DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-VI and side

DIOPT Version :9

Sequence 1:	NP_001036705.1	Gene:	side-VI / 4379854	FlyBaseID:	FBgn0083950	Length:	1087	Species:	Drosophila melanogaster
Sequence 2:	NP_001247334.1	Gene:	side / 43300	FlyBaseID:	FBgn0016061	Length:	986	Species:	Drosophila melanogaster

Alignment Length:	905	Identity:	257/905 - (28%)
Similarity:	411/905 - (45%)	Gaps:	155/905 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSFTGPILICLIMGAITHANSHEHADGFKPD--GEILRVLVNSSAQIKCDVGSSQADDKVLLVVW 63
            :.||..:|.||  ..:...::.|.:..|:.:  ..::...:..:.::.||:....:.|.|.|::|
  Fly    66 VGFTLVLLTCL--QQLKSVSADEESQDFQKNIPARLVWAALGKTVELPCDLTPPTSQDSVKLLLW 128

  Fly    64 YKN--NLPIYSYDTRGAHAGTPSHWRDEEVLEDRAVFRTHKEP--AELIINPVKEKDAGNFRCRV 124
            :|:  .:|:||.|:||.:.....|......|..|..|.....|  :.|.||.||.:|.|.:||||
  Fly   129 FKDTTGIPLYSLDSRGGNVKLAPHAAIASDLGQRLFFSIGDNPKDSRLQINDVKPEDGGVYRCRV 193

  Fly   125 DFKLSQTRNSNVNLEVVVPPTQPIIFNERRLRIDSRAGPYEEGGSLEVTCVVYGGSPPPTVIWLM 189
            ||..|.|||...||.:||||.:|.||:.:...|...|||:.||..|.:.|.|.||.|||.|.|..
  Fly   194 DFFNSPTRNFRHNLTLVVPPEEPRIFDAQGKEISQMAGPFREGYELFLCCQVRGGRPPPKVTWWR 258

  Fly   190 N-----GQLQNSVVDYTYDGA--INSKLVVRNLSRIHQHAVYTCQASNFH-KKYVATNITIDLYL 246
            :     |....||    .:||  :.::|::...:|........|:|.... ...|..::|:.:||
  Fly   259 DDTELIGTSHTSV----EEGATVMVNQLLIGTTTRDFYGIRIECRAQGTRLVDPVRKDVTVQVYL 319

  Fly   247 RPLLVEISFNNQPMSADRKYEIECQAIGSRPPAKITWWMG-----NLELHGHSQKVSEDGNVSTS 306
            :|:.|:|:..|:.::|.:...|.|::.||.|.|||||.:.     |.|:..||.|  ||||::||
  Fly   320 KPVRVKIATPNELLTAGQPMPIRCESWGSYPAAKITWLLDGEPIRNAEVTVHSDK--EDGNITTS 382

  Fly   307 VLSITPTREDHGKALSCRATNELVRNGIRETAMKLNVFFIPTLQLDLGSNLNPEDI---EEGDDV 368
            :|::..|.|:....|:|||||.....|..|....:.|.:.||:.:.| :|.:|..:   .||.:|
  Fly   383 ILTLKVTSENDNAELTCRATNPWFSGGAIEDKRIIRVAYPPTVSVHL-ANEDPSRLVTRAEGQNV 446

  Fly   369 YFECKVHANPAAYKVVWKHNHQIIQHNQRAGVIVSSGDLALQGVT---RHQAGNYTCTASNVEGD 430
            .|:|:..|.|......|..|          |:.:|.....:..:|   |..||.|.|.|:|.||:
  Fly   447 TFKCRADARPPVTSYSWFKN----------GMRMSGESTEIMHLTQLERESAGAYACGATNTEGE 501

  Fly   431 GDSNVVELKVMYKPICR--PDQKKIYGVARNEAAEIVCEVDAFPPPE-NFKWSFNNTAETFDMPQ 492
            ..|:.:.|||.:.|.|:  .:|..| |.....:..:.|||||.||.. .|.|::|||.....:..
  Fly   502 TRSSSLTLKVQFSPRCKSGTEQTSI-GAVSLHSILVKCEVDADPPDSVRFSWTYNNTRNVSPVLN 565

