DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34124 and Eml3

DIOPT Version :9

Sequence 1:	NP_001036333.1	Gene:	CG34124 / 4379887	FlyBaseID:	FBgn0083960	Length:	2003	Species:	Drosophila melanogaster
Sequence 2:	XP_006231069.1	Gene:	Eml3 / 102551660	RGDID:	7630023	Length:	897	Species:	Rattus norvegicus

Alignment Length:	887	Identity:	169/887 - (19%)
Similarity:	274/887 - (30%)	Gaps:	351/887 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PRDIVSVEHSFGY---DCKKLFNLVLVDSDTLVFASGNFLNYFSISRQEISFQETVY--GC---- 80
            |.:.:|::..:||   |.:         |:..|..||                |.||  .|
  Rat   245 PSETLSLDWVYGYRGRDSR---------SNLFVLRSG----------------EVVYFIACVVVL 284

  Fly    81 -----------GVGFITKNEHPDYTNLFTVGENGAR-----------------PTVFIYEYPSLN 117
                       |.|......|.|......|..:|.|                 |.|.|::..:|.
  Rat   285 YRPGGGPGGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLQ 349

  Fly   118 VRVKLLNAAQNCFTAGSYNKTGELFASQAGYPDFI----------ITIWRWENAEVVLRAKSFQS 172
               ||.......|..|    .|.|..|.|....|:          :::|.......:...||...
  Rat   350 ---KLQEIGLGAFERG----VGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGVKLAEIKSTND 407

  Fly   173 DILFVHFSEHNPILLCSSGLSHIKFWKMANTFTGL-------KLKGDLGRFGKTDFSDIYAMYML 230
            .:|.|.||..:...:.:||.||:.||..:.. ||:       :.:|..|::.|..|  |.....|
  Rat   408 SVLAVGFSPRDSSCIVTSGKSHVHFWNWSGG-TGVPGNGILARKQGVFGKYKKPKF--IPCFVFL 469

  Fly   231 QDENVISGSDWGNMLLWQAGLIKFEICRKGRKPCHTKPITRITMKNGEVTTVGMDGYVRVWYWET 295
            .|.|:::|...||:|.|            ||....:|             |.|..|....  :..
  Rat   470 PDGNILTGDSEGNILTW------------GRSVSDSK-------------TPGRGGAKET--YTI 507

  Fly   296 VDLADPPEDDLFVEIDPIYEFKIADVELRCMQKIHPFDESDFTHYAQDG---NGGIWFCDINTYD 357
            |..|...|..:|.               .|:::              ||   :||
  Rat   508 VAQAHAHEGSIFA---------------LCLRR--------------DGTVLSGG---------- 533

  Fly   358 VPQKPRKLYSCIGGKVLAAQMSPVSPHFLCMSESGKLFVYQYDEQRLILEKEFPAEGVDVIWLDT 422
              .:.|:|... |..::|.|.:.:..||..:              |.|      |||:
  Rat   534 --GRDRRLVQW-GPGLVALQEAEIPEHFGAV--------------RAI------AEGL------- 568

  Fly   423 NISVKGTE-LVAAFKDGILRQMYLDLSNGERPKMTRVRAFKAHTSPITALTVSRNSSLLLTGSAD 486
                 |:| ||...|:.:||.   ||:.|..|      ..:.||..:..|......:..||...|
  Rat   569 -----GSELLVGTTKNALLRG---DLAQGFSP------VIQGHTDELWGLCTHPFQNRFLTCGHD 619

  Fly   487 KSIFIYQLSRDEHQM---VDMRPLGFVQFAAIPNCFYWHETEPTVVLVGCKSG-----DLYEYNI 543
            :.:.::  ..:.|.:   :|::..|.        |..:|.: ..||:||..:|     |.....|
  Rat   620 RQLCLW--DGEGHALAWSMDLKETGL--------CADFHPS-GAVVVVGLNTGRWLVLDTETREI 673

  Fly   544 RTEVTDHETYLS----------------------YNI----TENSR----MRHTKFASIKSRIRR 578
            .::|||....||                      |::    |::||    |.|:.|
  Rat   674 VSDVTDGNEQLSVVRYSPDGLYLAIGSHDNMIYIYSVSSCGTKSSRFGRCMGHSSF--------- 729

  Fly   579 DIHRENVKKRKERKRERKMNEVEKLKKANPGLQIDIESALADSEPDEEEEPLHIPTVPNAIIW-- 641
                              :..::..|..|     .|.|...|.|               .:.|
  Rat   730 ------------------ITHLDWSKDGN-----FIMSNSGDYE---------------ILYWDV 756

  Fly   642 --------LRYTLRDTIWVSMAGYDAGYIYELEFNAAEPTRATIIAEADDIEIHSYCIIDEFIIF 698
                    .||..||..|.:.......::|.:..:.::.|           :|:|.|
  Rat   757 AGGCKLLRNRYESRDREWATYTCVLGFHVYGVWPDGSDGT-----------DINSLC-------- 802

  Fly   699 GLHNGRIRINRINPDNFTDLSEFRIYP---------MHDGLKGTIPKIDISYSGEHLLTI-GYDG 753
            ..||.|:   ....|:|..:..|: ||         |:.|....:..:..::....|::: |.|.
  Rat   803 RSHNERV---VAVADDFCKVHLFQ-YPCARAKAPSRMYSGHGSHVTSVRFTHDDSFLVSLGGKDA 863

  Fly   754 NVFLHKWNGPKIVRNKVRDKLPPLPEGVTQIPDIEPEACSLE 795
            ::|  :|      |........|.|...::.|.:.| |.||:
  Rat   864 SIF--QW------RVLGAGSSGPAPATPSRTPSLSP-ASSLD 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34124	NP_001036333.1	WD40 repeat	90..124	CDD:293791	11/50 (22%)
		WD40 repeat	131..166	CDD:293791	7/44 (16%)
		WD40	135..493	CDD:295369	77/378 (20%)
		WD40	163..574	CDD:225201	95/459 (21%)
		WD40 repeat	174..217	CDD:293791	14/49 (29%)
		WD40 repeat	270..318	CDD:293791	7/47 (15%)
		WD40 repeat	323..370	CDD:293791	7/49 (14%)
		WD40 repeat	414..462	CDD:293791	12/48 (25%)
		WD40 repeat	468..511	CDD:293791	7/45 (16%)
Eml3	XP_006231069.1	HELP	216..285	CDD:281450	13/64 (20%)
		WD40	<299..626	CDD:225201	90/448 (20%)
		WD40	300..626	CDD:295369	90/447 (20%)
		WD40 repeat	309..355	CDD:293791	9/48 (19%)
		WD40 repeat	364..403	CDD:293791	6/38 (16%)
		WD40 repeat	409..457	CDD:293791	14/48 (29%)
		WD40 repeat	464..513	CDD:293791	16/75 (21%)
		WD40	514..872	CDD:225201	93/529 (18%)
		WD40 repeat	518..554	CDD:293791	11/77 (14%)
		WD40	552..869	CDD:295369	80/446 (18%)
		WD40 repeat	562..595	CDD:293791	16/59 (27%)
		WD40 repeat	644..679	CDD:293791	10/35 (29%)
		WD40 repeat	685..725	CDD:293791	5/39 (13%)
		WD40 repeat	730..766	CDD:293791	7/55 (13%)
		WD40 repeat	798..835	CDD:293791	11/48 (23%)
		WD40 repeat	843..870	CDD:293791	5/34 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2106
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900