DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-VI and NPHS1

DIOPT Version :9

Sequence 1:	NP_001036705.1	Gene:	side-VI / 4379854	FlyBaseID:	FBgn0083950	Length:	1087	Species:	Drosophila melanogaster
Sequence 2:	NP_004637.1	Gene:	NPHS1 / 4868	HGNCID:	7908	Length:	1241	Species:	Homo sapiens

Alignment Length:	1000	Identity:	193/1000 - (19%)
Similarity:	328/1000 - (32%)	Gaps:	313/1000 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GPILICLIMGAITHANSHEHADGFK---PDGEILRVLVNSSAQ-------IKCDVGSSQADDKVL 59
            |..|.|....::: |.:.||....:   |...|  :::.|::|       :.|...||:  .:||
Human   312 GAQLSCEAHNSVS-AGTQEHGITLQVTFPPSAI--IILGSASQTENKNVTLSCVSKSSR--PRVL 371

  Fly    60 LVVW--YKNNLPIYSYDTRGAHAGTPSHWRDEEVLEDRAVFRTHKEPAELIINPVKEKDAGNFRC 122
            |..|  ::..||:......|.|.|                   |...:.|.....:|.:.....|
Human   372 LRWWLGWRQLLPMEETVMDGLHGG-------------------HISMSNLTFLARREDNGLTLTC 417

  Fly   123 RV--DFKLSQTRNSNVNLEVVVPPTQPIIFNERRLRIDSRAGPYE-----EGGSLEVTCVVYGGS 180
            ..  :....:|...::.|.|..|        .::|.|:   ||.|     .|..:.:.|:..||:
Human   418 EAFSEAFTKETFKKSLILNVKYP--------AQKLWIE---GPPEGQKLRAGTRVRLVCLAIGGN 471

  Fly   181 PPPTVIWLMN------------------GQLQNSVVDYTYDGAINSKLVVRNLSRIHQHAVYTCQ 227
            |.|:::|..:                  |.::.|       |:..|:.:|.........|.:||:
Human   472 PEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKS-------GSTFSRELVLVTGPSDNQAKFTCK 529

  Fly   228 ASNFHKKYVATNITIDLYLRPLLVEISFNNQPMSADRKYEIECQAIGSRPPAKITWWMGNLELHG 292
            |..     ::.:..:.:...|..|.|..|...:.......:.|.::.|.||..::|......|.|
Human   530 AGQ-----LSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEG 589

  Fly   293 HS---QKVSEDGNVSTSVLSITPTREDHGKALSCRATNELVRNGIRETAMKLNVFFIPTLQLDLG 354
            .:   ::....|:.:...:.:..:..|||:.::|||.:..:|..: .:..:|||.:.|..   ||
Human   590 VAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRETV-SSFYRLNVLYRPEF---LG 650

  Fly   355 SNLNPEDIEEGDDVYFECKVHANPAAYKVVWK-HNHQIIQHNQRAGVIVSSGDLALQGVTRHQAG 418
            ..:......|..:......|.||||.....|. ..:::.........|:|||.|.|..|||...|
Human   651 EQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWNVTRADDG 715

  Fly   419 NYTCTASNVEGDGDSNVVELKVMYKPICR----PDQKKIYGVARNEAAEIVCEVDAFP------- 472
            .|.....|.||..::. :.|.|.|.|..|    |.:..:.|     :.:|||.|||.|
Human   716 LYQLHCQNSEGTAEAR-LRLDVHYAPTIRALQDPTEVNVGG-----SVDIVCTVDANPILPGMFN 774

  Fly   473 -------------------------------------------------PPEN------------ 476
                                                             ||..
Human   775 WERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQ 839

  Fly   477 ---------------------------------FKWSFNNTAETFDMPQSGFRPHS-----AQGS 503
                                             |.|:.|..  ..|:....:..|:     ...|
Human   840 VEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGV--PLDLQDPRYTEHTYHQGGVHSS 902

