Protein Alignment lobo and DRC7

DIOPT Version :10

• Sequence 1: NP_001036757.1
• Gene: lobo / 4379864
• FlyBaseID: FBgn0083946
• Length: 897
• Species: Drosophila melanogaster
• Sequence 2: NP_115645.4
• Gene: DRC7 / 84229
• HGNCID: 25289
• Length: 874
• Species: Homo sapiens
• Alignment Length: 915
• Identity: 270/915 - (29%)
• Similarity: 442/915 - (48%)
• Gaps: 112/915 - (12%)

  Fly    24 KFKEIDEQRRSQGSE-SDFA--DEMEGEFEAEMEEMGSSEFSLSEGEPSLNIGKIDLS--FPE-T 82
            |.:|.:|..|.:.:| :::|  ::|....|...||:...:.:|.:.|..|:..:|.:|  .|. |
Human     7 KVEEEEEAEREEAAEWAEWARMEKMMRPVEVRKEEITLKQETLRDLEKKLSEIQITVSAELPAFT 71

  Fly    83 VEEFENSPQCYPPSYYTLSPKERLLLLYAENFRKQLVLSYPKRRAMVLALPNECKVQKFVCTTIR 147
            .:..:.|.  .|.||.|.:|||..||..|:||.:|.....|.|..:.|...|||:|.|||.||:|
Human    72 KDTIDISK--LPISYKTNTPKEEHLLQVADNFSRQYSHLCPDRVPLFLHPLNECEVPKFVSTTLR 134

  Fly   148 PTAFIYTQLISSVEEIAKFVADFIQYEPLQDPINLPNRLISPETLLRKRKGNSYEMATLLVSMLI 212
            ||...|.:|. :.:..|:||:||:...||.||:..|:.|.|..|:|:.:|||.::.:|||.||||
Human   135 PTLMPYPELY-NWDSCAQFVSDFLTMVPLPDPLKPPSHLYSSTTVLKYQKGNCFDFSTLLCSMLI 198

  Fly   213 GAGHPALVVSGVAREETILNDQLAVPYPYPIVEVEV----EEVKPKVEKPGQKYKLRGLPDLKSH 273
            |:|:.|..|:|....:....|......|..:...|.    |:|.||      ||.::...||.|.
Human   199 GSGYDAYCVNGYGSLDLCHMDLTREVCPLTVKPKETIKKEEKVLPK------KYTIKPPRDLCSR 257

  Fly   274 LEEDMAEVHRQKE---AEEKRIQDEIIRKQMEDLELLAVDRYHYRRSHAWVVIINNAPWSVKPKT 335
            .|::. ||.:|:|   .|:||:::|  .:::.:.|....|..|..|.|:||::::..
Human   258 FEQEQ-EVKKQQEIRAQEKKRLREE--EERLMEAEKAKPDALHGLRVHSWVLVLSGK-------- 311

  Fly   336 TYTDVNGDVVEAPPTAIFIEPSTGFICETGCKQYILVDSIWNEYNYYV--------CKQKHQRVS 392
                      ...|...||:|.||....|..:.::.::|:||..||::        ||
Human   312 ----------REVPENFFIDPFTGHSYSTQDEHFLGIESLWNHKNYWINMQDCWNCCK------- 359

  Fly   393 ELRWDLRDTKDWEHMLPGEPPEMRIYKMASDENVADEERDI------SEEKHLDCIGSWVERLHI 451
            :|.:||.|...||:||.|............|..:.||: |:      .|:|..|...||||::.|
Human   360 DLIFDLGDPVRWEYMLLGTDKSQLSLTEEDDSGINDED-DVENLGKEDEDKSFDMPHSWVEQIEI 423

  Fly   452 GLADFEQRFPSSEKKIQYKGAIHERFSPYSQRDGKVMQLTIFNNDECT-IPKVRYEYYENRSDL- 514
            ....||.|.|:.:|.||||.|..|:::||...:|.|.:||.:.:.:|| |.::: |:|:||.|:
Human   424 SPEAFETRCPNGKKVIQYKRAKLEKWAPYLNSNGLVSRLTTYEDLQCTNILEIK-EWYQNREDML 487

  Fly   515 -MRHVKYTYATDQFEEIFNKGRNDSLKSIEYFS-DPSQQRKVHFFSASRIDSLELMVVEPGSLIL 577
             ::|:..|  ||...:.|..|...:|:...|.| .|...|.:.|:..:|:|.|......|.::..
Human   488 ELKHINKT--TDLKTDYFKPGHPQALRVHSYKSMQPEMDRVIEFYETARVDGLMKREETPRTMTE 550

  Fly   578 HYKDRSDKCWYKEFEFTPAGNVLK------------KVTEKFLKASANDVCSNDIATRTFLFQQN 630
            :|:.|.|...|:...|.|....|.            |:||:|.:..|.. ...|:|.|.||..:.
Human   551 YYQGRPDFLSYRHASFGPRVKKLTLSSAESNPRPIVKITERFFRNPAKP-AEEDVAERVFLVAEE 614

  Fly   631 KIVLKFHYTFGALTATVVEFTKPPRPD-YGKELIYDEKLTKIYKANPLDPTRTNLELYRLLCEQL 694
            :|.|::|.....:||:..||.:....| .|.::|....:...::..|::.|:..|..|..:. .|
Human   615 RIQLRYHCREDHITASKREFLRRTEVDSKGNKIIMTPDMCISFEVEPMEHTKKLLYQYEAMM-HL 678

  Fly   695 QYEDHLRKNFEKIFE---DINNVFDLRKSEKAEPKLKFSIFDPLRNGAARAIR--MRQFEEEEEL 754
            :.|:.|.::  :::|   ::..:..||:.|:|...|..||:|..||..::..|  |.:...||.|
Human   679 KREEKLSRH--QVWESELEVLEILKLREEEEAAHTLTISIYDTKRNEKSKEYREAMERMMHEEHL 741

  Fly   755 KKEIASKPADFLAPYLVPYKHQEELTPEQSQNAYNACLNDLKSRFVSLLNNLQRHYEDLTSESKS 819
            ::  .....|:|||:|......|:||..|:....:.||:|.|.|.::..|.:|..:|..|.|.:.
Human   742 RQ--VETQLDYLAPFLAQLPPGEKLTCWQAVRLKDECLSDFKQRLINKANLIQARFEKETQELQK 804

  Fly   820 LNRFLNKFENQFNNYDYKRLVQQSKDLELNK--------RMVQQRLTLTHEESQKKYEVVKNSLL 876
            ..::..  |||..      |..:.:||.|:.        |:::|||....|.:..||..::..|.
Human   805 KQQWYQ--ENQVT------LTPEDEDLYLSYCSQAMFRIRILEQRLNRHKELAPLKYLALEEKLY 861

  Fly   877 KDPRL 881
            |||||
Human   862 KDPRL 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lobo	NP_001036757.1	YebA	<160..228	CDD:440916	29/67 (43%)
DRC7	NP_115645.4	Transglut_core	<173..>214	CDD:450180	18/40 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..410		5/24 (21%)