DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34124 and Eml3

DIOPT Version :9

Sequence 1:	NP_001036333.1	Gene:	CG34124 / 4379887	FlyBaseID:	FBgn0083960	Length:	2003	Species:	Drosophila melanogaster
Sequence 2:	NP_659121.1	Gene:	Eml3 / 225898	MGIID:	2387612	Length:	897	Species:	Mus musculus

Alignment Length:	887	Identity:	168/887 - (18%)
Similarity:	276/887 - (31%)	Gaps:	351/887 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PRDIVSVEHSFGY---DCKKLFNLVLVDSDTLVFASGNFLNYFSISRQEISFQETVY--GC---- 80
            |.:.:|::..:||   |.:         |:..|..||                |.||  .|
Mouse   245 PPETLSLDWVYGYRGRDSR---------SNLFVLRSG----------------EVVYFIACVVVL 284

  Fly    81 -----------GVGFITKNEHPDYTNLFTVGENGAR-----------------PTVFIYEYPSLN 117
                       |.|......|.|......|..:|.|                 |.|.|::..:|
Mouse   285 YRPGGGPGGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETL- 348

  Fly   118 VRVKLLNAAQNCFTAGSYNKTGELFASQAGYPDFI----------ITIWRWENAEVVLRAKSFQS 172
              :||.......|..|    .|.|..|.|....|:          :::|.......:...||...
Mouse   349 --LKLQEIGLGAFERG----VGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGVKLAEIKSTND 407

  Fly   173 DILFVHFSEHNPILLCSSGLSHIKFWKMANTFTG-------LKLKGDLGRFGKTDFSDIYAMYML 230
            .:|.|.||..:...:.:||.||:.||..:.. ||       .:.:|..|::.|..|  |.....|
Mouse   408 SVLAVGFSPRDSSCIVTSGKSHVHFWNWSGG-TGAPGNGLLARKQGVFGKYKKPKF--IPCFVFL 469

  Fly   231 QDENVISGSDWGNMLLWQAGLIKFEICRKGRKPCHTKPITRITMKNGEVTTVGMDGYVRVWYWET 295
            .|.::::|...||:|.|            ||....:|             |.|..|....  :..
Mouse   470 PDGDILTGDSEGNILTW------------GRSVSDSK-------------TPGRGGAKET--YTI 507

  Fly   296 VDLADPPEDDLFVEIDPIYEFKIADVELRCMQKIHPFDESDFTHYAQDG---NGGIWFCDINTYD 357
            |..|...|..:|.               .|:::              ||   :||
Mouse   508 VAQAHAHEGSIFA---------------LCLRR--------------DGTVLSGG---------- 533

  Fly   358 VPQKPRKLYSCIGGKVLAAQMSPVSPHFLCMSESGKLFVYQYDEQRLILEKEFPAEGVDVIWLDT 422
              .:.|:|... |..::|.|.:.:..||..:              |.|      |||:
Mouse   534 --GRDRRLVQW-GPGLVALQEAEIPEHFGAV--------------RAI------AEGL------- 568

  Fly   423 NISVKGTE-LVAAFKDGILRQMYLDLSNGERPKMTRVRAFKAHTSPITALTVSRNSSLLLTGSAD 486
                 |:| ||...|:.:||.   ||:.|..|      ..:.||..:..|....:.:..||...|
Mouse   569 -----GSELLVGTTKNALLRG---DLAQGFSP------VIQGHTDELWGLCTHPSQNRFLTCGHD 619

  Fly   487 KSIFIYQLSRDEHQM---VDMRPLGFVQFAAIPNCFYWHETEPTVVLVGCKSG-----DLYEYNI 543
            :.:.::  ..:.|.:   :|::..|.        |..:|.: ..||:||..:|     |.....|
Mouse   620 RQLCLW--DGEGHALAWSMDLKETGL--------CADFHPS-GAVVVVGLNTGRWLVLDTETREI 673