  Fly   504 TLTYTPVK-EMDFGTIMCWADNNVGQQKEPCVFHLIAAGKPEAPTNCTVVNQTSDSLEVYCIEGF 567
            .||...|. ..|:....|.|.|.:|..:..  ..|::..:|:.|:...||:.|..|:.:....||
Human   903 LLTIANVSAAQDYALFTCTATNALGSDQTN--IQLVSISRPDPPSGLKVVSLTPHSVGLEWKPGF 965

  Fly   568 DGGMRQWFLM--EIFDQHSGQLQANISAKFAALSVTGLDAGRLFRIYVYAVNGRGRSDAIALDGY 630
            |||:.|.|.:  |............:..:....::|||.....:|:::.|.|..|.| .:|..|.
Human   966 DGGLPQRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDS-GLADKGT 1029

  Fly   631 TLKAAEKQTVALTSYKGSAQ---------SPDNFELTPIL-SIGIFVGILVA--IVCIGIGTIAA 683
            .|...   |..|....|..:         .|....|.|:| ::|   |:|:.  ..|:| |.:..
Human  1030 QLPIT---TPGLHQPSGEPEDQLPTEPPSGPSGLPLLPVLFALG---GLLLLSNASCVG-GVLWQ 1087

  Fly   684 LKLRSHKHQQQQKFVHPNAKFSRPGNLQIKDKISLPLSHSEEMYDEKNPDVVPYNEVDGEYKQKS 748
            .:||                           :::..:|...|...|:       :.|..||::..
Human  1088 RRLR---------------------------RLAEGISEKTEAGSEE-------DRVRNEYEESQ 1118

  Fly   749 AT---QTPSGHLSTT------------------SEVEISCKPGSTSGTGIVQANSADSGTYQSSK 792
            .|   .|.|..:|||                  ::.|:|...|.|                  .:
Human  1119 WTGERDTQSSTVSTTEAEPYYRSLRDFSPQLPPTQEEVSYSRGFT------------------GE 1165

  Fly   793 DDEL----H-YAELSLTNMPSGSSG 812
            |:::    | |.|:..|..|||:.|
Human  1166 DEDMAFPGHLYDEVERTYPPSGAWG 1190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VI	NP_001036705.1	IG_like	35..140	CDD:214653	20/115 (17%)
		Ig_3	157..230	CDD:290638	20/95 (21%)
		IG_like	165..242	CDD:214653	17/99 (17%)
		Ig	265..343	CDD:299845	16/80 (20%)
		IG_like	267..343	CDD:214653	16/78 (21%)
		IG_like	363..440	CDD:214653	22/77 (29%)
		IGc2	364..429	CDD:197706	19/65 (29%)
		IG_like	456..532	CDD:214653	23/182 (13%)
		Ig_3	456..524	CDD:290638	21/174 (12%)
		fn3	545..622	CDD:278470	20/78 (26%)
NPHS1	NP_004637.1	V-set	38..119	CDD:284989
		IG_like	38..113	CDD:214653
		C2-set_2	141..228	CDD:285423
		Ig	240..321	CDD:299845	3/8 (38%)
		IG_like	254..336	CDD:214653	6/24 (25%)
		Ig	345..424	CDD:299845	18/99 (18%)
		Ig	445..530	CDD:299845	19/94 (20%)
		I-set	446..541	CDD:254352	20/109 (18%)
		Ig	549..632	CDD:299845	16/82 (20%)
		IG_like	558..642	CDD:214653	16/84 (19%)
		I-set	646..736	CDD:254352	25/93 (27%)
		Ig	662..736	CDD:299845	21/74 (28%)
		Ig_3	739..820	CDD:290638	11/85 (13%)
		IG_like	748..821	CDD:214653	9/77 (12%)
		Ig8_hNephrin_like	834..942	CDD:143250	15/111 (14%)
		IG_like	845..935	CDD:214653	14/93 (15%)
		fn3	942..1023	CDD:278470	21/81 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1025..1057		6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1099..1137		11/44 (25%)
		Binds to NPHS2	1160..1241		10/48 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810