DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-VI and side-IV

DIOPT Version :9

Sequence 1:	NP_001036705.1	Gene:	side-VI / 4379854	FlyBaseID:	FBgn0083950	Length:	1087	Species:	Drosophila melanogaster
Sequence 2:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster

Alignment Length:	894	Identity:	307/894 - (34%)
Similarity:	465/894 - (52%)	Gaps:	143/894 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LVNSSAQIKCDVGSSQADDKVLLVVWYK--NNLPIYSYDTRGAHAGTPSHWRDEEVLEDRAVFRT 100
            ::...|.:.||:...:.||.|.:|:|::  :..|||::|.||...|....|........||.|.:
  Fly    84 VLGRQAMLPCDISPQERDDAVYMVLWFREGDGEPIYNFDVRGRQFGQARLWSSPTAFGTRAHFSS 148

  Fly   101 HKEPAELIINPVKEKDAGNFRCRVDFKLSQTRNSNVNLEVVVPPTQPIIFNERRLRIDSRAGPYE 165
            ...||:|.|:.::.:|.|.:||||||:.|.|||..:||.|:|||.:|:|:.:.|.........:.
  Fly   149 TTHPAQLKIDNIRIEDEGVYRCRVDFRNSPTRNLKINLTVIVPPDRPVIYGQNRHEKAGNVESFS 213

  Fly   166 EGGSLEVTCVVYGGSPPPTVIWLMNGQLQNSVVDYTY----DGAINSKLVVRNLSRIHQHAVYTC 226
            ||..:.::|.|.||.|.|.|.|    .|.|:.:|.::    ||...:.|...|:.|.|.::...|
  Fly   214 EGNDIVLSCEVSGGRPRPNVTW----YLDNTAIDESFEQRPDGKTINHLSYPNVGRQHLNSRLMC 274

  Fly   227 QASNFHKKYVATNIT--------IDLYLRPLLVEISFNNQPMSADRKYEIECQAIGSRPPAKITW 283
            .|||       ||:|        :|:.|:|:.|.|...::.:||||.|::||::.||:|||.|||
  Fly   275 VASN-------TNLTPPNNRVVILDVNLKPIAVHILTKDRFVSADRTYDVECKSSGSKPPALITW 332

  Fly   284 WMGNLELHGHSQKVSEDGNVSTSVLSITPTREDHGKALSCRATNELVRNGIRETAMKLNVFFIPT 348
            |.|:.:|...::..:|..|.|.|:|:.||.|||.||.|:|||.|:.:.....|...:|.|.:.||
  Fly   333 WKGSKQLKKLTKNFNEPDNQSLSILTFTPGREDDGKYLTCRAENQFIDGSAIEDKWRLIVHYQPT 397

  Fly   349 LQLDLGSNLNPEDIEEGDDVYFECKVHANPAAYKVVWKHNHQIIQHNQRAGVIVSSGDLALQGVT 413
            ..|.:||:|||:||:||||.||||.|.|||..||:.|.||.:.:|||..||||:|...|.||.|:
  Fly   398 TTLKIGSSLNPDDIKEGDDAYFECIVLANPKPYKMSWFHNGKELQHNISAGVILSDQSLVLQSVS 462

  Fly   414 RHQAGNYTCTASNVEGDGDSNVVELKVMYKPICRPDQKKIYGVARNEAAEIVCEVDAFPPPENFK 478
            |..||:|||.|.|.||.|.||.|.|::.|.|||..|.:::.|..::|...:.||||:.||.::|:
  Fly   463 RASAGDYTCLAVNSEGKGPSNPVTLRIRYAPICATDHEELLGALKHETLPLKCEVDSSPPADSFQ 527

  Fly   479 WSFNNTAETFDMPQSGFRPHSAQG--STLTYTPVKEMDFGTIMCWADNNVGQQKEPCVFHLIAAG 541
            |:||::.|..::|.   |.||::.  |.|.|||..::|:|||.|||.|::|.||.||||.::|||
  Fly   528 WTFNSSGEQTELPA---RLHSSETGMSRLNYTPSTDLDYGTISCWAKNSIGTQKSPCVFQIVAAG 589