  Fly   544 RTEVTDHETYLS----------------------YNI----TENSR----MRHTKFASIKSRIRR 578
            .::|||....||                      |::    |::||    |.|:.|
Mouse   674 VSDVTDGNEQLSVVRYSPDGLYLAIGSHDNMIYIYSVSSCGTKSSRFGRCMGHSSF--------- 729

  Fly   579 DIHRENVKKRKERKRERKMNEVEKLKKANPGLQIDIESALADSEPDEEEEPLHIPTVPNAIIW-- 641
                              :..::..|..|     .|.|...|.|               .:.|
Mouse   730 ------------------ITHLDWSKDGN-----FIMSNSGDYE---------------ILYWDV 756

  Fly   642 --------LRYTLRDTIWVSMAGYDAGYIYELEFNAAEPTRATIIAEADDIEIHSYCIIDEFIIF 698
                    .||..||..|.:.......::|.:..:.::.|           :|:|.|
Mouse   757 AGGCKLLRNRYESRDREWATYTCVLGFHVYGVWPDGSDGT-----------DINSLC-------- 802

  Fly   699 GLHNGRIRINRINPDNFTDLSEFRIYP---------MHDGLKGTIPKIDISYSGEHLLTI-GYDG 753
            ..||.|:   ....|:|..:..|: ||         |:.|....:..:..::...:|::: |.|.
Mouse   803 RSHNERV---VAVADDFCKVHLFQ-YPCARAKAPSRMYSGHGSHVTSVRFTHDDSYLVSLGGKDA 863

  Fly   754 NVFLHKWNGPKIVRNKVRDKLPPLPEGVTQIPDIEPEACSLE 795
            ::|  :|      |........|.|...::.|.:.| |.||:
Mouse   864 SIF--QW------RVLGAGSSGPAPATPSRTPSLSP-ASSLD 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34124	NP_001036333.1	WD40 repeat	90..124	CDD:293791	11/50 (22%)
		WD40 repeat	131..166	CDD:293791	7/44 (16%)
		WD40	135..493	CDD:295369	76/378 (20%)
		WD40	163..574	CDD:225201	94/459 (20%)
		WD40 repeat	174..217	CDD:293791	14/49 (29%)
		WD40 repeat	270..318	CDD:293791	7/47 (15%)
		WD40 repeat	323..370	CDD:293791	7/49 (14%)
		WD40 repeat	414..462	CDD:293791	12/48 (25%)
		WD40 repeat	468..511	CDD:293791	7/45 (16%)
Eml3	NP_659121.1	TD_EMAP3	6..>34	CDD:409270
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..210
		HELP	216..285	CDD:397490	13/64 (20%)
		WD 1	235..287		13/66 (20%)
		WD 2	296..345		10/48 (21%)
		WD40	300..626	CDD:421866	89/447 (20%)
		WD40 repeat	309..356	CDD:293791	9/49 (18%)
		WD 3	351..393		9/45 (20%)
		WD40 repeat	364..403	CDD:293791	6/38 (16%)
		WD 4	399..435		12/35 (34%)
		WD40 repeat	409..457	CDD:293791	14/48 (29%)
		WD 5	449..488		12/52 (23%)
		WD40 repeat	464..513	CDD:293791	15/75 (20%)
		WD 6	505..544		11/80 (14%)
		WD40 repeat	518..556	CDD:293791	11/79 (14%)
		WD 7	550..585		15/69 (22%)
		WD40	552..869	CDD:421866	80/446 (18%)
		WD40 repeat	562..596	CDD:293791	16/60 (27%)
		WD 8	590..627		7/44 (16%)
		WD40 repeat	601..635	CDD:293791	5/35 (14%)
		WD 9	630..668		10/46 (22%)
		WD40 repeat	643..678	CDD:293791	9/43 (21%)
		WD 10	675..710		6/34 (18%)
		WD40 repeat	684..724	CDD:293791	6/39 (15%)
		WD 11	717..756		12/85 (14%)
		WD40 repeat	730..756	CDD:293791	7/45 (16%)
		WD 12	766..824		16/80 (20%)
		WD40 repeat	799..837	CDD:293791	11/49 (22%)
		WD 13	831..870		7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	875..897		7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2106
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900