DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG34124 and cfap44

DIOPT Version :10

Sequence 1:NP_001036333.1 Gene:CG34124 / 4379887 FlyBaseID:FBgn0083960 Length:2003 Species:Drosophila melanogaster
Sequence 2:XP_031752292.1 Gene:cfap44 / 100497083 XenbaseID:XB-GENE-6047484 Length:2333 Species:Xenopus tropicalis


Alignment Length:1814 Identity:487/1814 - (26%)
Similarity:837/1814 - (46%) Gaps:173/1814 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 DLLGEEEELENENDVS----FPRDIVSVEHSFGYDCKKLFNLVLVDSDTLVFASGNFLNYFSISR 68
            |...|.|.|.:...|:    .|..::.:.|||||||.|..||.|:|:.||::.:|......|:..
 Frog   595 DFYYEYESLRSGPYVTPNSGIPSGVLQLLHSFGYDCTKRANLHLLDNQTLLYVAGTTCVILSVKT 659

  Fly    69 QEISFQETVYGCGVGFITKNEHPDYTNLFTVGENGARPTVFIYEYPSLNVRVKLLNAAQNCFTAG 133
            ||..:..:..|.|:|.:|.:....|   |.|.|.|..|.:.||.||||.....|....:..:...
 Frog   660 QEQRYVRSSSGAGIGAVTVHPRKAY---FAVAEKGNAPNIIIYGYPSLKPYRILRGGTEEAYAFV 721

  Fly   134 SYNKTGELFASQAGYPDFIITIWRWENAEVVLRAKSFQSDILFVHFSEHNPILLCSSGLSHIKFW 198
            .:|.:|.|.||....||:.:|||.|....::||:|:|..|:..|.||..|...|.:.|..|||||
 Frog   722 DFNVSGTLLASVGSSPDYTLTIWDWRQENIMLRSKAFSQDVFQVTFSAENEEQLTTCGTGHIKFW 786

  Fly   199 KMANTFTGLKLKGDLGRFGKTDFSDIYAMYMLQDENVISGSDWGNMLLWQAGLIKFEICRKGRKP 263
            |||:|||||||:|:|||||||..|||.....|.|..|||||:|||||||:.||||.|:||||.:.
 Frog   787 KMASTFTGLKLQGELGRFGKTGLSDIEGYVELPDGKVISGSEWGNMLLWEGGLIKVELCRKGGRS 851

  Fly   264 CHTKPITRITMKNGEVTTVGMDGYVRVWYWETVDLADPPEDDLFVEIDPIYEFKIA-DVELRCMQ 327
            ||..||.:..:..||:.|:|.||:||||.:|.||.||..:|...:|::|:.|..:. :|.||.|.
 Frog   852 CHNGPINQFVLDEGELITIGSDGFVRVWDFEMVDTADTVDDSGLLEMEPMNELLVGRNVNLRFMV 916

  Fly   328 KIHPFDESDFTHYAQDGNGGIWFCDINTYDVPQKPRKLYSCIGGKVLAAQMSPVSPHFLCMSESG 392
            |  ..|......:|||.||.||..|::..::.|.|..|:|...|.:.|...||.:......|...
 Frog   917 K--ATDTEAPLWFAQDANGAIWKLDLSFSNITQDPECLFSFHAGNIKALDASPSTYLMATTSLDR 979

  Fly   393 KLFVYQYDEQRLILEKEFPAEGVDVIWLDTNISVKGTELVAAFKDGILRQMYLDLSNGER----- 452
            .:.:|.:..:..::|.:|...|..::|....::.||......|.||::|.:.:..|.|.|     
 Frog   980 SVRIYDFIGKYPLVEMKFKQGGTSLVWAPRMVNPKGGLFAVGFDDGVVRILEVHSSLGSRIVAGR 1044

  Fly   453 -----PKMTRVRAFKAHTSPITALTVSRNSSLLLTGSADKSIFIYQLSRDEHQMVDMRPLGFVQF 512
                 .::...:|||.|.:|:||||..||..:|.|||.|:::|.:.:. |.::     |:|||:.
 Frog  1045 PGKQEAELNLKQAFKPHRAPVTALTYERNGEILATGSMDRTVFFFTVG-DSYE-----PIGFVRV 1103

  Fly   513 AAIPNCFYW----HETEPTVVLVGCKSGDLYEYNIRTEVTDHETYLSYNITENSRMRHTKFASIK 573
            .......:|    ||....:||  |::|  :...|.....:....||.....:..:::.:|:|||
 Frog  1104 PGPVRELHWTPPSHEESHLLVL--CENG--FAVQIPAPSAEKRDPLSTFEIPDVPLKYFRFSSIK 1164

  Fly   574 SRIRRDIHRENVKKRKERKRERKMNE----VEKLKKANPGLQIDIESALADSEPDEEEEPLHIPT 634
            |:::|:   |.:.:|:::| |:|:.|    ::|.|:....|..|....||:.|.:|...||::|.
 Frog  1165 SKLQRE---EEIGRRQKQK-EQKLKEREAWIKKQKEQGVELTEDDLQGLAEEEEEEPLPPLYVPK 1225

