DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-VI and Nphs1

DIOPT Version :9

Sequence 1:	NP_001036705.1	Gene:	side-VI / 4379854	FlyBaseID:	FBgn0083950	Length:	1087	Species:	Drosophila melanogaster
Sequence 2:	NP_072150.1	Gene:	Nphs1 / 64563	RGDID:	620460	Length:	1252	Species:	Rattus norvegicus

Alignment Length:	921	Identity:	184/921 - (19%)
Similarity:	311/921 - (33%)	Gaps:	276/921 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFTGPILICLIMGAITHANSHEHADGFKPDGEILRVLVNSSAQIKCDVGSSQADDKVLLVVWY- 64
            :..|.|.....|:|:::.:.                   |.:..:.|...||:  .:|||..|.
  Rat   348 LQVTFPPSAITILGSVSQSE-------------------NKNVTLCCLTKSSR--PRVLLRWWLG 391

  Fly    65 -KNNLPIYSYDTRGAHAGTPSHWRDEEVLEDRAVFRTHKEPAELIINPVKEKDAGNFRCRVDFKL 128
             :..||.......|.|.|        .:......|...:|...|.:......||.:   :..||.
  Rat   392 GRQLLPTDETVMDGLHGG--------HISMSNLTFLVRREDNGLPLTCEAFSDAFS---KETFKK 445

  Fly   129 SQTRNSNVNLEVVVPPTQPIIFNERRLRIDSRAGPYE-----EGGSLEVTCVVYGGSPPPTVIWL 188
            |.|.|       |..|.|       :|.|:   ||.|     .|..:.:.|:..||:|.|::||.
  Rat   446 SLTLN-------VKYPAQ-------KLWIE---GPPEGQYIRTGTRVRLVCLAIGGNPDPSLIWF 493

  Fly   189 MN------------------GQLQNSVVDYTYDGAINSKLVVRNLSRIHQHAVYTCQASNFHKKY 235
            .:                  |.::.|       |:..|:.:|..:......|.::|:|....
  Rat   494 KDSRPVSEPRQPQEPRRVQLGSVEKS-------GSTFSRELVLIIGPPDNRAKFSCKAGQLS--- 548

  Fly   236 VATNITIDLYLRPLLVEISFNNQPMSADRKYEIECQAIGSRPPAKITWWMGNLELH---GHSQKV 297
            .:|.:.:.  ..|..:.|..|:..:.......:.|.:|.|.||..::|......|.   ...|..
  Rat   549 ASTQLVVQ--FPPTNLTILANSSALRPGDALNLTCVSISSNPPVNLSWDKEGERLEDVAAKPQSA 611

  Fly   298 SEDGNVSTSVLSITPTREDHGKALSCRATNELVRNGIRETAMKLNVFFIPTLQLDLGSNLNPEDI 362
            ...|:.::..:.:..:..|||:.::|||.:|.:|..: .:..:.||.:.|..   ||..:....:
  Rat   612 PFKGSAASRSVFLRVSSRDHGQRVTCRAHSEALRETV-SSFYRFNVLYPPEF---LGEQVRAVTV 672

  Fly   363 EEGDDVYFECKVHANPAAYKVVWK-HNHQIIQHNQRAGVIVSSGDLALQGVTRHQAGNYTCTASN 426
            .|...|.....|.||||.....|. ..:::.........|:|.|.|.|..|||...|.|.....|
  Rat   673 VEQGQVLLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSGGALQLWNVTRADDGFYQLHCQN 737

  Fly   427 VEGDGDSNVVELKVMYKPICR----PDQKKIYGVARNEAAEIVCEVDAFP-PPENFKW------- 479
            .||..:: :::|.|.|.|..|    |.:..:.|     :.:|||.|||.| .||.|.|
  Rat   738 SEGTAEA-LLKLDVHYAPTIRALRDPTEVNVGG-----SVDIVCTVDANPILPEMFSWERLGEEE 796

