDPIYEFKIADVELRCMQKI-- 329
            : |...|:||.:.| .|.|..:.:|     |....||.:  :|:...|....|..|.:..|.:
Human   523 VFTLCQMRNGMLLTGGGKDRKIILW-----DHDLNPERE--IEVPDQYGTIRAVAEGKADQFLVG 580

  Fly   330 -------------------------------HPFDESDFTHYAQDGNGGIWFCDINTYDVPQKPR 363
                                           |||.:...| .|||....:|    |:.:...:..
Human   581 TSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLT-CAQDRQVCLW----NSMEHRLEWT 640

  Fly   364 KLYSCIGGKVLAAQMSPVSPHFLCMSESGKLFVYQYDEQRLILEKEFPAEGVDVIWLDTNISVKG 428
            :|....|.   .|...|........:.||:.||...:.:.|:.......|.:.|:    ..|:.|
Human   641 RLVDEPGH---CADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVM----RYSIDG 698

  Fly   429 TELVAAFKDGILRQMYLDLSNGERPKMTRVRAFKAHTSPITALTVSRNSSLLLTGSADKSIFIYQ 493
            |.|.....|..: .:|:...||.  |.:|......|:|.||.|..|.::..:::.|.|..|..:.
Human   699 TFLAVGSHDNFI-YLYVVSENGR--KYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWD 760

  Fly   494 L--------SRDEHQMVDMRP----LGFVQFAAIP--------NCFYWHETEPTVVLVG--CKSG 536
            :        :|.:.:.:|...    |||..|...|        |..........:.:..  ||.
Human   761 IPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVRSHNRKVIAVADDFCKV- 824

  Fly   537 DLYEY---------NIRTEVTDHETYLSY--------------------------NITENSRMRH 566
            .|::|         :..:..:.|.|.:|:                          ::.:|..:..
Human   825 HLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVAD 889

  Fly   567 TKFASIKSRIRRDIHRENVKKRKERKRERKMNEVEKLKKANPG-LQIDIESALADSEPDEEEEPL 630
            |............:.:.|.......:...:..|.|....::|. |:..:|..:..||...|||
Human   890 TTLTKAPVSSTESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEE-- 952

  Fly   631 HIPTVPNAIIWLRYTLRDTIWVSMAGY-DAGY-IYELEFN--AAEPTRATIIAEADD 683
                                  |..|. |.|. :||...|  :.|..:||::.:..|
Human   953 ----------------------SEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQD 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34124	NP_001036333.1	WD40 repeat	90..124	CDD:293791	9/40 (23%)
		WD40 repeat	131..166	CDD:293791	8/45 (18%)
		WD40	135..493	CDD:295369	91/418 (22%)
		WD40	163..574	CDD:225201	101/517 (20%)
		WD40 repeat	174..217	CDD:293791	17/47 (36%)
		WD40 repeat	270..318	CDD:293791	13/48 (27%)
		WD40 repeat	323..370	CDD:293791	11/79 (14%)
		WD40 repeat	414..462	CDD:293791	11/47 (23%)
		WD40 repeat	468..511	CDD:293791	12/54 (22%)
EML4	XP_005264324.1	DUF4887	100..234	CDD:292845	2/8 (25%)
		HELP	236..307	CDD:281450	12/72 (17%)
		WD40	291..753	CDD:225201	103/508 (20%)
		WD40	314..667	CDD:295369	78/392 (20%)
		WD40 repeat	323..369	CDD:293791	10/53 (19%)
		WD40 repeat	378..420	CDD:293791	8/41 (20%)
		WD40 repeat	423..464	CDD:293791	17/46 (37%)
		WD40 repeat	471..518	CDD:293791	8/48 (17%)
		WD40	513..874	CDD:295369	71/385 (18%)
		WD40 repeat	523..567	CDD:293791	13/50 (26%)
		WD40 repeat	607..644	CDD:293791	10/41 (24%)
		WD40 repeat	649..684	CDD:293791	7/34 (21%)
		WD40 repeat	690..730	CDD:293791	11/46 (24%)
		WD40	722..>875	CDD:225201	25/153 (16%)
		WD40 repeat	735..770	CDD:293791	7/34 (21%)
		WD40 repeat	803..840	CDD:293791	5/37 (14%)
		WD40 repeat	848..875	CDD:293791	2/26 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2106
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810