  Fly   635 VPNAIIWLRYTLRDTIWVSMAGYDAGYIYELEFN------------AAEPTRATIIAEADDIEIH 687
            .|:.|:...|......|:|:.|||:|::|..||:            ..||.....:.:.....|:
 Frog  1226 DPSPILCGFYASPGKFWLSLDGYDSGFLYLCEFSDLQDQPEDLTSRRDEPLSVLPVEDTTSNPIY 1290

  Fly   688 SYCIID--EFIIFGLHNGRIRIN--RINPDNFTDLSEFRIYPMHDGLKGTIPKIDISYSGEHLLT 748
            .:....  :.:..|:.:|.:|:.  :.|....|.:..:....:||...|.:..|..||..::|:|
 Frog  1291 KFHFSSNKQLLFCGMRDGTVRVYPLQANDPLLTSMHGYWALGVHDNQYGRVQSISTSYDNQYLVT 1355

  Fly   749 IGYDGNVFLHKWNGPKIVRNKVRDKLPPLP------EGVTQIPDIE-PEACSLEQEKINAE---L 803
            .|.|.|:|.......:.:...::.....:|      |||..:.||| |.|.|:|..|...:   |
 Frog  1356 CGGDSNIFTFSILSMEEIERDLKGNKAKIPSPRNDTEGVRPVEDIEDPNAYSIEDAKQKRQQDLL 1420

  Fly   804 RRQQEAADAHDRDVLSKIGALQNVYFDIIRINEELPPGLRAKDTDLLLDDRITRQIRNELQAELD 868
            .||.|...:..|.:|::   |:..:..::..|..||..::....:..:|.||..::..:...::.
 Frog  1421 VRQAEEQKSQKRHLLAE---LRREFELLLGRNAALPGHMQLSREEFEMDQRIREEMERQTSEKIR 1482

  Fly   869 DVREDLAYDLEFAQVGHTKLYNHFLKELVQVPFTVAPL--RANVPGVSTFRLQALGEEHAQIKQD 931
            ....:||::.|...|...||...|...:.....||..:  |..||   |:|:..|.:.:.|.|..
 Frog  1483 TALRELAWEQEKHSVALRKLQARFRDNVECDTVTVRAISSRHQVP---TYRMLVLSDNYPQGKGT 1544

  Fly   932 IEDRLKREHDMGLHD-YVAPERSDESIGEPPPESFFFGRDPKSIEPRF----------------- 978
            :..|....||:.:.: ..|.|..|....||   |...|.  |.:|...                 
 Frog  1545 LMKRRPTRHDLRVKEGEAAKEPWDVGTAEP---SATLGE--KELEALMNQQKQKKQWVGRRHGGA 1604

  Fly   979 -SKKMMRLLTRYRKRQIFEVRRIFDWDKLERQKPDPNRNHPDDDAQIEDAKRNLGDFKLKIGSDY 1042
             :::|..::.:..|.:....:|..:|.:|.|:||..:...|:|...|:.||.|:|||.||...||
 Frog  1605 QAERMRNIMEKAEKAKSKIAQRKREWAELYRKKPSEDYEDPEDVTAIKRAKENMGDFNLKTSEDY 1669

  Fly  1043 EPKSSETLT--QKYIEVVECREQYFAMVDAFNQMVLDLRERKGELDQFITAKRNRLAVIHNYLPE 1105
            .......:.  :|..|:............|.|:.:|.||:.|....:.|.:....:..|.:.|..
 Frog  1670 TVPEHLRINAERKRKELAALEGTIHKQKSAMNRRILALRDLKESTIEQIQSLVTNVHHIQSMLDP 1734

  Fly  1106 PDRQPLDPIQEIDMDLEYPELNLIEHYTPGCGVEIDDILTLEHSVDQVIARM-------APMRST 1163
            .:..|:.|:..:..| |.||...  .|.                 ::.::|.       |..|..
 Frog  1735 SNHLPVPPVPTMHPD-ETPEKRF--QYN-----------------NKTLSRFRLEQESRARERQA 1779

  Fly  1164 ANVSLFSLHGLDVPELHEHTAFTMLQISKLNRSLPNAELDEELLKLPPKSDPAYFELNDDGQVPY 1228
            ...:.|...|.....:...|..|....|..:.|.|:        ..||...|.       |:...
 Frog  1780 GGANGFGGFGTQTTTVETTTDSTKSTGSTTHSSQPS--------PTPPPQMPM-------GETSK 1829

  Fly  1229 MME--TRHRWLRQLLVEQNAIRTEVDEEVRQFDKALEKLQVRRFHVKMDAEFMTAFMN--SLNQE 1289
            :.|  .|...::.|.::::.|: ::...|..||..|..|  |...:::|.|...|.:.  :|.:|
 Frog  1830 LEEEIRRTEEIKNLYLQEHLIQ-KIHTLVLDFDAELRIL--RHQKIQLDVEMKMADLRHITLFEE 1891

