DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lobo and ccdc135

DIOPT Version :9

Sequence 1:	NP_001036757.1	Gene:	lobo / 4379864	FlyBaseID:	FBgn0083946	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	XP_009296199.1	Gene:	ccdc135 / 555782	ZFINID:	ZDB-GENE-120406-10	Length:	843	Species:	Danio rerio

Alignment Length:	885	Identity:	253/885 - (28%)
Similarity:	415/885 - (46%)	Gaps:	98/885 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 EMEGEFEAEM----EEMGSSEFSLSEGEPSLNIGKIDLS-------FPETVEEFENSPQCYPPSY 97
            |||.|.:|.:    |:.|..|.     |.||| ..|.|:       .|.|..:...    ||.||
Zfish     6 EMESEEDATLTDDEEKKGFREL-----ESSLN-NNIRLTPDLPHIMKPRTPVDLSR----YPSSY 60

  Fly    98 YTLSPKERLLLLYAENFRKQLVLSYPKRRAMVLALPNECKVQKFVCTTIRPTAFIYTQLISSVEE 162
            ...|.:|.|:|..|||||:|.||.||.|:|::|:..|||.|||||.||:|.:...|.:|. ..|.
Zfish    61 KQNSSQETLMLAMAENFRQQFVLLYPDRKALLLSPVNECGVQKFVSTTLRSSLLPYPELY-DWEG 124

  Fly   163 IAKFVADFIQYEPLQDPINLPNRLISPETLLRKRKGNSYEMATLLVSMLIGAGHPALVVSGVARE 227
            .|.||:|::..|.|..|..||.:|.||..:|:.::|..:|.:.:|.|:|:|||..|..|||.|.:
Zfish   125 CASFVSDYLSLELLDPPFELPKQLSSPTRVLQTQRGTCFEFSMVLCSLLLGAGFNAYCVSGYATK 189

  Fly   228 ETILNDQLAVPYPY--PIVEVEVEEVKPKVEKPGQKYKLRGLPDLKSHLEEDMAEVHRQK---EA 287
            |..|.||.....|.  |..:...||.|..|    .||.::...||.|..|:...|..:.|   :|
Zfish   190 EMCLLDQSRQECPLLKPPKQDNTEEPKKTV----NKYSVKPPRDLYSTFEKHQEEKQQAKVKADA 250

  Fly   288 EEKRIQDEIIRKQME----DLELLAVDRYHYRRSHAWVVIINNAPWSVKPKTTYTDVNGDVVEAP 348
            .:|:.::|.:||:.|    | .||.:      |.|:||::::.:                  ...
Zfish   251 VKKQQEEERLRKEQERPPHD-PLLGL------RIHSWVLVLSGS------------------REI 290

  Fly   349 PTAIFIEPSTGFICETGCKQYILVDSIWNEYNYYVCKQKHQ-RVSELRWDLRDTKDWEHMLPG-- 410
            |...||:|.||....|..:.::.::||||..||:|.||... ....:.:||.|...||:||.|
Zfish   291 PENFFIDPLTGKGYSTTNENFVGIESIWNHQNYWVNKQDCSFGCGSMTFDLGDLSKWEYMLCGLT 355

  Fly   411 -EPPEMRIYKMASDENVADEERDISEEKHLDCIGSWVERLHIGLADFEQRFPSSEKKIQYKGAIH 474
             :...|...:.:..|...:||.:|.|.|..:...|||.::.|...|.|.|:|...|.:||:.|..
Zfish   356 SQSISMISEQKSPREPEDEEEEEIDELKAFEMPTSWVTKIDIPPPDMEMRYPGGSKILQYRKAKL 420

  Fly   475 ERFSPYSQRDGKVMQLTIFNNDECTIPKVRYEYYENRSDLMRHVKYTYATDQFEEIFNKGRNDSL 539
            |:|:||..:||.|.:||.:.:.|||.|....|::::|||.:...:....::...|.|..||:|:|
Zfish   421 EKFAPYLLKDGLVTKLTTYKDLECTQPNTIKEWFKHRSDHLEERELHTDSNVTTEHFRPGRSDAL 485

  Fly   540 KSIEYFS-DPSQQRKVHFFSASRIDSLELMVVEPGSLILHYKDRSDKCWY------KEFEFTPAG 597
            |...|.: .|..:|::.|:..:..|.|...:.:...:...::||:|..:|      |:.:...||
Zfish   486 KYHRYVTLVPETERQMDFYGHTCTDGLARRIEKQSEMTETFEDRTDFLYYRHIVYGKQIKVIRAG 550

  Fly   598 NVL-----KKVTEKFLKASANDVCSNDIATRTFLFQQNKIVLKFHYTFGALTATVVEFTKPPR-- 655
            ..|     |.|.|:|.: ..:...|.|:|.|.|.....||.:.:|.....:....:.|.||..
Zfish   551 EALNQRPIKSVEERFHR-DPSKPASKDVAERNFKMSDGKIQVTYHLEDDRIIPAWMNFIKPKAAA 614

  Fly   656 -----PDYGKELIYDEKLTKIYKANPLDPTRTNLELYRLLCEQLQYEDHLRKNFEKIFEDINNVF 715
                 .|:..|::..      ::.:|......:|:||::|.|.::.|:::........:::.::.
Zfish   615 NSQKGQDFSPEMVSG------FQVDPFAKPYNDLQLYKILLELMRDEENVELQIRNSEKEVKSIL 673

  Fly   716 DLRKSEKAEPKLKFSIFDPLRNGAARAIRMRQFEEEE----ELKKEIASKPADFLAPYLVPYKHQ 776
            ..|:.|.:...|..||::..||..||    |..||:|    |.:|....|..|.|||:....:..
Zfish   674 SSREKEDSNTDLLISIYNTTRNETAR----RHMEEKERKAKEKQKRQKEKELDLLAPFQARLEQT 734

  Fly   777 EELTPEQSQNAYNACLNDLKSRFVSLLNNLQRHYEDLTSESKSLNRFLNKFENQFNNYDYKRLVQ 841
            |.||.:.:......||.:.|.:..:..|.:|..:|..|.|.:....:..|.:...:..|.:...:
Zfish   735 ESLTLKDALQLKRDCLTEFKQQLANKANLIQGRFEKETEELQKKQLWYQKNQLTMSTEDEEDYFK 799

  Fly   842 QSKDLELNKRMVQQRLTLTHEESQKKYEVVKNSLLKDPRL 881
            ...:......:::.||:...|.:.::|..::.:|.:.|:|
Zfish   800 YCSEAMFRIHVLKLRLSRQKERAPQRYLALEETLKRHPKL 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lobo	NP_001036757.1	Transglut_core	154..>228	CDD:280085	28/73 (38%)
ccdc135	XP_009296199.1	Transglut_core	<150..>186	CDD:307794	14/35 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I2714
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12996
Inparanoid	1	1.050	318	1.000	Inparanoid score	I2515
OMA	1	1.010	-	-		QHG56449
OrthoDB	1	1.010	-	-		D228301at33208
OrthoFinder	1	1.000	-	-		FOG0008380
OrthoInspector	1	1.000	-	-		oto39073
orthoMCL	1	0.900	-	-		OOG6_103795
Panther	1	1.100	-	-	LDO	PTHR35249
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4500
SonicParanoid	1	1.000	-	-		X6367
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010