DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-VI and nphs1

DIOPT Version :9

Sequence 1:	NP_001036705.1	Gene:	side-VI / 4379854	FlyBaseID:	FBgn0083950	Length:	1087	Species:	Drosophila melanogaster
Sequence 2:	NP_001035777.1	Gene:	nphs1 / 692352	ZFINID:	ZDB-GENE-051102-1	Length:	1242	Species:	Danio rerio

Alignment Length:	991	Identity:	212/991 - (21%)
Similarity:	336/991 - (33%)	Gaps:	338/991 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 THKEPAELIINPVKEKDAG-NFRCRVDFKLSQTRNSNV---NLEVVVPPTQ-------PIIFNER 153
            |||         |..:|.| :.:|....|  .||.|:|   .|.|..||.:       |.:|
Zfish   394 THK---------VSREDNGLSLQCEAFNK--GTRFSSVRAAELIVYYPPQKVWLDAPPPNVF--- 444

  Fly   154 RLRIDSRAGPYEEGGSLEVTCVVYGGSPPPTVIWLMNGQLQNSVVDYTYDGAINSKLVVRNLSR- 217
                      ...|.:|.:.|...||:|...:.||.|    |.|| .|....::|:   |.:||
Zfish   445 ----------LHSGSTLRLVCFSSGGNPTGQLTWLKN----NKVV-LTASKQVSSE---RGVSRE 491

  Fly   218 ----IHQH---AVYTCQASNFHKKYVATNITIDLYLRPLLVEISFNNQPMSADRKYEIECQAIGS 275
                :|..   |.|.|.:||..||.::......:....:.|:|....:.:...:..:::|.|..|
Zfish   492 LLLTLHPSDNLATYRCDSSNKAKKVLSAQTKFRVLFPAVSVKIVAKQKELRRGQTLDLDCLAGSS 556

  Fly   276 RPPAKITWWMGNLELHGHSQ--KVSEDGNVS-TSVLSITPTREDHGKALSCRATNELVRNGIRET 337
            .|.|.|:|.:|.:.|.|..|  |.:|.|.:| ||.||:|.......|.::|:|.:.::..|: ..
Zfish   557 NPTANISWSLGPVILKGVDQAPKRAEFGGMSRTSKLSLTLEPHHWRKRITCQAFSNVLSEGV-NN 620

  Fly   338 AMKLNVFFIP----------------TLQLDLGSNLNPEDI------------------------ 362
            ...|:|.|.|                |..|....:.||::|
Zfish   621 FYSLDVLFPPEFSAEQPDEVQVIEDETATLPAKVSANPDEITCEWIFQGEKLVKERDPRYTFSDW 685

  Fly   363 ---------EEGDDVYFECK----------------------------------------VHANP 378
                     .:|.|...||.                                        ..|||
Zfish   686 TLEIVNVSRRDGGDYIIECSNAEGSNRTKLRLDVQYSPTVRMKSDPVFVNIGDTADLLCVADANP 750

  Fly   379 AAYKVV-WK-----HNHQIIQHNQRAGVIVSSGDLALQGVTRHQAGNYTCTASN-------VEGD 430
            ....:. ||     ...::.:.::..|    :|.|.:..|||.:||.|.|||.|       |||
Zfish   751 ITSSMFSWKWMGEGERDELGEESEDDG----TGVLTIYEVTRDRAGVYQCTADNGISPTGSVEG- 810

  Fly   431 GDSNVVELKVMYKPICR--PDQKKI--YGVARNEAAEIVCEVDAFPPPENFKWSFNNTAETFDMP 491
                  :|.|.:.|..:  |..:|:  .|...|: |.:||:....|..: |:|:.|.    |.:.
Zfish   811 ------QLIVRFAPDLQKGPQWRKVASRGDGSND-ANVVCQAQGVPRVQ-FRWAKNG----FPLD 863