  Fly  1290 LYILRDSEEIETQLLLNAKTAMSTRNDLQMVINSTNRQLDELRRNIDKLGEQIVALQVLF-ATTV 1353
            |.:|::.|:.|..|.......::.:.::...:..:.:|||..:|.|.:|.|:..|:...| |:..
 Frog  1892 LLLLKEFEKREDTLQERVSERIAEKGEMTRRLEDSMQQLDTKKREIGRLQEKEKAIHSAFQASLG 1956

  Fly  1354 KGHKFFDFLRRIFKKKWRPPK-----VSRGDDESSSSSSSSSSSSEDEQADNKSLDSLDMTTIRL 1413
            :.:|...||.::|:||.:..|     .:..:::.|...|...|:.|.::..:.|.:.:      .
 Frog  1957 ENNKLATFLSKVFRKKIKRTKKKEEQAAEDEEDESEEESDEESAWESDEDGSGSEEGV------F 2015

  Fly  1414 DEATCPTGLDRSLYDLAFSMRSDRHDLERNVRELTREVENKRKEIAEMQIKMKFHEEVYQREKNA 1478
            |::.||...|.:|::....:|..|.|:|..:.|..:.|:|.:||...:..|:|..|....:.:..
 Frog  2016 DDSVCPNNCDPALFESTLQLREKRLDVEEALTEEKKIVDNLKKEYDSLSKKIKALELSLSQAEAE 2080

  Fly  1479 LLQFRRNRQQEVNKVHISAILRMDQLQHFYDGDDYRDLSKAILFDADMLVDLRRRADQLSEETLA 1543
            |..|:|.:|:::|::.:...|::.|:.:..:|:...|||:|::|....|..|::|..:|.:|.:.
 Frog  2081 LEAFQREKQRKLNELDVVVPLKLHQVDYLVNGEIPGDLSQALVFTNQSLESLQQRIRELQQEKVE 2145

  Fly  1544 TKRWHRINFIHLRRMNTDIKFMRFEITRLEEEIRQAMMKKFGIIVNLDELEEEVLRRYIFDLETN 1608
            .:..:|......:::..|.|.:..:|..|||...|.|::|||.||:|:.|:...:...:.:|:..
 Frog  2146 KRELYRQAREQHKQLIRDKKEVERKIKVLEERCSQQMLRKFGRIVDLEALQTLSVNTTLEELKIK 2210

  Fly  1609 AEDELMALEKELLEKQKELARCEEELVLETQNNTEKVNIMTVLREENNILRTLLD-IQNKNYAKW 1672
            :.:....::.||.|.::::...:..|:..|:..|.|:..|..|..|..:|.:.|| :|.....::
 Frog  2211 SSERAQRMDGELAEWEEKVTEAKRNLMEVTREQTRKLQKMNELLTEKKVLESKLDALQTAVGEEF 2275

  Fly  1673 ANPNALNLSYDIEKLRGIEKSLLDQIECLEREICALRLKSKPLQINYEFEVDPNAQPQV 1731
            ..|.... :.:.:||..:.:...::|..|:.||..|..|..        .:.|.|||.:
 Frog  2276 KGPRRAE-TKERQKLLHLVQMQTEEISNLKEEISLLSKKGG--------SILPPAQPPI 2325

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG34124NP_001036333.1 WD40 repeat 90..124 CDD:293791 13/33 (39%)
WD40 repeat 131..166 CDD:293791 11/34 (32%)
WD40 135..493 CDD:475233 148/368 (40%)
WD40 repeat 174..217 CDD:293791 25/42 (60%)
WD40 repeat 270..318 CDD:293791 19/47 (40%)
WD40 repeat 323..370 CDD:293791 17/46 (37%)
WD40 repeat 414..462 CDD:293791 12/57 (21%)
WD40 repeat 468..511 CDD:293791 16/42 (38%)
SMC_N <1435..>1631 CDD:481474 49/195 (25%)
cfap44XP_031752292.1 2A1904 <48..>299 CDD:273344
MSCRAMM_ClfA <180..496 CDD:468110
LGT <427..611 CDD:469786 5/15 (33%)
WD40 repeat 628..668 CDD:293791 14/39 (36%)
WD40 repeat 673..711 CDD:293791 14/40 (35%)
WD40 708..1086 CDD:441893 148/379 (39%)
WD40 repeat 719..754 CDD:293791 11/34 (32%)
WD40 repeat 762..798 CDD:293791 20/35 (57%)
WD40 repeat 806..854 CDD:293791 29/47 (62%)
WD40 repeat 960..994 CDD:293791 5/33 (15%)
WD40 repeat 1002..1053 CDD:293791 10/50 (20%)
WD40 repeat 1065..1099 CDD:293791 14/39 (36%)
WD40 <1286..>1363 CDD:475233 17/76 (22%)
PTZ00121 <1374..>1684 CDD:173412 76/320 (24%)
Smc <2032..>2312 CDD:440809 69/280 (25%)
Blue background indicates that the domain is not in the aligned region.

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