  Fly   493 SGFRPHSAQGSTLTYTPVKEMDFGTIMCWADNNVGQQKEPCVFHLIAAGKPEAPTNCTVVNQTSD 557
            |..:.:.. .||:||.|..:.:..|:.|||.|.||:|..||:.|::.|..||||..|.:.|.|
  Fly   566 SRIQSNGL-ASTVTYLPQTDSELITLACWASNAVGRQTTPCLVHILPANTPEAPKACELRNDT-- 627

  Fly   558 SLEVYCIEGFDGGMRQWFLMEI---------------------FDQHSG---------------- 585
            .|||.|:.|.|||:.|:|::|:                     |.:..|
  Fly   628 VLEVVCVAGSDGGLSQYFMLEVVGGDPLYSGDPGGSAGQGRGQFSEAIGLGDNEISTLNDQATSA 692

  Fly   586 ---QLQANISAKFAALSVTGLDAGRLFRIYVYAVNGRGRSD-AIALDGYTLKA----------AE 636
               ::|.| |.:|   .:..|:.||.::..|||||.:|||: .:.::...:.|          :|
  Fly   693 PIFRMQEN-SPQF---RLNNLEPGREYQFLVYAVNAKGRSEPPVVIENVRVAAQLGPYDESILSE 753

  Fly   637 KQTVALTSYKG------------------SAQSPDNFELTPILSIGIFVG--ILVAIVCIGIGTI 681
            ..|.|.|::.|                  :...|:......||:..:.:|  ::.:|:..||..:
  Fly   754 DPTPAETTHHGGGGVGGSGSSSGLGTGASTGSGPEKQSTLLILAAVVVIGAVVVTSIIVAGIVVV 818

  Fly   682 AALKLRSHKHQQQQKFVHPNAKFSRPGNLQIKDKISLPLSHSEEMYDEKNPDVVPYNEVDGEYKQ 746
            ...:.|..:.|:.:|.:.|             .:..:|..:.||  ||.|    ...|..|....
  Fly   819 CRHRPRPPEPQEVRKSMRP-------------ARNDVPSMYIEE--DELN----ELEEGGGRAAD 864

  Fly   747 -KSATQTPSGHLSTTSEVEISCKPG--STSGTGIVQANSADSGTYQSSKDDELHYAELSL 803
             ::....|:.||.....:.:   ||  .:||..||..    :|.:....:..:.||:.||
  Fly   865 IRARVAPPNSHLCGGGGMPM---PGGVGSSGGAIVGV----AGPHHYISESFIQYAQPSL 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VI	NP_001036705.1	IG_like	35..140	CDD:214653	37/108 (34%)
		Ig_3	157..230	CDD:290638	25/79 (32%)
		IG_like	165..242	CDD:214653	22/84 (26%)
		Ig	265..343	CDD:299845	32/82 (39%)
		IG_like	267..343	CDD:214653	32/80 (40%)
		IG_like	363..440	CDD:214653	23/79 (29%)
		IGc2	364..429	CDD:197706	19/67 (28%)
		IG_like	456..532	CDD:214653	26/76 (34%)
		Ig_3	456..524	CDD:290638	22/68 (32%)
		fn3	545..622	CDD:278470	31/116 (27%)
side	NP_001247334.1	V-set	95..211	CDD:284989	37/115 (32%)
		IG_like	100..211	CDD:214653	37/110 (34%)
		Ig	235..301	CDD:299845	20/69 (29%)
		Ig	326..408	CDD:299845	33/83 (40%)
		IG_like	329..407	CDD:214653	32/79 (41%)
		IG_like	435..511	CDD:214653	23/85 (27%)
		Ig_2	442..511	CDD:290606	23/78 (29%)
		FN3	<700..735	CDD:238020	14/38 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470112
Domainoid	1	1.000	43	1.000	Domainoid score	I12361
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139790at33208
OrthoFinder	1	1.000	-	-		FOG0002810
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23278
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1676
	8	7.850