DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lobo and drc7

DIOPT Version :9

Sequence 1:	NP_001036757.1	Gene:	lobo / 4379864	FlyBaseID:	FBgn0083946	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001072331.1	Gene:	drc7 / 779784	XenbaseID:	XB-GENE-959992	Length:	856	Species:	Xenopus tropicalis

Alignment Length:	904	Identity:	260/904 - (28%)
Similarity:	416/904 - (46%)	Gaps:	113/904 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FKEIDEQRRSQGSESDFADEMEGEFEAEMEEMGS--SEFSLSEGEPSLNIGKIDLSFPETVEEFE 87
            |:|.|::|    .|....|..|.....|:.:|..  |:..||..:.:..|.::.|...|.
Frog    12 FEEEDKER----EEDQVLDSDEVLDSNELNDMQECLSQTDLSNIDNNRAIQQLSLGSMEF----- 67

  Fly    88 NSPQCYPPSYYTLSPKERLLLLYAENFRKQLVLSYPKRRAMVLALPNECKVQKFVCTTIRPTAFI 152
                   |||.|.|.||.:||..|:||..|....||.|:.:.:...|||.|:||||||:.||...
Frog    68 -------PSYTTNSEKEEMLLGLADNFWHQYTHLYPDRKPLFMCPRNECGVEKFVCTTLHPTLLP 125

  Fly   153 YTQLISSVEEIAKFVADFIQYEPLQDPINLPNRLISPETLLRKRKGNSYEMATLLVSMLIGAGHP 217
            |:.|. ..::.||||::::..|||..|:.||..|.|..::|:|:.||.::.:.||.|:|:|||:.
Frog   126 YSDLY-DWDQSAKFVSEYLTMEPLNPPLELPRSLFSSTSVLQKQSGNCFDFSVLLCSLLLGAGYD 189

  Fly   218 ALVVSGVAREETILNDQLAVPYPYPIVEVEVEEVKPKV-EKPGQKYKLRGLPDLKSHL------- 274
            |..|||.|..|..|.|:.....|   :..:|||...:: :||.:||.::....|.|..
Frog   190 AYCVSGYATREMCLMDEKRNICP---LLNKVEESSWEIPQKPLKKYTVKPPRQLISKFAVQQEAK 251

  Fly   275 -EEDMAEVHRQKEAEEKRIQDEIIRKQMEDLELLAVDRYHYRRSHAWVVIINNAPWSVKPKTTYT 338
             :..|.|..|.::.||.|::        ||.|....|..|..|.|.||::::..
Frog   252 KQAKMEEALRNEQEEETRLK--------EDAEKPGPDNLHGLRVHCWVLVLSGK----------- 297

  Fly   339 DVNGDVVEAPPTAIFIEPSTGFICETGCKQYILVDSIWNEYNYYV--------CKQKHQRVSELR 395
                   ...|...||:..||....|..:.::.|:|:||..:|:|        ||       :::
Frog   298 -------REVPENFFIDALTGKSYATISEPFLGVESVWNHEDYWVNMQDCRNGCK-------DMK 348

  Fly   396 WDLRDTKDWEHMLPGEPPEMRIYKMASDENVADEERDISEEKHL-DCIGSWVERLHIGLADFEQR 459
            :||.|...||::|.|....:.:.....||...:.| .|.|.|.: ....|||..:.|...:||.|
Frog   349 FDLGDPVCWEYLLQGGSKPLLLIPDEEDEEELNGE-TIQENKTIFQMPPSWVLPIVIRPKEFETR 412

  Fly   460 FPSSEKKIQYKGAIHERFSPYSQRDGKVMQLTIFNNDECTIPKVRYEYYENRS---DLMRHVKYT 521
            .|...|.:|||.|.||:::||.:|||.|.:||.:.:.|||......:.::||.   ||....|..
Frog   413 CPQGRKILQYKKAKHEKWAPYLKRDGHVSRLTGYLDTECTQEVKIQDCFQNRKDKLDLREQNKIE 477

  Fly   522 YATDQFEEIFNKGRNDSLKSIEYFS-DPSQQRKVHFFSASRIDSLELMVVEPGSLILHYKDRSDK 585
            ..|.::   |..||.||||..||.| .|..:|.:.|:|.:|:|.|:....:|..:...|:.|:|.
Frog   478 QVTTEY---FIPGRADSLKVHEYRSLAPETERSMMFYSEARLDGLQRRDEKPVEMTEIYQGRADF 539

  Fly   586 CWYKEFEF-------------TPAG-NVLKKVTEKFLKASANDVCSNDIATRTFLFQQNKIVLKF 636
            .:|:...|             |.|. ..:.|:||:| ..:.....:.|:|.||||..:::|.|:.
Frog   540 LYYRHIVFGKRPKKVAIAGGPTEANPRPILKITERF-NRNKEKPANEDVAERTFLLTEDRIQLRC 603

  Fly   637 HYTFGALTATVVEFTKPPRPDYGKELIYDEKLTKI---------YKANPLDPTRTNLELYRLLCE 692
            |.....:|.:..||.||..        ..||.|.|         |:..|.:.....|.:|..|..
Frog   604 HRKDDHITTSYWEFLKPAN--------LGEKDTPIVLTPETCISYQVEPSEKFSKQLYVYETLVT 660

  Fly   693 QLQYEDHLRKNFEKIFEDINNVFDLRKSEKAEPKLKFSIFDPLRNGAARAIRMRQFEEEEELKKE 757
            ..|.|.:.:.|..|...::..:...|..|:|:|:|..||:|..||..::..|.......:|.::.
Frog   661 LQQAEQNSKDNVRKSETEVREILATRAQEEADPQLTISIYDTERNEKSKEKREAMERAIQEERQR 725

  Fly   758 IASKPADFLAPYLVPYKHQEELTPEQSQNAYNACLNDLKSRFVSLLNNLQRHYEDLTSESKSLNR 822
            .|.:..|:|||:|......|:||..|:|.....||:|:|.|.:...|.:|..:|..|.|.:...:
Frog   726 RAVQELDYLAPFLAQLGDPEKLTLWQAQKVKEDCLSDMKQRLIEKANLIQARFEKETQELQKKQQ 790

  Fly   823 FLNKFENQFNNYDYKRLVQQSKDLELNKRMVQQRLTLTHEESQKKYEVVKNSLLKDPRL 881
            :.::.:...:..|.:..:....:......:::.||....:.:.:||..:::.|.|||||
Frog   791 WYHQNQMSMSKEDEEAYLDYCSEAMFRIHILETRLNRHKDLAPQKYLALEDRLNKDPRL 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lobo	NP_001036757.1	Transglut_core	154..>228	CDD:280085	29/73 (40%)
drc7	NP_001072331.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		6/21 (29%)
		Transglut_core	<160..>196	CDD:376628	15/35 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..277		9/29 (31%)
		COG4372	<662..>821	CDD:226809	38/158 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2526
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12996
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2420
OMA	1	1.010	-	-		QHG56449
OrthoDB	1	1.010	-	-		D228301at33208
OrthoFinder	1	1.000	-	-		FOG0008380
OrthoInspector	1	1.000	-	-		oto104014
Panther	1	1.100	-	-	LDO	PTHR35249
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4500
SonicParanoid	1	1.000	-	-		X6367
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110