  Fly   492 QSGFRPHSAQGSTLT-YTPV-------KEMDFGTIMCWADNNVGQQKEPCVFHLIAAGKPEAPTN 548
            ....|......||.| :|.:       ..:|:....|.|.|::|:  :.....|::...|:.|::
Zfish   864 LGNPRYEETTESTGTIHTSILTVINVSAALDYAIFTCTAHNSMGE--DSLDIQLLSTNHPDPPSD 926

  Fly   549 CTV--VNQTSDSLEVYCIEGFDGGMRQWFLMEIFDQHSGQLQANISAKF----------AALSVT 601
            ..:  |:|||.:||  .:.|||||:.|.|.:..  |.:|      ||.:          ...:||
Zfish   927 LKLLRVDQTSVTLE--WMPGFDGGLTQIFRVRY--QWAG------SASYMYVDVFPPTATVYTVT 981

  Fly   602 GLDAGRLFRIYVYAVNGRGRS--------------DAIALDGYTLKAAEKQTVA---LTSYKGSA 649
            ||:...::...|.|:|..|.|              ||...||....|.:...:|   |..|
Zfish   982 GLNPSTMYNFSVNALNSIGESSYADNNKILTVTTADAKEADGGVSTADQDSALAGGGLPVY---- 1042

  Fly   650 QSPDNFELTPILSIGIFVGILVAIVCIGIGTIAALKLRSHKHQQQQKFVHPNAKFSRPGNLQIKD 714
                   :..||.:|..:.:|...:|.   .:|..|.|.                |..||.
Zfish  1043 -------VVVILVVGGVLFLLNPFICF---LLARWKRRR----------------SLKGNT---- 1077

  Fly   715 KISLPLSHSEEMYDEKNPDVVPYNEVDGEYKQKSATQTPSGHLSTTSEVEISCKPGSTSGTGIVQ 779
                                   :.:..|.|.:....|.|......|...|:   .|...|.:|.
Zfish  1078 -----------------------SSISQETKSEEQRSTASSSTRYASRELIN---ASAQRTLLVD 1116

  Fly   780 ANS-ADSGTYQS-SKDDELHYAELSLTNMPSGSSGASKKGQPMG--------GVGVVQHVVQQQQ 834
            ::| .||..|:| .:.:..||      ..|:.:...:....|.|        |.....||.::.:
Zfish  1117 SSSEPDSSVYESYGRQENPHY------YYPTEAYSPALYAHPEGPEDCDGRHGTSPFTHVYEEVR 1175

  Fly   835 QQQQGQVQHPHQLLGGTLPHGSSMRKLLPTIPATATLQRHKPNAGGMQHPHQHAPPPTYDYD--Y 897
            ...:                  .::...|..||.              |.|..||..|| |:  .
Zfish  1176 GMYE------------------DLQACSPLPPAA--------------HIHPQAPFSTY-YEGRA 1207

  Fly   898 FEEPTIYAQIDAYKTM 913
            :.:..:...|.||.:|
Zfish  1208 YSKADVDVTIGAYDSM 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VI	NP_001036705.1	IG_like	35..140	CDD:214653	13/43 (30%)
		Ig_3	157..230	CDD:290638	21/80 (26%)
		IG_like	165..242	CDD:214653	25/84 (30%)
		Ig	265..343	CDD:299845	25/80 (31%)
		IG_like	267..343	CDD:214653	25/78 (32%)
		IG_like	363..440	CDD:214653	26/129 (20%)
		IGc2	364..429	CDD:197706	23/117 (20%)
		IG_like	456..532	CDD:214653	19/83 (23%)
		Ig_3	456..524	CDD:290638	17/75 (23%)
		fn3	545..622	CDD:278470	26/88 (30%)
nphs1	NP_001035777.1	IG_like	33..126	CDD:214653
		Ig	133..216	CDD:386229
		Ig	261..313	CDD:386229
		Ig	333..419	CDD:386229	10/35 (29%)
		ig	439..511	CDD:365836	23/92 (25%)
		IG_like	637..719	CDD:214653	9/81 (11%)
		Ig_3	723..800	CDD:372822	17/80 (21%)
		Ig_hNephrin_like	814..922	CDD:143250	25/115 (22%)
		FN3	921..1012	CDD:238020	28/100 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810