DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lobo and Drc7

DIOPT Version :9

Sequence 1:	NP_001036757.1	Gene:	lobo / 4379864	FlyBaseID:	FBgn0083946	Length:	897	Species:	Drosophila melanogaster
Sequence 2:	NP_001099639.1	Gene:	Drc7 / 291853	RGDID:	1565601	Length:	874	Species:	Rattus norvegicus

Alignment Length:	922	Identity:	278/922 - (30%)
Similarity:	437/922 - (47%)	Gaps:	126/922 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KFKEIDEQRRSQGSE-SDFADEMEGEFEA-EMEEMG--SSEFSLSEGEPSLNIGKIDLSFPETVE 84
            |.:|.:|..|.:.:| ::.|::.|...:| |:.:.|  .|:..|.:.|..|.  .|::..|.
  Rat     7 KVEEEEEAEREEAAERAERAEKAERVLKATEVSKEGIILSQDDLRDLEEKLM--AIEIPTPA--- 66

  Fly    85 EFENSPQC--------YPPSYYTLSPKERLLLLYAENFRKQLVLSYPKRRAMVLALPNECKVQKF 141
              ::|..|        .||||.|.|.||..|||.|:||.:|.....|.|..:.|...|||.|.||
  Rat    67 --DHSVICQVPVDVTKLPPSYTTNSLKEEHLLLVADNFSRQYSHLCPDRVPLFLHPLNECNVPKF 129

  Fly   142 VCTTIRPTAFIYTQLISSVEEIAKFVADFIQYEPLQDPINLPNRLISPETLLRKRKGNSYEMATL 206
            |.||:|||...|.:|. :.:..|:||:||:...||.||:..|..|.|..|:|:.:|||.::.:||
  Rat   130 VSTTLRPTLMPYPELY-NWDSCAQFVSDFLTMVPLVDPLKPPTHLYSSTTVLQCQKGNCFDFSTL 193

  Fly   207 LVSMLIGAGHPALVVSGVAREETILNDQLAVPYPYPIVEVEVEEVKPKVEKPG-QKYKLRGLPDL 270
            |.|||||:|:.|..|:|....:..|.|......|   :.|:.:|:..|.||.. :||.::...||
  Rat   194 LCSMLIGSGYDAYCVNGYGSLDLCLMDLTREVCP---LTVKAKEIVAKKEKVAPKKYAVKPPRDL 255

  Fly   271 KSHLEEDMAEVHRQ--KEAEEKRIQDEIIRKQMEDLELLAVDRYHYRRSHAWVVIINNAPWSVKP 333
            .|..|::..|...|  |:.|.||:::|  .:::.:.|....|..|..|.|:||::::..
  Rat   256 TSRFEQEQEEKRLQAIKDQELKRLKEE--EERLLEAEKAKPDPLHGLRVHSWVLVLSGK------ 312

  Fly   334 KTTYTDVNGDVVEAPPTAIFIEPSTGFICETGCKQYILVDSIWNEYNYYV--------CKQKHQR 390
                        ...|.:.||:|.||....|....::.::|:||..||::        ||
  Rat   313 ------------REVPESFFIDPFTGRSYGTKDDHFLGIESLWNHKNYWINMQDCWNCCK----- 360

  Fly   391 VSELRWDLRDTKDWEHMLPG-EPPEMRIYKMASDENVADEERD----ISEEKHLDCIGSWVERLH 450
              :|.:||.|...||:||.| :.|.:.:.. ..||.:.|:|.:    ..|:|..|...|||.::.
  Rat   361 --DLIFDLGDPVRWEYMLLGTDKPHLSLTD-DDDEGLDDDEDEDQGKEEEDKSFDMPPSWVAQIE 422

  Fly   451 IGLADFEQRFPSSEKKIQYKGAIHERFSPYSQRDGKVMQLTIFNNDECTIPKVRYEYYENRSDL- 514
            |...:||.|.||.:|.||||.|..|::|||...:|.|.:||.:.:.:||......|:|:||.|:
  Rat   423 ITPEEFETRCPSGKKVIQYKKAQLEKWSPYLNNNGLVCRLTTYEDLQCTKVLEIKEWYQNREDML 487

  Fly   515 -MRHVKYTYATDQFEEIFNKGRNDSLKSIEYFSD-PSQQRKVHFFSASRIDSLELMVVEPGSLIL 577
             ::|:..|  |....:.|..|...:|....|.|. |...|.:.|:...|:|.|......|.::..
  Rat   488 ELKHINKT--TGLHVDYFKPGHPQALCVHSYKSMLPEMDRVMEFYKMIRVDGLVKREETPMTMTE 550

  Fly   578 HYKDRSDKCWYKEFEFTPAGNVLK------------KVTEKFLKASANDVCSNDIATRTFLFQQN 630
            :|:.|||...|:...|.|....|.            |:||:|.: :.......|:|.|.||..:.
  Rat   551 YYQGRSDFLSYRHINFGPRVKKLTQNSADSNPRPVVKITEQFFR-NPEKPADEDVAERVFLIAEE 614

  Fly   631 KIVLKFHYTFGALTATVVEFTKPPRPD-YGKELIYDEKLTKIYKANPLDPTRTNLELYRLLCEQL 694
            :|.|::|.....:||...||.:....| .|.::|...::...|:..|::.|:      :||   .
  Rat   615 RIQLRYHCRDDYITANKREFLRRTEVDSKGNKIIMTPEMCISYEVEPMEHTK------KLL---Y 670

  Fly   695 QYED--HLRKNFEKIFE--------DINNVFDLRKSEKAEPKLKFSIFDPLRNGAARAIR--MRQ 747
            |||.  || ||.||:..        ::..:..||:.|:....|..||:|..||..::..|  |.:
  Rat   671 QYETMIHL-KNEEKLSRHQAWESELEVLEILKLREEEEEAHTLTISIYDTKRNEKSKEYREAMER 734

  Fly   748 FEEEEELKKEIASKPADFLAPYLVPYKHQEELTPEQSQNAYNACLNDLKSRFVSLLNNLQRHYED 812
            ...||.|::..|.  .|:|||:|......|:||..|:....:.||:|.|.|.:...|.:|..:|.
  Rat   735 VLHEEHLRQVEAQ--LDYLAPFLAQLPPGEKLTRWQAVRLKDECLSDFKQRLIDKANLIQARFEK 797

  Fly   813 LTSESKSLNRFLNKFENQFNNYDYKRLVQQSKDLELNK--------RMVQQRLTLTHEESQKKYE 869
            .|.|.:...::..  |||..      |..:.:||.|:.        |:::|||....|.:..||.
  Rat   798 ETQELQKKQQWYQ--ENQVT------LTPEDEDLYLSYCSQAMFRIRILEQRLNRHKELAPLKYL 854

  Fly   870 VVKNSLLKDPRL 881
            .::..|.|||||
  Rat   855 ALEEKLYKDPRL 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lobo	NP_001036757.1	Transglut_core	154..>228	CDD:280085	30/73 (41%)
Drc7	NP_001099639.1	Transglut_core	<174..>211	CDD:280085	17/36 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I2494
eggNOG	1	0.900	-	-		E1_28JA6
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12996
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2433
OMA	1	1.010	-	-		QHG56449
OrthoDB	1	1.010	-	-		D228301at33208
OrthoFinder	1	1.000	-	-		FOG0008380
OrthoInspector	1	1.000	-	-		oto97328
orthoMCL	1	0.900	-	-		OOG6_103795
Panther	1	1.100	-	-	LDO	PTHR35249
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6367
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840