  Fly   480 -----------SFNNTA----ETFDMPQSG-----------------------FRPHSAQGSTLT 506
                       |..:|.    ....:.|:|                       |.|...|.:.||
  Rat   797 EDLNLDDMEKVSKGSTGRLRIRQAKLSQAGAYQCIVDNGVAPAARGLVRLVVRFAPQVDQPTPLT 861

  Fly   507 -----------------------------------------YTPVK------------------E 512
                                                     ||..:                  .
  Rat   862 KVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHRYHQGVVHSSLLTIANVSAA 926

  Fly   513 MDFGTIMCWADNNVGQQKEPCVFHLIAAGKPEAPTNCTVVNQTSDSLEVYCIEGFDGGMRQWFLM 577
            .|:....|.|.|.:|  .:.....|::..:|:.|....||:.:..|:.:....|||||:.|.|.:
  Rat   927 QDYALFKCTATNALG--SDHTNIQLVSISRPDPPLGLKVVSISPHSVGLEWKPGFDGGLPQRFQI 989

  Fly   578 EIFD--QHSGQLQANI-SAKFAALSVTGLDAGRLFRIYVYAVNGRGRSDAIALDGYTLKAAEKQT 639
            . ::  :..|.|..:: ..:....::|||.....:||::.|.|..|.|      |.|.|..:
  Rat   990 R-YEALETPGFLHVDVLPTQATTFTLTGLKPSTRYRIWLLASNALGDS------GLTDKGIQ--- 1044

  Fly   640 VALTSYKGSAQSPDNFE------------LTPILSIGIFVGILVAI---VCIGIGTIAALKLRSH 689
            |::|: .|..|:|::.:            ..|:|.:...||.|:.:   .|:| |.:...:||
  Rat  1045 VSVTT-PGPDQAPEDTDHQLPTELPPGPPRLPLLPVLFAVGGLLLLSNASCVG-GLLWRRRLR-- 1105

  Fly   690 KHQQQQKFVHPNAKFSRPGNLQIKDKISLPLSHSEEMYDEKNPDVVPYNEVDGEYKQKSATQTPS 754
                                     :::..:|...|...|        :.:..||::...|....
  Rat  1106 -------------------------RLAEEISEKTEAGSE--------DRIRNEYEESQWTGDRD 1137

  Fly   755 GHLSTTSEVEI 765
            ...||.|..|:
  Rat  1138 TRSSTVSTAEV 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VI	NP_001036705.1	IG_like	35..140	CDD:214653	23/106 (22%)
		Ig_3	157..230	CDD:290638	20/95 (21%)
		IG_like	165..242	CDD:214653	18/99 (18%)
		Ig	265..343	CDD:299845	17/80 (21%)
		IG_like	267..343	CDD:214653	17/78 (22%)
		IG_like	363..440	CDD:214653	22/77 (29%)
		IGc2	364..429	CDD:197706	19/65 (29%)
		IG_like	456..532	CDD:214653	27/180 (15%)
		Ig_3	456..524	CDD:290638	25/172 (15%)
		fn3	545..622	CDD:278470	21/79 (27%)
Nphs1	NP_072150.1	Ig	52..128	CDD:299845
		IG_like	52..127	CDD:214653
		C2-set_2	155..242	CDD:285423
		Ig_3	256..335	CDD:290638
		IG_like	268..350	CDD:214653	0/1 (0%)
		C2-set_2	358..440	CDD:285423	20/113 (18%)
		I-set	460..555	CDD:254352	21/107 (20%)
		Ig	472..555	CDD:299845	17/92 (18%)
		Ig	563..646	CDD:299845	18/82 (22%)
		IG_like	670..750	CDD:214653	22/80 (28%)
		Ig	676..750	CDD:299845	21/74 (28%)
		Ig_3	753..834	CDD:290638	19/85 (22%)
		IG_like	762..848	CDD:214653	17/90 (19%)
		Ig	848..956	CDD:299845	13/109 (12%)
		IG_like	859..949	CDD:214653	9/91 (10%)
		FN3	955..1049	CDD:238020	27/103 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1043..1067		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1113..1144		7/38 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810