  Fly   542 KPEAPTNCTVVNQTSDSLEVYCIEGFDGGMRQWFLMEIFDQHSGQLQANISAKFAALS--VTGLD 604
            :|....||:|.||:.|||:|.|:||||||:.|.|::|:.:.::.:|..||:.....::  :..||
  Fly   590 RPFPLQNCSVTNQSVDSLQVDCLEGFDGGLPQGFMLELVELNTLRLARNITVSHTPVTFVIDNLD 654

  Fly   605 AGRLFRIYVYAVNGRGRSDAIALDGYTLKAAEKQTVALTSYKGSAQSPDNFELTPILS-IGIFVG 668
            ....:|:.::|||.:|||:...:|....|...|.|.|.|..        :..|:|.|: :.:|.|
  Fly   655 QAATYRMVIFAVNAKGRSEPTIIDDINFKGVAKFTGASTGL--------SMPLSPFLAGLTLFCG 711

  Fly   669 ILVAIVCIGIGTI--------AALKLRSHKHQQ-------QQKFVHPNAKFSRPGNLQIKDKISL 718
            :|.||.||.:..|        :...|:..||.|       |...:||..:....||.|....: |
  Fly   712 LLFAIFCIMLAAIYRRISNRRSDSNLKVAKHTQLTIPADCQLDPLHPGVQTDGSGNHQPHHSL-L 775

  Fly   719 PLS---------------------------------------------------HS----EEMYD 728
            ||:                                                   ||    :...|
  Fly   776 PLNCDGRNAVDCGALGDVGGGGVGVGLDGGIKGSSPIGLVAMPGDTLRSNARNRHSPMADQADID 840

  Fly   729 EKNPDVVPYNEVDGEYKQK--SATQTPSGHLSTTS---------EVEISCKPGSTSGTGIVQANS 782
            :.:|||:|     .:|:::  .:..:|.|..|.::         |.|:: |.||..|.|..:..|
  Fly   841 DTDPDVIP-----NQYEKRPLKSLVSPPGFASPSNRLMQRDYLRETELT-KGGSDVGMGAAEGLS 899

  Fly   783 ADSGTYQSSKDDELHYAELSLTNMPS---GSSGASKKG-----QPMGGV 823
            : .|...||.::.|||     |..||   ..:..:|||     .|:|.:
  Fly   900 S-IGLMSSSGNEVLHY-----TFRPSKQISYATLNKKGITTCSPPLGSL 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VI	NP_001036705.1	IG_like	35..140	CDD:214653	37/103 (36%)
		Ig_3	157..230	CDD:290638	21/76 (28%)
		IG_like	165..242	CDD:214653	26/88 (30%)
		Ig	265..343	CDD:299845	33/77 (43%)
		IG_like	267..343	CDD:214653	32/75 (43%)
		IG_like	363..440	CDD:214653	44/76 (58%)
		IGc2	364..429	CDD:197706	37/64 (58%)
		IG_like	456..532	CDD:214653	32/77 (42%)
		Ig_3	456..524	CDD:290638	28/69 (41%)
		fn3	545..622	CDD:278470	29/78 (37%)
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	37/103 (36%)
		IG_like	80..188	CDD:214653	37/103 (36%)
		Ig	210..281	CDD:299845	24/81 (30%)
		Ig	319..392	CDD:299845	31/72 (43%)
		IG_like	319..383	CDD:214653	29/63 (46%)
		IG_like	412..489	CDD:214653	44/76 (58%)
		IGc2	413..478	CDD:197706	37/64 (58%)
		Ig_3	509..572	CDD:290638	28/65 (43%)
		fn3	593..675	CDD:278470	31/81 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470107
Domainoid	1	1.000	41	1.000	Domainoid score	I12487
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139790at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23278
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1676
	7	6.850