DRSC/TRiP Functional Genomics Resources

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Protein Alignment side-VI and Nphs1

DIOPT Version :9

Sequence 1:NP_001036705.1 Gene:side-VI / 4379854 FlyBaseID:FBgn0083950 Length:1087 Species:Drosophila melanogaster
Sequence 2:NP_062332.2 Gene:Nphs1 / 54631 MGIID:1859637 Length:1256 Species:Mus musculus


Alignment Length:1074 Identity:207/1074 - (19%)
Similarity:340/1074 - (31%) Gaps:394/1074 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 NSSAQIKCDVGSSQADDKVLLVVWY--KNNLPIYSYDTRGAHAGTPSHWRDEEVLEDRAVFRTHK 102
            |.:..:.|...||:  .:|||..|.  :..||.......|.|.|                   |.
Mouse   368 NKNVTLCCLTKSSR--PRVLLRWWLGGRQLLPTDETVMDGLHGG-------------------HI 411

  Fly   103 EPAELIINPVKEKDAG-NFRCRV--DFKLSQTRNSNVNLEVVVPPTQPIIFNERRLRIDSRAGPY 164
            ..:.|.: .||.:|.| :..|..  |....:|...::.|.|..|        .::|.|:   ||.
Mouse   412 SMSNLTL-LVKREDNGLSLTCEAFSDAFSKETFKKSLTLNVKYP--------AQKLWIE---GPP 464

  Fly   165 E-----EGGSLEVTCVVYGGSPPPTVIWLMN------------------GQLQNSVVDYTYDGAI 206
            |     .|..:.:.|:..||:|.|::.||.:                  |.::.|       |:.
Mouse   465 EGQSIRTGTRVRLVCLAIGGNPEPSLTWLKDSRPVNDPRQSQEPRRVQLGSVEKS-------GST 522

  Fly   207 NSKLVVRNLSRIHQHAVYTCQASNFHKKYVATNITIDLYLRPLLVEISFNNQPMSADRKYEIECQ 271
            .|:.:|..:......|.::|:|....   .:|.:.:.  ..|..:.|..|:..:.......:.|.
Mouse   523 FSRELVLIIGPPDNLAKFSCKAGQLS---ASTQLVVQ--FPPTNLTILANSSALRPGDALNLTCV 582

  Fly   272 AIGSRPPAKITWWMGNLELHGHSQKVSE----------DGNVSTSVLSITPTREDHGKALSCRAT 326
            :|.|.||.       ||.|....:::.:          .|:.::..:.:..:..|||..::|||.
Mouse   583 SISSNPPV-------NLSLDKEGERLDDVAAKPQSAPFKGSAASRSVFLRVSSRDHGHRVTCRAH 640

  Fly   327 NELVRNGIRETAMKLNVFFIPTLQLDLGSNLNPEDIEEGDDVYFECKVHANPAAYKVVWK-HNHQ 390
            :|.:|..: .:..:|||.:.|..   ||..:....:.|.........|.||||.....|. ..::
Mouse   641 SEALRETV-SSFYRLNVLYPPEF---LGEQVRAVTVVEQGQALLPVSVSANPAPEAFNWTFRGYR 701

  Fly   391 IIQHNQRAGVIVSSGDLALQGVTRHQAGNYTCTASNVEGDGDSNVVELKVMYKPICR----PDQK 451
            :.........|:|.|.|.|..|||...|.|.....|.||..:: :::|.|.|.|..|    |.:.
Mouse   702 LSPAGGPRHRILSGGALQLWNVTRADDGFYQLHCQNSEGTAEA-LLKLDVHYAPTIRALKDPTEV 765

  Fly   452 KIYGVARNEAAEIVCEVDAFP-PPENFKW------------------SFNNTA----ETFDMPQS 493
            .:.|     :.:|||.|||.| .||.|.|                  |..:|.    ....:.|:
Mouse   766 NVGG-----SVDIVCTVDANPILPEMFSWERLGEDEEELNLDDMEKMSKGSTGRLRIRQAKLSQA 825

  Fly   494 G-----------------------FRPH---------------SAQGSTL--------------- 505
            |                       |.|.               |...:||               
Mouse   826 GAYQCIVDNGVAPAARGLVRLVVRFAPQVDHPTPLTKVAAAGDSTSSATLHCRARGVPNIDFTWT 890

