Protein Alignment side-VI and nphs1

DIOPT Version :10

• Sequence 1: NP_001036705.1
• Gene: side-VI / 4379854
• FlyBaseID: FBgn0083950
• Length: 1087
• Species: Drosophila melanogaster
• Sequence 2: XP_073779348.1
• Gene: nphs1 / 692352
• ZFINID: ZDB-GENE-051102-1
• Length: 1287
• Species: Danio rerio
• Alignment Length: 925
• Identity: 203/925 - (21%)
• Similarity: 325/925 - (35%)
• Gaps: 309/925 - (33%)

  Fly   100 THKEPAELIINPVKEKDAG-NFRCRVDFKLSQTRNSNV---NLEVVVPPTQ-------PIIFNER 153
            |||         |..:|.| :.:|....|  .||.|:|   .|.|..||.:       |.:|
Zfish   439 THK---------VSREDNGLSLQCEAFNK--GTRFSSVRAAELIVYYPPQKVWLDAPPPNVF--- 489

  Fly   154 RLRIDSRAGPYEEGGSLEVTCVVYGGSPPPTVIWLMNGQLQNSVVDYTYDGAINSKLVVRNLSR- 217
                      ...|.:|.:.|...||:|...:.||.|    |.|| .|....::|:   |.:||
Zfish   490 ----------LHSGSTLRLVCFSSGGNPTGQLTWLKN----NKVV-LTASKQVSSE---RGVSRE 536

  Fly   218 ----IHQH---AVYTCQASNFHKKYVATNITIDLYLRPLLVEISFNNQPMSADRKYEIECQAIGS 275
                :|..   |.|.|.:||..||.::|.....:....:.|:|....:.:...:..:::|.|..|
Zfish   537 LLLILHPSDNLATYRCDSSNKAKKVLSTQTKFRVLFPAVSVKIVAKQKELRRGQTLDLDCLAGSS 601

  Fly   276 RPPAKITWWMGNLELHGHSQ--KVSEDGNVS-TSVLSITPTREDHGKALSCRATNELVRNGIRET 337
            .|.|.|:|.:|.:.|.|..|  |.:|.|.:| ||.||:|.......|.::|:|.:.::..|: ..
Zfish   602 NPTANISWSLGPVILKGVDQAPKRAEFGGMSRTSKLSLTLESHHWRKRITCQAFSNVLSEGV-NN 665

  Fly   338 AMKLNVFFIP----------------TLQLDLGSNLNPEDI------------------------ 362
            ...|:|.|.|                |..|....:.||::|
Zfish   666 FYSLDVLFPPEFSDEQPDEVQVIEDETATLPAKVSANPDEITCEWIFQGEKLVKERDPRYTFSDW 730

  Fly   363 ---------EEGDDVYFECK----------------------------------------VHANP 378
                     .:|.|...||.                                        ..|||
Zfish   731 TLEIVNVSRRDGGDYIIECSNAEGSNRTKLRLDVQYSPTVRMKSDPVFVNIGDTADLLCVADANP 795

  Fly   379 AAYKVV-WK-----HNHQIIQHNQRAGVIVSSGDLALQGVTRHQAGNYTCTASN-------VEGD 430
            ....:. ||     ...::.:.::..|    :|.|.:..|||.:||.|.|||.|       |||
Zfish   796 ITSSMFSWKWMGEGERDELGEESEDDG----TGVLTIYEVTRDRAGVYQCTADNGISPTGSVEG- 855

  Fly   431 GDSNVVELKVMYKPICR--PDQKKI--YGVARNEAAEIVCEVDAFPPPENFKWSFNNTAETFDMP 491
                  :|.|.:.|..:  |..:|:  .|...|: |.:||:....|..: |:|:.|.    |.:.
Zfish   856 ------QLIVRFAPDLQKGPQWRKVASRGDGSND-ANVVCQAQGVPRVQ-FRWAKNG----FPLD 908

  Fly   492 QSGFRPHSAQGSTLT-YTPV-------KEMDFGTIMCWADNNVGQQKEPCVFHLIAAGKPEAPTN 548
            ....|......||.| :|.:       ..:|:....|.|.|::|:  :.....|::...|:.|::
Zfish   909 LGNPRYEETTESTGTIHTSILTVINVSAALDYAIFTCTAHNSMGE--DSLDIQLLSTNHPDPPSD 971

  Fly   549 CTV--VNQTSDSLEVYCIEGFDGGMRQWFLMEIFDQHSGQLQANISAKF----------AALSVT 601
            ..:  |:|||.:||  .:.|||||:.|.|.:..  |.:|      ||.:          ...:||
Zfish   972 LKLLRVDQTSVTLE--WMPGFDGGLTQIFRVRY--QWAG------SASYMYVDVFPPTATVYTVT 1026

  Fly   602 GLDAGRLFRIYVYAVNGRGRS--------------DAIALDGYTLKAAEKQTVA---LTSYKGSA 649
            ||:...::...|.|:|..|.|              ||...||....|.:...:|   |..|
Zfish  1027 GLNPSTMYNFSVNALNSIGESSYADNNKILMVTTADAKEADGGVSTADQDSALAGGGLPVY---- 1087

  Fly   650 QSPDNFELTPILSIGIFVGILVAIVCIGIGTIAALKLR------------SHKHQQQQKFVHPNA 702
                   :..||.:|..:.:|...:|.   .:|..|.|            ..|.::|:.....:.
Zfish  1088 -------VVVILVVGGVLFLLNPFICF---LLARWKRRRSLKGDTSSISQETKSEEQRSTASSST 1142

  Fly   703 KFSRPGNLQ-------IKDKISLP---------------------------LSHSE--EMYDEK- 730
            :::....:.       :.|..|.|                           .:|.|  |.||.:
Zfish  1143 RYASRELINASAQRTLLVDSSSEPDSSVYESYGRQENPHYYYPTEAYSPALYAHPEGPEDYDGRH 1207

  Fly   731 --NPDVVPYNEVDGEYK--QKSATQTPSGHLSTTSEVEISCKPGSTSGTG--------IVQANSA 783
              :|....|.||.|.|:  |..:...|:.|:...:       |.||...|        .|...:.
Zfish  1208 GTSPFTHVYEEVRGMYEDLQACSPLPPAAHIHPQA-------PFSTYYEGRAYSKADVDVTIGAY 1265

  Fly   784 DSGTYQSSKDDELHY 798
            ||..|:..:|.:|.:
Zfish  1266 DSMVYRRRRDTDLPF 1280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
side-VI	NP_001036705.1	IG_like	35..140	CDD:214653	13/43 (30%)
		Ig_3	165..230	CDD:464046	21/72 (29%)
		Ig	262..343	CDD:472250	25/83 (30%)
		Ig strand B	266..270	CDD:409416	0/3 (0%)
		Ig strand C	280..284	CDD:409416	1/3 (33%)
		Ig strand F	320..325	CDD:409416	1/4 (25%)
		Ig strand G	336..339	CDD:409416	0/2 (0%)
		Ig_3	358..426	CDD:464046	24/146 (16%)
		Ig_3	456..524	CDD:464046	17/75 (23%)
		FN3	545..622	CDD:473895	26/88 (30%)
nphs1	XP_073779348.1	None