DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lobo and Drc7

DIOPT Version :9

Sequence 1:	NP_001036757.1	Gene:	lobo / 4379864	FlyBaseID:	FBgn0083946	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001036180.2	Gene:	Drc7 / 330830	MGIID:	2685616	Length:	876	Species:	Mus musculus

Alignment Length:	909	Identity:	268/909 - (29%)
Similarity:	428/909 - (47%)	Gaps:	116/909 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 DEMEGEFEAEMEEMG--------------SSEFS-----LSEGEPSLNIGKI-DLSFPETVEE-- 85
            :::|.|.|||.||..              |:|.|     ||:.|.....||: .:..|...:.
Mouse     6 EKVEEEEEAEREEAAERAERTEKLERVTKSAEVSREGTILSQDELRDLEGKLMAIEIPTQADHSV 70

  Fly    86 FENSP---QCYPPSYYTLSPKERLLLLYAENFRKQLVLSYPKRRAMVLALPNECKVQKFVCTTIR 147
            ...:|   ...||||.|.|.||..|||.|:||.:|.....|.|..:.|...|||.|.|||.||:|
Mouse    71 ISQAPVDVTKLPPSYTTNSLKEEHLLLVADNFSRQYSHLCPDRVPLFLHPLNECNVPKFVSTTLR 135

  Fly   148 PTAFIYTQLISSVEEIAKFVADFIQYEPLQDPINLPNRLISPETLLRKRKGNSYEMATLLVSMLI 212
            ||...|.:|. :.:..|:||:||:...||.||:..|..|.|..|:|:.:|||.::.:|||.||||
Mouse   136 PTLMPYPELY-NWDSCAQFVSDFLTMVPLVDPLKPPTHLYSSTTVLKCQKGNCFDFSTLLCSMLI 199

  Fly   213 GAGHPALVVSGVAREETILNDQLAVPYPYPIVEVEVEEVKPKVEKPGQKYKLRGLPDLKSHLEED 277
            |:|:.|..|:|....:..|.|......|..:...|:  ||.|.:...:||.::...||.|..|::
Mouse   200 GSGYDAYCVNGYGSLDLCLMDLTREVCPLTVKAKEI--VKKKEKTVPKKYSIKPPRDLTSKFEQE 262

  Fly   278 MAE--VHRQKEAEEKRIQDEIIRKQMEDLELLAVDRYHYRRSHAWVVIINNAPWSVKPKTTYTDV 340
            ..|  :...|:.|::|:::|  ..::.:.|....|..|..|.|:||:::...
Mouse   263 QEEKRIQEIKDLEQRRLKEE--EDRILEAEKAKPDPLHGLRVHSWVLVLAGK------------- 312

  Fly   341 NGDVVEAPPTAIFIEPSTGFICETGCKQYILVDSIWNEYNYYV--------CKQKHQRVSELRWD 397
                 ...|.:.||:|.|.....|..:.::.::|:||..||::        ||       :|.:|
Mouse   313 -----REVPESFFIDPLTARSYSTKDEHFLGIESLWNHKNYWINMQDCWNCCK-------DLIFD 365

  Fly   398 LRDTKDWEHMLPG-EPPEMRIYKMASDENVADEERDI------SEEKHLDCIGSWVERLHIGLAD 455
            |.|...||:||.| :.|.:.:.: ..:|.:.|::.|:      .|:|..|...|||.::.|...:
Mouse   366 LGDPVRWEYMLLGTDKPHLSLTE-EDEEGLDDDDDDVEDLGKEEEDKSFDMPSSWVSQIEITPEE 429

  Fly   456 FEQRFPSSEKKIQYKGAIHERFSPYSQRDGKVMQLTIFNNDECTIPKVRYEYYENRSDL--MRHV 518
            ||.|.||.:|.||||.|..|::|||...:|.|.:||.:.:.:||......|:|:||.|:  ::|:
Mouse   430 FETRCPSGKKVIQYKKAQLEKWSPYLNNNGLVCRLTTYEDQQCTKVLEIKEWYQNREDMLELKHI 494

  Fly   519 KYTYATDQFEEIFNKGRNDSLKSIEYFSD-PSQQRKVHFFSASRIDSLELMVVEPGSLILHYKDR 582
            ..|  |....:.|..|...:|....|.|. |...|.:.|:...|:|.|......|.::..:|:.|
Mouse   495 NKT--TGLHVDYFKPGHPQALCVHSYKSMLPEMDRVMEFYKKIRVDGLVKREETPMTMTEYYEGR 557

  Fly   583 SDKCWYKEFEFTPAGNVLK------------KVTEKFLKASANDVCSNDIATRTFLFQQNKIVLK 635
            ||...|:...|.|....|.            |:||:|.: :.......|:|.|.||..:.:|.|:
Mouse   558 SDFLAYRHVNFGPRVKKLSQSSVESNPRPMVKITERFSR-NPEKPADEDVAERLFLIVEERIQLR 621

  Fly   636 FHYTFGALTATVVEFTKPPRPD-YGKELIYDEKLTKIYKANPLDPTRTNLELYRLLCEQLQYEDH 699
            :|.....:||:..||.:....| .|.::|...::...|:..|::.|:..|..|..: .||:.|:.
Mouse   622 YHCRDDYITASKREFLRRMEVDSKGNKIIMTPEMCISYEVEPMEHTKKLLYQYETM-NQLKNEEK 685

  Fly   700 LRKN--FEKIFEDINNVFDLRKSEKAEPKLKFSIFDPLRNGAARAIR--MRQFEEEEELKKEIAS 760
            |.::  :|...| :..:..||:.|:....|..||:|..||..::..|  |.:...||.|::..|.
Mouse   686 LSRHQAWESELE-VLEILKLREEEEEAHTLTISIYDTKRNEKSKEYREAMERVLHEEHLRQVEAQ 749

  Fly   761 KPADFLAPYLVPYKHQEELTPEQSQNAYNACLNDLKSRFVSLLNNLQRHYEDLTSESKSLNRFLN 825
              .|:|||:|......|:||..|:....:.||:|.|.|.:...|.:|..:|..|.|.:...::..
Mouse   750 --LDYLAPFLAQLPPGEKLTRWQAVRLKDECLSDFKQRLIDKANLIQARFEKETQELQKKQQWYQ 812

  Fly   826 KFENQFNNYDYKRLVQQSKDLELNK--------RMVQQRLTLTHEESQKKYEVVKNSLLKDPRL 881
              |||..      |..:.::|.|:.        |:::|||....|.:..||..::..|.|||||
Mouse   813 --ENQVT------LTPEDENLYLSYCSQAMFRIRILEQRLNRHKELAPLKYLALEEKLYKDPRL 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lobo	NP_001036757.1	Transglut_core	154..>228	CDD:280085	30/73 (41%)
Drc7	NP_001036180.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		9/33 (27%)
		Transglut_core	<174..>215	CDD:376628	18/40 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..412		4/27 (15%)
		PRK10246	<688..>851	CDD:182330	47/173 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2519
eggNOG	1	0.900	-	-		E1_28JA6
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12996
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2471
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56449
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008380
OrthoInspector	1	1.000	-	-		oto93789
orthoMCL	1	0.900	-	-		OOG6_103795
Panther	1	1.100	-	-	LDO	PTHR35249
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4500
SonicParanoid	1	1.000	-	-		X6367
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.860