  Fly   506 -----------TYTPVK------------------EMDFGTIMCWADNNVGQQKEPCVFHLIAAG 541
                       .||..|                  ..|:....|.|.|.:|  .:.....|::..
Mouse   891 KNGVPLDLQDPRYTEHKYHQGVVHSSLLTIANVSAAQDYALFKCTATNALG--SDHTNIQLVSIS 953

  Fly   542 KPEAPTNCTVVNQTSDSLEVYCIEGFDGGMRQWFLMEIFDQHS-GQLQANI-SAKFAALSVTGLD 604
            :|:.|....||:.:..|:.:....|||||:.|.|.:......| |.|..:: .|:....::|||.
Mouse   954 RPDPPLGLKVVSVSPHSVGLEWKPGFDGGLPQRFQIRYEALESPGFLYMDVLPAQATTFTLTGLK 1018

  Fly   605 AGRLFRIYVYAVNGRGRSDAIALDGYTLKAAEKQTVALTSYKGSAQSPDNFE------------L 657
            ....:||::.|.|..|.|      |.|.|..:   |::|: .|..|:|::.:            .
Mouse  1019 PSTRYRIWLLASNALGDS------GLTDKGIQ---VSITT-PGLDQAPEDTDQPLPTEQPPGPPR 1073

  Fly   658 TPILSIGIFVGILVAI---VCIGIGTIAALKLRSHKHQQQQKFVHPNAKFSRPGNLQIKDKISLP 719
            .|:|.:...||.|:.:   .|:| |.:...:||                           :::..
Mouse  1074 LPLLPVLFAVGGLLLLSNASCVG-GLLWRRRLR---------------------------RLAEE 1110

  Fly   720 LSHSEEMYDEKNPDVVPYNEVDGEYKQKSATQTPSGHLSTTSEVEISCKPGSTSGTGIVQANSAD 784
            :|...|...|:       :.:..||::...|.......||.|..|:.                  
Mouse  1111 ISEKTEAGSEE-------DRIRNEYEESQWTGDRDTRSSTVSTAEVD------------------ 1150

  Fly   785 SGTYQSSKDDELHYAELSLTNMPSGSSGASKKGQPMGGVGVVQHVVQQQQQQQQGQVQHPHQLLG 849
                                                                             
Mouse  1151 ----------------------------------------------------------------- 1150

  Fly   850 GTLPHGSSMRKLLPTIPATATLQRHKPNAGGMQ--------HPHQ-----HAPP----PTYD--- 894
               ||..|||...|.:|.|.....::....|::        |.:.     :.||    |.||   
Mouse  1151 ---PHYYSMRDFSPQLPPTLEEVSYRQAFTGIEDEDMAFPGHLYDEVERVYGPPGVWGPLYDEVQ 1212

  Fly   895 ---YDY------FEEPT-IYAQIDAYKTMQVDTG 918
               ||.      :|:|. ||.|:.|    .:|.|
Mouse  1213 MDPYDLRWPEVKYEDPRGIYDQVAA----DMDAG 1242

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
side-VINP_001036705.1 IG_like 35..140 CDD:214653 23/104 (22%)
Ig_3 157..230 CDD:290638 20/95 (21%)
IG_like 165..242 CDD:214653 18/99 (18%)
Ig 265..343 CDD:299845 18/87 (21%)
IG_like 267..343 CDD:214653 18/85 (21%)
IG_like 363..440 CDD:214653 21/77 (27%)
IGc2 364..429 CDD:197706 18/65 (28%)
IG_like 456..532 CDD:214653 28/180 (16%)
Ig_3 456..524 CDD:290638 26/172 (15%)
fn3 545..622 CDD:278470 23/78 (29%)
Nphs1NP_062332.2 Ig 52..128 CDD:299845
IG_like 52..127 CDD:214653
C2-set_2 155..242 CDD:285423
Ig 254..332 CDD:299845
IG_like 268..350 CDD:214653
C2-set_2 358..440 CDD:285423 21/93 (23%)
Ig 459..544 CDD:299845 19/94 (20%)
I-set 460..555 CDD:254352 21/107 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..516 3/24 (13%)
Ig 563..646 CDD:299845 18/89 (20%)
IG_like 670..750 CDD:214653 21/80 (26%)
Ig 676..750 CDD:299845 20/74 (27%)
Ig_3 753..834 CDD:290638 19/85 (22%)
IG_like 762..848 CDD:214653 17/90 (19%)
Ig 848..956 CDD:299845 14/109 (13%)
IG_like 859..949 CDD:214653 11/91 (12%)
fn3 956..1039 CDD:278470 25/88 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1048..1071 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1112..1143 6/37 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3515
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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