Protein Alignment side-VI and CEACAM1

DIOPT Version :10

• Sequence 1: NP_001036705.1
• Gene: side-VI / 4379854
• FlyBaseID: FBgn0083950
• Length: 1087
• Species: Drosophila melanogaster
• Sequence 2: NP_001703.2
• Gene: CEACAM1 / 634
• HGNCID: 1814
• Length: 526
• Species: Homo sapiens
• Alignment Length: 346
• Identity: 85/346 - (24%)
• Similarity: 143/346 - (41%)
• Gaps: 50/346 - (14%)

  Fly   207 NSKLVVRNLSRIHQHAVYTCQASNFHKKYVATNITIDLYLRPLLVE--ISFNNQPMSADRKYEIE 269
            |:.|:::|::: :....||.|.  .....|....|...::.|.|.:  ||.||.....|:    :
Human   104 NASLLIQNVTQ-NDTGFYTLQV--IKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDK----D 161

  Fly   270 CQAIGSRPPAKIT---WWMGNLELHGHSQKVSEDGNVSTSVLSITPTREDHGKALSCRATNELVR 331
            ..|....|..:.|   ||:.|..|....:....:||.:.::||:  ||.|.| ...|...|.:..
Human   162 AVAFTCEPETQDTTYLWWINNQSLPVSPRLQLSNGNRTLTLLSV--TRNDTG-PYECEIQNPVSA 223

  Fly   332 NGIRETAMKLNVFFIPTLQLDLGSNLNPED--IEEGDDVYFECKVHANPAAYKVVWKHNHQIIQH 394
            |  |...:.|||.:.|..     ..::|.|  ...|.::...|...:||.| :..|..|....|.
Human   224 N--RSDPVTLNVTYGPDT-----PTISPSDTYYRPGANLSLSCYAASNPPA-QYSWLINGTFQQS 280

  Fly   395 NQRAGVIVSSGDLALQGVTRHQAGNYTCTASN-VEGDGDSN-----VVELK-VMYKPICRPDQKK 452
            .|         :|.:..:|.:.:|:|||.|:| |.|...:.     |.||. |:.||..:..:..
Human   281 TQ---------ELFIPNITVNNSGSYTCHANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASKTT 336

  Fly   453 IYGVARNEAAEIVCEVDAFPPPENFKWSFNNTAETFDMPQSGFRPHSAQGSTLTYTPVKEMDFGT 517
            :.|  ..::..:.|..:  ....:.:|.|.|.:    :|.|.....|...:||:..|||..|.||
Human   337 VTG--DKDSVNLTCSTN--DTGISIRWFFKNQS----LPSSERMKLSQGNTTLSINPVKREDAGT 393

  Fly   518 IMCWADNNVGQ-QKEPCVFHL 537
            ..|...|.:.: |.:|.:.::
Human   394 YWCEVFNPISKNQSDPIMLNV 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
side-VI	NP_001036705.1	IG_like	35..140	CDD:214653
		Ig_3	165..230	CDD:464046	6/22 (27%)
		Ig	262..343	CDD:472250	21/83 (25%)
		Ig strand B	266..270	CDD:409416	0/3 (0%)
		Ig strand C	280..284	CDD:409416	1/6 (17%)
		Ig strand F	320..325	CDD:409416	1/4 (25%)
		Ig strand G	336..339	CDD:409416	0/2 (0%)
		Ig_3	358..426	CDD:464046	18/69 (26%)
		Ig_3	456..524	CDD:464046	16/67 (24%)
		FN3	545..622	CDD:473895
CEACAM1	NP_001703.2	IgV_CEACAM_D1	36..140	CDD:409430	8/38 (21%)
		FR1	37..55	CDD:409430
		Ig strand A	37..39	CDD:409430
		Required for homophilic binding. /evidence=ECO:0000250|UniProtKB:P16573	39..142		8/40 (20%)
		Ig strand A'	44..46	CDD:409430
		Ig strand B	49..56	CDD:409430
		CDR1	56..63	CDD:409430
		FR2	64..69	CDD:409430
		Ig strand C	64..68	CDD:409430
		CDR2	70..91	CDD:409430
		Ig strand C'	78..83	CDD:409430
		Ig strand C'	88..91	CDD:409430
		FR3	98..124	CDD:409430	5/20 (25%)
		Ig strand D	98..103	CDD:409430
		Ig strand E	105..109	CDD:409430	1/3 (33%)
		Ig strand F	119..124	CDD:409430	2/4 (50%)
		CDR3	125..132	CDD:409430	1/6 (17%)
		FR4	133..140	CDD:409430	1/6 (17%)
		Ig strand G	133..139	CDD:409430	1/5 (20%)
		IgI_hCEACAM_2_4_6_like	146..233	CDD:409402	25/95 (26%)
		Ig strand A	146..150	CDD:409402	0/3 (0%)
		Ig strand A'	153..158	CDD:409402	1/4 (25%)
		Ig strand B	163..169	CDD:409402	1/5 (20%)
		Ig strand C	176..181	CDD:409402	2/4 (50%)
		Ig strand C'	183..186	CDD:409402	0/2 (0%)
		Ig strand D	190..194	CDD:409402	0/3 (0%)
		Ig strand E	197..202	CDD:409402	1/4 (25%)
		Ig strand F	212..220	CDD:409402	1/7 (14%)
		Ig strand G	224..233	CDD:409402	3/10 (30%)
		IgC2_CEACAM5-like	243..318	CDD:409540	21/84 (25%)
		Ig strand A	243..249	CDD:409540	2/5 (40%)
		Ig strand B	254..261	CDD:409540	1/6 (17%)
		Ig strand C	267..273	CDD:409540	2/6 (33%)
		Ig strand C'	276..281	CDD:409540	1/4 (25%)
		Ig strand E	284..290	CDD:409540	1/5 (20%)
		Ig strand F	293..304	CDD:409540	5/10 (50%)
		Ig strand G	307..318	CDD:409540	1/10 (10%)
		Ig	327..415	CDD:472250	22/96 (23%)
		Ig strand B	344..348	CDD:409353	0/3 (0%)
		Ig strand C	357..361	CDD:409353	1/3 (33%)
		Ig strand E	379..383	CDD:409353	2/3 (67%)
		Ig strand F	393..398	CDD:409353	2/4 (50%)
		Ig strand G	408..411	CDD:409353	1/2 (50%)
		Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:P16573	450..462
		Interaction with FLNA. /evidence=ECO:0000250|UniProtKB:P16573	452..526
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..513
		Required for interaction with PTPN11 and PTPN6 and for control of phosphorylation level. /evidence=ECO:0000250|UniProtKB:P31809	489..526
		Essential for interaction with PTPN11 and PTPN6. /evidence=ECO:0000250|UniProtKB:P31809	520..523